Recent Advances in the Roles of MicroRNA and MicroRNA-Based Diagnosis in Neurodegenerative Diseases

Article Biochemistry & Molecular Biology

Downregulation of serum miR-106b: a potential biomarker for Alzheimer disease

Soheil Madadi et al.

Summary: miR-106b may be a promising serum biomarker for early diagnosis of Alzheimer's disease.

ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY (2022)

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Article Chemistry, Multidisciplinary

Development and evaluation of a thermostatic nucleic acid testing device based on magnesium pyrophosphate precipitation for detecting Enterocytozoon hepatopenaei

Zhu Chen et al.

Summary: The newly developed device shows high sensitivity and good specificity for Enterocytozoon hepatopenaei infection, enhancing stability, uniformity, and shortening testing time, with efficient light absorbance capability.

CHINESE CHEMICAL LETTERS (2022)

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Article Chemistry, Multidisciplinary

Highly sensitive smartphone-based detection of Listeria monocytogenes using SYTO9

Sha Liu et al.

Summary: Listeriosis, caused by Listeria monocytogenes (LM), is a major global foodborne disease with a high mortality rate of 20% to 30%. Current LM detection methods are time-consuming and have low sensitivity. This study developed a rapid detection method using SYTO9 staining and image processing, based on loop-mediated isothermal amplification (LAMP). The method was simple, sensitive, and rapid, providing a new approach for the rapid detection of LM and other foodborne bacterial pathogens.

CHINESE CHEMICAL LETTERS (2022)

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Article Neurosciences

MicroRNA-22: a Novel and Potent Biological Therapeutics in Neurological Disorders

Seyed Hamidreza Rastegar-Moghaddam et al.

Summary: This article discusses the protective and therapeutic effects of miR-22 on neurological diseases and injuries, as well as its correlation with other diseases. The research provides a new therapeutic perspective for the application of miR-22 in treating neurological disorders.

MOLECULAR NEUROBIOLOGY (2022)

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Review Neurosciences

MicroRNAs in the pathophysiology of Alzheimer's disease and Parkinson's disease: an overview

Mohammad Rafi Khezri et al.

Summary: Neurodegenerative diseases, a major cause of mortality and functional dependence among the elderly, have a low success rate in clinical pipelines. MicroRNAs play a crucial role in regulating the occurrence of neurodegenerative diseases, and alterations in certain microRNA levels in clinical samples may have significant clinical implications.

MOLECULAR NEUROBIOLOGY (2022)

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Article Medicine, Research & Experimental

MicroRNA-4722-5p and microRNA-615-3p serve as potential biomarkers for Alzheimer's disease

Yan Liu et al.

Summary: The aim of this study was to investigate the expression levels and diagnostic value of microRNA(miR)-4722-5p and miR-615-3p in Alzheimer's disease (AD). The results showed that the expression levels of miR-4722-5p and miR-615-3p were increased in AD patients and cell models. The expression levels of these two miRNAs were negatively correlated with MMSE scores, and their combination had a better diagnostic value for AD. Functional enrichment analysis revealed the involvement of miR-4722-5p in processes such as protein folding and cell division, while miR-615-3p was involved in transcription regulation and protein phosphorylation. These findings suggest that miR-4722-5p and miR-615-3p may serve as potential biomarkers for early diagnosis of AD.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2022)

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Review Neurosciences

MicroRNA-21 Is a Versatile Regulator and Potential Treatment Target in Central Nervous System Disorders

Xue Bai et al.

Summary: MiR-21 has emerged as a versatile regulator in central nervous system disorders, particularly in the regulation of apoptosis and inflammation. Understanding the mechanisms of miR-21 in CNS disorders could lead to its potential as a therapeutic target.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2022)

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Article Clinical Neurology

Expression relationship and significance of NEAT1 and miR-27a-3p in serum and cerebrospinal fluid of patients with Alzheimer's disease

Lijie He et al.

