Journal
ACS APPLIED NANO MATERIALS
Volume 6, Issue 3, Pages 2141-2150Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsanm.2c05210
Keywords
biofilm; magnetic drive; photodynamic therapy; chemotherapy; Pseudomonas aeruginosa; self-immolation
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A combined therapy using bactericidal nano-micelles Ce6-ZnFeO4@ABCsi-micelles was developed to address biofilm infections. The nano-micelles could penetrate the external barrier of the biofilm and disrupt its barrier through the generation of reactive oxygen species (ROS) by the photosensitizer Ce6, facilitating the distribution of antibiotics and achieving a high clearance rate of bacteria. In a murine abscess model, the targeted driving effect of an external magnetic field, along with the chemotherapeutic and photodynamic effects, enabled the clearance of wound infection.
During the infections of wounds or medical device surfaces, bacteria such as Pseudomonas aeruginosa are prone to forming biofilms which prevent the penetration of antimicrobial agents. Herein, a combined therapy using bactericidal nano-micelles Ce6-ZnFeO4@ABCsi-micelles was developed that employed colistin cross-linked Pluronic micelles as a carrier, with the magnetic metal oxide ZnFeO4 and photosensitizer dihydroporphyrin (Ce6) encapsulated in the core of micelles. Driven by an external magnetic field, the nano-micelles could penetrate the external barrier of the biofilm. Reactive oxygen species (ROS) generated by the photosensitizer Ce6 disrupted the barrier of the biofilm, which facilitated the distribution of the Ce6 and colistin antibiotics into the biofilm, realizing a 99.5% clearance rate of bacteria. Using such a combination of chemotherapy and photodynamic therapy, Ce6-ZnFeO4@ABCsi-micelles could clear wound infection in a murine abscess model, owing to the targeted driving effect of the external magnetic field, along with the chemotherapeutic effect of colistin and the photodynamic effect of Ce6. This design provides an effective targeted therapeutic strategy to address biofilm infections.
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