Journal
JOURNAL OF SEPARATION SCIENCE
Volume 39, Issue 17, Pages 3457-3468Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jssc.201600083
Keywords
Major constituents; Qualitative analysis; Traditional Chinese medicine; Ultra-high performance liquid chromatography; Xue Fu Zhu Yu Decoction
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Funding
- National Natural Science Foundation of China [21175157, 21375151, 81303074]
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Xue Fu Zhu Yu Decoction, a famous formula that has been used for treating many blood stasis-caused diseases for many centuries, comprises 11 kinds of traditional Chinese medicines. A convenient, efficient, and rapid analytical method was developed to simultaneously determine the major compounds in this decoction. An ultra-high performance liquid chromatography with hybrid ion trap time-of-flight mass spectrometry method was used to rapidly separate and detect the major constituents of the decoction. Using this technique, we identified or tentatively identified 34 compounds, including 21 flavonoids, 5 terpenoids, 3 organic acids, 2 lactones, 1 alkaloid, 1 amino acid, and 1 cyanogenic glycoside. The MS analysis of these constituents was described in detail. Findings may contribute to future metabolic and pharmacokinetic studies of this medicine.
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