Helicobacter pylori-Positive Gastric Biopsies-Association with Clinical Predictors

Article Cardiac & Cardiovascular Systems

CagA+ Helicobacter pylori, Not CagA- Helicobacter pylori, Infection Impairs Endothelial Function Through Exosomes-Mediated ROS Formation

Xiujuan Xia et al.

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FRONTIERS IN CARDIOVASCULAR MEDICINE (2022)

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Article Gastroenterology & Hepatology

British Society of Gastroenterology guidelines on the management of functional dyspepsia

Christopher J. Black et al.

Summary: This research aims to review and summarize the current evidence on functional dyspepsia, provide a practical framework for evidence-based diagnosis and treatment of patients, and provide specific recommendations based on the GRADE system. The study also considers the development of novel treatment methods and highlights areas of unmet need and priorities for future research.

GUT (2022)

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Article Gastroenterology & Hepatology

Management of Helicobacter pylori infection: the Maastricht VI/Florence consensus report

Peter Malfertheiner et al.

Summary: Helicobacter pylori infection is recognized as an infectious disease and requires optimized management to prevent complications and gastric cancer. Continuous updates in treatment strategies and testing methods are necessary due to rising antibiotic resistance and the impact on gut microbiota.

GUT (2022)

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Review Oncology

Mapping the genomic diaspora of gastric cancer

Khay Guan Yeoh et al.

Summary: This review discusses the advances in understanding the genomic landscape of gastric cancer, including driver gene alterations, molecular subtypes, transcriptomic changes, and their interactions with environmental influences and tumor microenvironment. Genomic findings will facilitate precision oncology and prevention strategies for gastric cancer.

NATURE REVIEWS CANCER (2022)

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Article Biochemistry & Molecular Biology

Alcohol consumption and risk of stomach cancer: A meta-analysis

Wenting Deng et al.

Summary: The study revealed a significant association between alcohol consumption and increased risk of stomach cancer. Heterogeneity in results across different regions and subsites of stomach cancer indicates potential factors such as smoking rates, Helicobacter pylori infection, obesity, and genetic susceptibility. The dose-response analysis showed that higher daily alcohol intake is correlated with a higher risk of stomach cancer.

CHEMICO-BIOLOGICAL INTERACTIONS (2021)

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Article Oncology

Characteristics of gastric precancerous conditions and Helicobacter pylori infection among dyspeptic patients in north-eastern Iran: is endoscopic biopsy and histopathological assessment necessary?

Abbas Esmaeilzadeh et al.

Summary: Early detection and appropriate treatment of precancerous, mucosal changes can reduce the prevalence of life-threatening gastric cancer. This study found a high prevalence of H. pylori infection and precancerous conditions in dyspeptic patients, especially those over 40 years old with opium addiction, suggesting the need for gastric endoscopy and biopsy even in patients with normal-appearing mucosa.

BMC CANCER (2021)

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Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Review Medicine, General & Internal

The Effect of Helicobacter pylori Eradication on Lipid Levels: A Meta-Analysis

Jun Watanabe et al.

Summary: Eradication of Helicobacter pylori increases HDL-C levels and triglyceride levels, but does not significantly affect low-density lipoprotein-cholesterol levels. Further studies are needed to clarify the effects of lipid changes following H. pylori eradication on cardiovascular diseases.

JOURNAL OF CLINICAL MEDICINE (2021)

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Article Gastroenterology & Hepatology

Helicobacter pylori resistance to antibiotics in Europe in 2018 and its relationship to antibiotic consumption in the community

Francis Megraud et al.

Summary: The study confirmed a positive correlation between macrolide and quinolone consumption in the community and corresponding H. pylori resistance in European countries. Therefore, treatment of H. pylori with clarithromycin and levofloxacin should involve susceptibility testing in most European countries before starting the treatment.

GUT (2021)

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Review Medicine, General & Internal

Current Helicobacter pylori Diagnostics

Dmitry S. Bordin et al.

Summary: This article reviews the various methods available for detecting Helicobacter pylori, including both invasive and non-invasive diagnostic tests, highlights the advancements and new developments in endoscopic examination techniques, and discusses the advantages and limitations of different diagnostic methods and their applications.

DIAGNOSTICS (2021)

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Review Gastroenterology & Hepatology

40 Years of Helicobacter pylori: A Revolution in Biomedical Thought

Ioannis Alexandros Charitos et al.

Summary: Scientific research has revealed the role of Helicobacter pylori in conditions such as peptic ulcers, carcinogenesis, and gastric lymphoma over the years, and even its potential implications in other diseases like cardiovascular ones. Advances in understanding H. pylori's pathogenic mechanisms have led to improved detection and evolving therapies for associated cancers, making it a more treatable disease with ongoing research on resistance and pharma compliance. Probiotic therapy is also considered a valuable adjuvant in this field.

GASTROENTEROLOGY INSIGHTS (2021)

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Prevalence, risk factors, and surveillance patterns for gastric intestinal metaplasia among patients undergoing upper endoscopy with biopsy

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GASTROINTESTINAL ENDOSCOPY (2020)

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Previous Helicobacter pylori infection-induced atrophic gastritis: A distinct disease entity in an understudied population without a history of eradication

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Mechanisms of the Epithelial-Mesenchymal Transition and Tumor Microenvironment in Helicobacter pylori-Induced Gastric Cancer

Jacek Baj et al.

CELLS (2020)

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AGA Clinical Practice Guidelines on the Gastrointestinal Evaluation of Iron Deficiency Anemia

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2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease

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JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2019)

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Exosomes in gastric cancer: roles, mechanisms, and applications

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MOLECULAR CANCER (2019)

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Helicobacter pylori Infection

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NEW ENGLAND JOURNAL OF MEDICINE (2019)

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Smoking, Helicobacter Pylori Serology, and Gastric Cancer Risk in Prospective Studies from China, Japan, and Korea

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CANCER PREVENTION RESEARCH (2019)

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Helicobacter pylori and cytokine gene variants as predictors of premalignant gastric lesions

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WORLD JOURNAL OF GASTROENTEROLOGY (2019)

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Review of current diagnostic methods and advances in Helicobacter pylori diagnostics in the era of next generation sequencing

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WORLD JOURNAL OF GASTROENTEROLOGY (2019)

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Biopsy strategies for endoscopic screening of pre-malignant gastric lesions

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BLOOD (2019)

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Helicobacter pylori and low-dose aspirin ulcer risk: A meta-analysis

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JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2019)

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The epidemiology of Helicobacter pylori infection in Europe and the impact of lifestyle on its natural evolution toward stomach cancer after infection: A systematic review

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An updated systematic review and meta-analysis on the association between Helicobacter pylori infection and iron deficiency anemia

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Review article: the prevalence of Helicobacter pylori and the incidence of gastric cancer across Europe

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Alcohol intake and Helicobacter pylori infection: a dose-response meta-analysis of observational studies

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POLISH JOURNAL OF PATHOLOGY (2015)

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The Prevalence of Gastric Intestinal Metaplasia and Distribution of Helicobacter pylori Infection, Atrophy, Dysplasia, and Cancer in Its Subtypes

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Diagnosis of Helicobacter pylori: What should be the gold standard?

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Helicobacter pylori-Positive Gastric Biopsies-Association with Clinical Predictors

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