RNA profiling of circulating tumor cells systemically captured from diagnostic leukapheresis products in prostate cancer patients

Article Oncology

Leukapheresis increases circulating tumour cell yield in non-small cell lung cancer, counts related to tumour response and survival

Menno Tamminga et al.

Summary: DLA detected nine times more CTCs than in the peripheral blood, and the sustained presence of CTCs in DLA after treatment was associated with therapy failure and shortened PFS.

BRITISH JOURNAL OF CANCER (2022)

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Article Oncology

Cancer statistics, 2022

Rebecca L. Siegel et al.

Summary: Each year, the American Cancer Society compiles data on cancer occurrence and outcomes in the United States. The latest data shows that breast and prostate cancer progress has stagnated, while lung cancer has shown improvements in survival rates. Lung cancer incidence for advanced disease has declined while localized-stage rates have increased, resulting in higher survival rates. Mortality patterns align with incidence trends, with lung cancer deaths declining rapidly, breast cancer deaths slowing, and prostate cancer deaths stabilizing.

CA-A CANCER JOURNAL FOR CLINICIANS (2022)

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Article Medicine, General & Internal

Strategies for Isolating and Propagating Circulating Tumor Cells in Men with Metastatic Prostate Cancer

Gerit Theil et al.

Summary: This study discusses isolation and characterization methods for circulating tumor cells (CTCs) in prostate cancer patients, finding that a PCa-functionalized CellCollector system can improve the sensitivity and specificity of CTC detection. The combination of two isolation techniques with different capturing methods also significantly impacts patient survival outcomes.

DIAGNOSTICS (2022)

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Review Pharmacology & Pharmacy

Circulating tumor cells in precision medicine: challenges and opportunities

Brittany Rupp et al.

Summary: The mutational and phenotypic landscape of tumors is dynamic, and constant monitoring of cancer patients using liquid biopsy can provide important tumor information for diagnosis, prognosis, and treatment.

TRENDS IN PHARMACOLOGICAL SCIENCES (2022)

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Review Multidisciplinary Sciences

Circulating tumor cells: Towards mechanical phenotyping of metastasis

Marina Peralta et al.

Summary: Metastatic dissemination, which occurs when circulating tumor cells spread through body fluids, is responsible for the majority of cancer-related deaths. This review discusses the importance of the mechanical properties of circulating tumor cells in determining their metastatic success and identifies potential therapeutic targets.

ISCIENCE (2022)

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Review Medicine, General & Internal

Leukapheresis and Hyperleukocytosis, Past and Future

Dongdong Zhang et al.

Summary: Hyperleukocytosis is a hematologic crisis characterized by excessive proliferation of leukemic cells, requiring prompt intervention. Leukapheresis can rapidly remove excessive leukocytes, correct metabolic abnormalities, alleviate leukostasis symptoms, and is generally well tolerated. Leukapheresis has become an imperative adjuvant therapy for hyperleukocytosis, especially for patients who cannot undergo cytoreduction with Ara-C or hydroxyurea.

INTERNATIONAL JOURNAL OF GENERAL MEDICINE (2021)

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Article Chemistry, Analytical

High-Throughput Simultaneous mRNA Profiling Using nCounter Technology Demonstrates That Extracellular Vesicles Contain Different mRNA Transcripts Than Their Parental Prostate Cancer Cells

Liang Dong et al.

Summary: Extracellular vesicles (EVs) are important players in intercellular communication, with mRNA transcripts in EVs potentially contributing to cancer progression. The cargo of EVs is not completely reflective of their cell origin, indicating a complex mechanism of cargo sorting that requires further elucidation.

ANALYTICAL CHEMISTRY (2021)

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Review Biochemical Research Methods

The role of liquid biopsies in prostate cancer management

Chi-Ju Kim et al.

Summary: Liquid biopsy serves as a valuable tool in cancer diagnosis and treatment guidance, utilizing biomarkers such as CTCs, EVs, and ctDNA. Prostate cancer ranks as the second most common cancer in males globally, with management strategies focusing on biopsy and prevention of metastatic disease.

LAB ON A CHIP (2021)

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Article Oncology