Journal
ANNALS OF GASTROENTEROLOGICAL SURGERY
Volume 7, Issue 3, Pages 503-511Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ags3.12637
Keywords
CALLY index; distal cholangiocarcinoma; pancreaticoduodenectomy
Categories
Ask authors/readers for more resources
The aim of this study was to investigate the prognostic value of the CALLY index (C-reactive protein-albumin-lymphocyte index) in patients with distal cholangiocarcinoma after pancreaticoduodenectomy. The results showed that the CALLY index was associated with disease-free survival and overall survival, suggesting its importance as an indicator for long-term outcomes in these patients.
AimThe C-reactive protein (CRP)-albumin-lymphocyte (CALLY) index is a novel inflammation-based biomarker, which has been associated with long-term outcomes in patients with hepatocellular carcinoma. We aimed to investigate whether the CALLY index can predict the prognosis for distal cholangiocarcinoma after pancreaticoduodenectomy. MethodsThe study comprised 143 patients who had undergone primary pancreaticoduodenectomy for distal cholangiocarcinoma between 2002 to 2019. The CALLY index was defined as (albumin x lymphocyte)/ (CRP x 10(4)). We investigated the association of CALLY index with disease-free survival and overall survival by univariate and multivariate analyses. ResultsEighty-seven (61%) patients had a preoperative CALLY index <3.5. In multivariate analysis, obstructive jaundice drainage (P < .01), poorly differentiated tumor (P < .01), and CALLY index<3.5 (P = .02) were independent predictors of disease-free survival, while obstructive jaundice drainage (P < .01), poorly differentiated tumor (P < .01), and CALLY index <3.5 (P = .02) were independent predictors of overall survival. ConclusionThe CALLY index may be an independent and significant indicator of poor long-term outcomes in patients with distal cholangiocarcinoma after pancreaticoduodenectomy, suggesting the importance of comprehensive assessment for inflammatory status.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available