Journal
ADVANCED COMPOSITES AND HYBRID MATERIALS
Volume 6, Issue 1, Pages -Publisher
SPRINGERNATURE
DOI: 10.1007/s42114-022-00576-2
Keywords
Sports osteoarthritis; Silica aerogel; Resveratrol; Anti-inflammatory effect; Nanocarrier
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In this study, a silica aerogel was prepared to carry resveratrol as a nanodrug complex system, which showed high drug-loading rate and sustained release effect. The complex system demonstrated good biocompatibility and enhanced anti-inflammatory actions in human chondrocytes in vitro. In a rat model of exercise-induced osteoarthritis, the complex system reduced inflammatory factors and increased the expression of type II collagen. Resveratrol was found to activate SIRT-1 and alleviate cartilage degradation through inhibiting the NF-kappa B-mediated inflammatory pathway. These findings suggest that the complex system could provide a novel noninvasive approach for targeted osteoarthritis therapy with potential for oral drug delivery.
Sports osteoarthritis (OA) is the most prevalent chronic joint disease in professional and recreational athletes. Resveratrol (RES), which is extracted from plants, has excellent anti-inflammatory properties. However, its application in OA treatment is limited by its poor water solubility, low bioavailability, and rapid metabolism. In this study, a silica aerogel (SA) was prepared through the sol-gel method and used to carry RES in the form of a nanodrug complex system (RSA) with a high drug-loading rate of 21.8% and a sustained release effect that lasted more than 6 hours. RSA had good biocompatibility in human chondrocytes when the concentration was less than 40 mu g/mL and enhanced the anti-inflammatory actions of RES in vitro. A rat model of exercise-induced osteoarthritis was constructed to examine the therapeutic effects of RSA in vivo. Furthermore, the inflammatory factors involved in cartilage degradation and catabolism were reduced to 14.6-19.1% those of the original values after RES intervention, while the expression of type II collagen significantly increased. Moreover, RES was found to activate SIRT-1 by inhibiting the NF-kappa B-mediated inflammatory pathway, which also alleviated the degradation of cartilage matrix. These results indicated that the use of RSA could provide a novel noninvasive approach for targeted OA therapy with the potential for oral drug delivery.
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