Summary: This study investigated the expression relationship and significance of long chain non-coding RNA NEAT1 and miR-27a-3p in the serum and cerebrospinal fluid of patients with Alzheimer's disease (AD). The results showed that NEAT1 levels were increased and miR-27a-3p levels were decreased in AD patients, and the levels of NEAT1 and miR-27a-3p were correlated with the degree of A beta deposition in the brain of AD patients.

BMC NEUROLOGY (2022)

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Review Biochemistry & Molecular Biology

Molecular Biomarkers and Their Implications for the Early Diagnosis of Selected Neurodegenerative Diseases

Julia Doroszkiewicz et al.

Summary: The degeneration and dysfunction of neurons are key features of neurodegenerative diseases. Researchers and clinicians face challenges in early diagnosis and detection of neuronal dysfunction. miRNAs and extracellular microvesicles may serve as potential biomarkers for diagnosis and research of neurodegenerative diseases, but there are limitations to their use.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Neurosciences

Age-related Huntington's disease progression modeled in directly reprogrammed patient-derived striatal neurons highlights impaired autophagy

Young Mi Oh et al.

Summary: This study investigated the mechanism of neurodegeneration in patients with Huntington's disease (HD) and found that age-associated upregulation of miR-29b-3p impairs autophagy and leads to neuronal degeneration. The researchers also demonstrated that reducing miR-29b-3p or promoting autophagy can increase the resilience of HD-MSNs against neurodegeneration.

NATURE NEUROSCIENCE (2022)

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Article Chemistry, Analytical

Ultrasensitive photoelectrochemical biosensor based on black/red phosphorus heterojunction@Bi2Te3 hybrid and enzymatic signal amplification for the detection of colorectal cancer-related piRNA-823

Zhiwei Sun et al.

Summary: This study proposes a new method for ultrasensitive liquid biopsy of piRNAs using a photoelectrochemical biosensor. The biosensor shows excellent photoelectric conversion performance and stable photocurrent response, and can accurately distinguish healthy controls from CRC patients.

SENSORS AND ACTUATORS B-CHEMICAL (2022)

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Article Cardiac & Cardiovascular Systems

Prognostic Value of Machine Learning in Patients with Acute Myocardial Infarction

Changhu Xiao et al.

Summary: Patients with acute myocardial infarction (AMI) often experience major adverse cardiovascular events. This study aimed to assess the predictive value of machine learning (ML) in predicting these events. Independent predictors of adverse cardiovascular events were identified using logistic regression analysis. The random forest (RDF) model showed the best performance in predicting these events.

JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE (2022)

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Article Biology

Selectivity of Lewy body protein interactions along the aggregation pathway of α-synuclein

Andre D. G. Leitao et al.

Summary: The study presents a method to measure interactions of different forms of alpha-synuclein with 65 proteins, revealing the sequence of protein-binding events that lead to alpha-synuclein aggregation and providing potential targets for the treatment of synucleinopathies.

COMMUNICATIONS BIOLOGY (2021)

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Review Neurosciences

The Relation of the Brain-Derived Neurotrophic Factor with MicroRNAs in Neurodegenerative Diseases and Ischemic Stroke

Ceren Eyileten et al.

Summary: BDNF plays a crucial role in nervous system development and the pathogenesis of neurodegenerative diseases, while miRNAs may serve as potential biomarkers and therapeutic targets.

MOLECULAR NEUROBIOLOGY (2021)

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Article Chemistry, Multidisciplinary

A novel aptamer-based histochemistry assay for specific diagnosis of clinical breast cancer tissues

Mei Liu et al.

Summary: The aptahistochemistry assay developed in this study can accurately distinguish different molecular subtypes of breast cancer, with a high accuracy of up to 80% in diagnosing Luminal A breast cancer, showing great potential for clinical pathological diagnosis applications.

CHINESE CHEMICAL LETTERS (2021)

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Review Chemistry, Multidisciplinary

Current signal amplification strategies in aptamer-based electrochemical biosensor: A review

Lei He et al.

Summary: Aptamers have high specificity and affinity toward various targets, making them widely used in analytical techniques. In order to improve biosensor sensitivity, different amplification strategies are being explored, such as using nanomaterials or enzyme mimics.

