Effect of the Use of Gnrh Analogs in Low-Grade Cerebral Glioma

Low-grade gliomas are the most common brain tumors in children. This tumor type presents a wide range of clinical, histological, and biological behaviors. In recent years, an association between estrogens and progesterone and the development of tumors has been suggested. A case of a 2-year-old girl is described with a low-grade brain tumor treated with chemotherapy and disease stabilization. The treatment with Decapeptyl (R) was initiated due to precocious puberty, and the tumor showed a decrease in its solid component-more than 50% of the initial size-three years after starting treatment. Several studies have described the influence of estrogen and progesterone on the development of gliomas, decreasing or increasing their expression in those tumors with greater aggressiveness, respectively. Despite the fact that the tumor-hormonal expression relationship in other tumor types has been evaluated, its role in the treatment of brain tumors remains unknown.

Automated summary

Low-grade gliomas are common brain tumors in children, with diverse clinical, histological, and biological behaviors. Recent research has suggested a link between estrogens and progesterone and tumor development. This case study describes a 2-year-old girl with a low-grade brain tumor who showed tumor reduction after starting treatment with Decapeptyl (R) for precocious puberty. While the influence of hormones on glioma development has been studied, their role in brain tumor treatment remains unclear.