Journal
CHEMOSENSORS
Volume 10, Issue 11, Pages -Publisher
MDPI
DOI: 10.3390/chemosensors10110468
Keywords
deferoxamine; DFO; iron(III); iron(III) chelators; deferoxamine-based polymers; deferoxamine-based sensors; deferoxamine-modified electrodes; deferoxamine-functionalized nanoparticles; drug delivery; analytical chemistry; metal-ions sensing
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Deferoxamine is a versatile siderophore that can strongly bind iron(III), making it suitable for various clinical and analytical applications, especially in the field of iron(III) chelation and recognition.
Deferoxamine (DFO) is a siderophore widely studied for its ability to bind iron(III) strongly. Thanks to its versatility, it is suitable for several clinical and analytical applications, from the recognized iron(III) chelation therapy to the most recent applications in sensing. The presence of three hydroxamic functional groups enables Deferoxamine to form stable complexes with iron(III) and other divalent and trivalent metal ions. Moreover, the terminal amino group in the DFO molecule, not involved in metal ion complexation, allows modification or functionalization of solid phases, nanoobjects, biopolymers, electrodes and optical devices. This review summarizes and discusses deferoxamine-based applications for the chelation and recognition of Fe(III).
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