CHINESE CHEMICAL LETTERS (2021)

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Review Geriatrics & Gerontology

Parkinson's disease and microRNAs-Lessons from model organisms and human studies

Brian Evans et al.

Summary: Parkinson's disease is a progressive neurodegenerative disorder with a lack of early diagnosis and treatment options. Recent studies have focused on microRNAs as therapeutic targets in various diseases, including Parkinson's disease, and have identified specific roles for microRNAs in the pathogenesis and progression of PD in several model organisms.

EXPERIMENTAL GERONTOLOGY (2021)

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Article Neurosciences

The promise of microRNA-based therapies in Alzheimer's disease: challenges and perspectives

Hannah Walgrave et al.

Summary: Researchers review the regulation of microRNAs in the pathophysiology of Alzheimer's disease and critically discuss the potential for developing microRNA-based therapeutics using these insights.

MOLECULAR NEURODEGENERATION (2021)

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Article Neurosciences

Circulating miR-181 is a prognostic biomarker for amyotrophic lateral sclerosis

Iddo Magen et al.

Summary: The study identified miRNA-based biomarkers in the blood of ALS patients, with miR-181 levels alone or in combination with established protein biomarkers predicting disease severity and prognosis. This approach may enhance the power of clinical trials for ALS and improve patient stratification accuracy.

NATURE NEUROSCIENCE (2021)

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Review Medicine, General & Internal

Alzheimer's disease

Philip Scheltens et al.

Summary: Alzheimer's disease is projected to see a significant increase in prevalence in the future, with genetics playing a key role. Novel biomarkers and lifestyle-based prevention trials show promising therapeutic potential. Promising pharmacological treatments are advancing in clinical trials, targeting amyloid beta, tau, and inflammation.

LANCET (2021)

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Article Cell Biology

The role of exosomal microRNAs in central nervous system diseases

Yifei Yu et al.

Summary: miRNAs play a crucial role in regulating gene expression, while the exchange of miRNAs within exosomes is important in CNS diseases. Exosomal miRNAs can serve as a novel therapeutic strategy and diagnostic tool for neurological diseases.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2021)

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Review Neurosciences

Circulating MicroRNAs and Long Non-coding RNAs as Potential Diagnostic Biomarkers for Parkinson's Disease

Yimin Yang et al.

Summary: Parkinson's disease is a common neurodegenerative disease associated with age, leading to loss of self-care ability for patients and burden on families and society. Research on abnormal expression of miRNAs and lncRNAs in circulating fluids is significant for understanding the pathogenesis of PD and developing objective diagnostic methods.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2021)

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Article Biochemistry & Molecular Biology

Unravelling the Role of LncRNA WT1-AS/miR-206/NAMPT Axis as Prognostic Biomarkers in Lung Adenocarcinoma

Wen Li et al.

Summary: The study investigates the role of the key oncogene MYC in the pathogenesis of lung adenocarcinoma (LUAD) and identifies the WT1-AS/miR-206/NAMPT axis as potentially important prognostic factors associated with the diagnosis and prognosis of LUAD.

BIOMOLECULES (2021)

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Article Cell Biology

Enhanced Expression of microRNA-1273g-3p Contributes to Alzheimer's Disease Pathogenesis by Regulating the Expression of Mitochondrial Genes

So Hee Kim et al.

Summary: The research identified miR-1273g-3p as an AD-associated miRNA that is elevated in the CSF of early-stage AD patients and enhances Aβ production and mitochondrial impairments. Through a biotin-streptavidin pull-down assay, it was demonstrated that miR-1273g-3p primarily interacts with mitochondrial genes, leading to their downregulation. Target gene analysis showed reduced expression of TIMM13 in brain tissues from human AD patients, indicating that miR-1273g-3p plays a role in early AD pathogenesis.

CELLS (2021)

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Article Nanoscience & Nanotechnology

Fast and Accurate Control Strategy for Portable Nucleic Acid Detection (PNAD) System Based on Magnetic Nanoparticles

Yile Fang et al.

