Multiple System Atrophy: Advances in Diagnosis and Therapy

This review summarizes improvements in understanding the pathophysiology and early clinical symptoms of multiple system atrophy (MSA) and advancements in diagnostic methods and disease-modifying therapies for the condition. In 2022, the Movement Disorder Society proposed new diagnostic criteria to develop disease-modifying therapies and promote clinical trials of MSA since the second consensus was proposed in 2008. Regarding pathogenesis, cutting-edge findings have accumulated on the interactions of alpha-synuclein, neuroinflammation, and oligodendroglia with neurons. In neuroimaging, introducing artificial intelligence, machine learning, and deep learning has notably improved diagnostic accuracy and individual analyses. Advancements in treatment have also been achieved, including immunotherapy therapy against alpha-synuclein and serotonin-targeted and mesenchymal stem cell therapies, which are thought to affect several aspects of the disease, including neuroinflammation. The accelerated progress in clarifying the pathogenesis of MSA over the past few years and the development of diagnostic techniques for detecting early-stage MSA are expected to facilitate the development of disease-modifying therapies for one of the most intractable neurodegenerative diseases.

Automated summary

This review summarizes the improvements in understanding the pathophysiology and early clinical symptoms of multiple system atrophy (MSA), as well as advancements in diagnostic methods and disease-modifying therapies for the condition. The introduction of new diagnostic criteria in 2022 and the use of artificial intelligence and machine learning in neuroimaging have significantly improved diagnostic accuracy. Treatment advancements, including immunotherapy against alpha-synuclein and stem cell therapies, show promise in targeting different aspects of the disease.