Journal
BJPSYCH OPEN
Volume 8, Issue 6, Pages -Publisher
CAMBRIDGE UNIV PRESS
DOI: 10.1192/bjo.2022.590
Keywords
Psychotic disorders; antipsychotics; metabolic syndrome; obesity; schizophrenia
Categories
Funding
- Morris Family Philanthropic Foundation
- University of Melbourne
- National Health and Medical Research Council (NHMRC) in Australia [1142045]
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Background factors such as obesity, smoking, and sedentary behavior contribute to early mortality in psychotic disorders. However, adding a physical health nurse to the care of young people with first-episode psychosis did not prevent clinically significant weight gain, smoking, metabolic syndrome, or sedentary behavior. This suggests that more intensive interventions are needed.
Background Factors that contribute to the early mortality observed in psychotic disorders, specifically obesity, smoking and sedentary behaviour, occur early in the disorder. Aims We aimed to determine whether the integration of a physical health nurse in the care of young people with first-episode psychosis could prevent clinically significant weight gain (>= 7% body weight). Secondary outcomes included rates of smoking, metabolic syndrome and sedentary behaviour. Method In this single-blind, randomised controlled trial, participants who had received under 4 weeks of antipsychotic medication were randomly allocated to either the intervention (addition of a physical health nurse to their care) or treatment as usual (TAU) for 12 weeks. Results Of the 77 participants, there were follow-up data for 86.8% (n = 33) of the intervention group and 82.1% (n = 32) of the TAU group. After 12 weeks, 27.3% of the intervention group experienced clinically significant weight gain compared with 34.4% of the TAU group (odds ratio 0.72, 95% CI 0.25-2.06, P = 0.54). After 6 months, 40.7% of the intervention group gained clinically significant weight compared with 44.1% of the TAU group (P = 0.79). There was no difference in mean change in weight between groups after 12 weeks (2.6 kg v. 2.9 kg, P = 0.87) or 6 months (3.6 kg v. 4.3 kg, P = 0.64). There were no differences in the rates of tobacco smoking cessation, prevalence of metabolic syndrome or physical activity levels. Conclusions This intervention failed to prevent the metabolic complications that are highly prevalent in psychotic disorders in the short to medium term, indicating that more intensive interventions are required.
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