Journal
JOURNAL OF SEPARATION SCIENCE
Volume 40, Issue 1, Pages 336-345Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jssc.201600927
Keywords
High-speed counter-current chromatography; Liquid-liquid extraction; Spiral counter-current chromatography; Stationary phases
Categories
Funding
- National Natural Sciences Foundation of China (NSFC) [21505144]
- Natural Science Foundation of Gansu Province [1506RJZA283]
- Science and Technology Service Network Initiative [KFJ-SW-STS-146]
- Youth Innovation Promotion Association CAS [2016369]
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Depending on the rapid growth in the radial gradient of the centrifugal force, spiral countercurrent chromatography can greatly improve the retention of stationary phase, especially for the aqueous two-phase systems with ultra-polar and high viscosity that are not well retained in the conventional multilayer coils counter-current chromatography. As a result, it is an attractive and alternative technology that is suited for separation of hydrophilic compounds and has led to many exciting progress in recent years. This review presents the recent advances and applications of spiral counter-current chromatography, including its major benefits and limitations, some novel methods to improve the separation efficiency and its applications in separation of real samples. In addition, the remaining challenges and future perspectives on development of spiral counter-current chromatography also are proposed in this article.
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