Summary: The dual-channel temperature controller for PNAD systems plays a crucial role in providing fast and accurate temperature control for both sample processing and PCR, resulting in improved concentration and purity of the extraction product and increased amplification efficiency.

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY (2021)

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Article Nanoscience & Nanotechnology

Highly Fluorescent N-Doped Carbon Quantum Dots Derived from Bamboo Stems for Selective Detection of Fe3+ Ions in Biological Systems

Jiamin Yan et al.

Summary: A highly fluorescent Fe3+ sensitive fluorescent nanoprobe was constructed using N-doped carbon quantum dots (NCQDs) derived from bamboo stems through a hydrothermal method. The NCQDs showed high fluorescence quantum yield and stability, with a linear response to Fe3+ concentration in the range of 0.01-10 μM and a detection limit of 0.486 μM, indicating high sensitivity to Fe3+ ions. These properties make NCQDs promising for clinical diagnostics and biologically relevant studies.

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY (2021)

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Article Neurosciences

Aberrant expression of miR-148a-3p in Alzheimer's disease and its protective role against amyloid-β induced neurotoxicity

Hao Zhang et al.

Summary: In this study, the expression of miR-148a-3p was found to be downregulated in AD patients, positively correlated with MMSE score, and potentially useful for AD diagnosis. Overexpression of miR-148a-3p attenuated Aβ-induced neurotoxicity in AD by targeting ROCK1.

NEUROSCIENCE LETTERS (2021)

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Article Health Care Sciences & Services

An Australian Neuro-Palliative perspective on Huntington's disease: a case report

Rajvi Shah et al.

Summary: Huntington's Disease is an incurable, progressive neuro-degenerative disease with limited access to palliative care services for patients. Through a case study of a late-stage HD patient, it is emphasized that there is a need to improve the accessibility of neuro-palliative care services to help more patients receive comprehensive care.

BMC PALLIATIVE CARE (2021)

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Review Neurosciences

MicroRNA Dysregulation in Parkinson's Disease: A Narrative Review

Yong Hui Nies et al.

Summary: Parkinson's disease is a severely debilitating neurodegenerative disease that affects the motor system, with mechanisms of pathogenesis still unclear. MicroRNAs play a crucial role in the regulation of PD-associated genes, dopaminergic neuron survival, and inflammation, potentially serving as diagnostic biomarkers and therapeutic tools for PD.

FRONTIERS IN NEUROSCIENCE (2021)

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Article Neurosciences

MiR-216a-5p ameliorates learning-memory deficits and neuroinflammatory response of Alzheimer's disease mice via regulation of HMGB1/NF-κB signaling

Peng Shao

Summary: The study showed that miR-216a-5p can improve learning-memory ability and reduce the inflammatory response of AD mice by inhibiting the HMGB1/NF-kappa B pathway. Treatment with miR-216a-5p significantly improved various parameters in AD mice, including decreasing A beta deposition, increasing Nissl-positive cell count, and reducing TUNEL-positive cells.

BRAIN RESEARCH (2021)

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Review Chemistry, Multidisciplinary

The point-of-care-testing of nucleic acids by chip, cartridge and paper sensors

Yuyue Xu et al.

Summary: Point-of-care nucleic acid testing (POCNAT) plays a crucial role in infectious disease outbreaks, offering rapid, simple, and automated detection of nucleic acid. Leveraging advancements in technology, novel experimental carriers like chips, cartridges, and papers have been employed for automated nucleic acid detection, marking significant progress in the field.

CHINESE CHEMICAL LETTERS (2021)

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Article Nanoscience & Nanotechnology

Rapid Detection of DNA Methylation with a Novel Real-Time Fluorescence Recombinase-Aided Amplification Assay

Ziyu He et al.

Summary: The study introduces a novel method for rapid quantitative detection of DNA methylation, showing great potential for clinical application in quickly and easily conducting methylation analysis.

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY (2021)

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Review Neurosciences

Alzheimer's Disease and microRNA-132: A Widespread Pathological Factor and Potential Therapeutic Target

Meng Zhang et al.

