4.5 Article

Skin Barrier Function and Infant Tidal Flow-Volume Loops-A Population-Based Observational Study

Journal

CHILDREN-BASEL
Volume 10, Issue 1, Pages -

Publisher

MDPI
DOI: 10.3390/children10010088

Keywords

eczema; filaggrin; infant; PreventADALL; respiratory function tests; transepidermal water loss

Categories

Ask authors/readers for more resources

This study aimed to investigate the association between high transepidermal water loss (TEWL), eczema, Filaggrin (FLG) mutations and lung function in three-month-old infants. The results showed that high TEWL was associated with lower lung function, while eczema or FLG mutations were not.
Background: The relationship between the skin barrier- and lung function in infancy is largely unexplored. We aimed to explore if reduced skin barrier function by high transepidermal water loss (TEWL), or manifestations of eczema or Filaggrin (FLG) mutations, were associated with lower lung function in three-month-old infants. Methods: From the population-based PreventADALL cohort, 899 infants with lung function measurements and information on either TEWL, eczema at three months of age and/or FLG mutations were included. Lower lung function by tidal flow-volume loops was defined as a ratio of time to peak tidal expiratory flow to expiratory time (t(PTEF)/t(E)) t(PTEF) <0.17 s (<25th percentile). A high TEWL >8.83 g/m(2)/h (>75th percentile) denoted reduced skin barrier function, and DNA was genotyped for FLG mutations (R501X, 2282del4 and R2447X). Results: Neither a high TEWL, nor eczema or FLG mutations, were associated with a lower t(PTEF)/t(E). While a high TEWL was associated with a lower t(PTEF); adjusted OR (95% CI) 1.61 (1.08, 2.42), the presence of eczema or FLG mutations were not. Conclusions: Overall, a high TEWL, eczema or FLG mutations were not associated with lower lung function in healthy three-month-old infants. However, an inverse association between high TEWL and t(PTEF) was observed, indicating a possible link between the skin barrier- and lung function in early infancy.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.5
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available