Journal
JOURNAL OF SEPARATION SCIENCE
Volume 39, Issue 6, Pages 1110-1117Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jssc.201501157
Keywords
Capillary liquid chromatography; Cyclodextrins; Enantioseparation
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Funding
- China State Key Basic Research Program Grant [2013CB-911203, 2012CB910601]
- National Natural Sciences Foundation of China [21235006, 21175133]
- Creative Research Group Project of NSFC [21321064]
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Cyclodextrins and their derivatives are one of the most common and successful chiral selectors. However, there have been few publications about the use of cyclodextrin-modified monoliths. In this study, organic hybrid monoliths were prepared by the immobilization of derivatized -cyclodextrin alone or with l-2-allylglycine hydrochloride to the polyhedral oligomeric silsesquioxane methacryl substituted monolith. The main topic of this study is a combined system with dual chiral selectors (l-2-allylglycine hydrochloride and -cyclodextrin) as monolithic chiral stationary phase. The effect of l-2-allylglycine hydrochloride concentration on enantioseparation was investigated. The enantioseparation of the four acidic compounds with resolutions up to 2.87 was achieved within 2.5 min on the prepared chiral monolithic column in capillary liquid chromatography. Moreover, the possible mechanism of enantioseparation was discussed.
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