Summary: Alzheimer's disease is a common neurodegenerative disease in the elderly, characterized by gradual cognitive decline and personality changes. The role of miR-132 in regulating AD-related genes, particularly in the progression of Aβ and tau pathology, has been highlighted in recent studies. Decreased circulating miR-132 levels may serve as a potential diagnostic biomarker for AD.

FRONTIERS IN NEUROSCIENCE (2021)

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Review Cell Biology

Altered microRNA expression in animal models of Huntington's disease and potential therapeutic strategies

Bridget Martinez et al.

Summary: Studies have shown that regulation of certain microRNAs in animal models and cell studies can improve symptoms of Huntington's disease, increase survival rates, and inhibit the production of mutant huntingtin protein.

NEURAL REGENERATION RESEARCH (2021)

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Review Nanoscience & Nanotechnology

Two-Photon Fluorescent Nanomaterials and Their Applications in Biomedicine

Liang Gong et al.

Summary: This article reviews recent advances in the field of two-photon fluorescent nanomaterials, highlighting their applications in biomedical field such as biosensing, imaging, and therapy. It introduces the optical properties, synthetic methods, and important applications of TPE nanomaterials including organic molecules, quantum dots, carbon dots, and metal nanoclusters. The challenges and future prospects in the development of two-photon fluorescent nanomaterials are also discussed.

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY (2021)

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Article Clinical Neurology

Serum miR-128 Serves as a Potential Diagnostic Biomarker for Alzheimer's Disease

Ming Zhang et al.

Summary: The study found that miR-128 was significantly upregulated in serum samples of AD patients and negatively correlated with MMSE scores. MiR-128 showed good diagnostic performance when used alone or in combination with other factors. Serum miR-128 levels were positively correlated with inflammatory factors IL-113 and TNF-alpha levels.

NEUROPSYCHIATRIC DISEASE AND TREATMENT (2021)

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Article Neurosciences

Exosome-encapsulated microRNAs as promising biomarkers for Alzheimer's disease

Jian-jiao Chen et al.

REVIEWS IN THE NEUROSCIENCES (2020)

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Article Clinical Neurology

MiR-340 Reduces the Accumulation of Amyloid-β Through Targeting BACE1 (β-site Amyloid Precursor Protein Cleaving Enzyme 1) in Alzheimer's Disease

Xianpei Tan et al.

CURRENT NEUROVASCULAR RESEARCH (2020)

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Article Clinical Neurology

MiR-335-5p Inhibits β-Amyloid (Aβ) Accumulation to Attenuate Cognitive Deficits Through Targeting c-jun-N-terminal Kinase 3 in Alzheimer's Disease

Dan Wang et al.

CURRENT NEUROVASCULAR RESEARCH (2020)

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Article Neurosciences

microRNA-592 blockade inhibits oxidative stress injury in Alzheimer's disease astrocytes via the KIAA0319-mediated Keap1/Nrf2/ARE signaling pathway

Guo-De Wu et al.

EXPERIMENTAL NEUROLOGY (2020)

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Article Clinical Neurology

MicroRNA-425-5p promotes tau phosphorylation and cell apoptosis in Alzheimer's disease by targeting heat shock protein B8

Jiao Yuan et al.

JOURNAL OF NEURAL TRANSMISSION (2020)

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Article Biotechnology & Applied Microbiology

A Computational Study of Potential miRNA-Disease Association Inference Based on Ensemble Learning and Kernel Ridge Regression

Li-Hong Peng et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2020)

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Article Clinical Neurology

Overexpression of miR-26a-5p Suppresses Tau Phosphorylation and Aβ Accumulation in the Alzheimer's Disease Mice by Targeting DYRK1A

Yanni Liu et al.

CURRENT NEUROVASCULAR RESEARCH (2020)

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Review Neurosciences

miR-129-5p: A key factor and therapeutic target in amyotrophic lateral sclerosis

Alessia Loffreda et al.

PROGRESS IN NEUROBIOLOGY (2020)

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Review Biotechnology & Applied Microbiology

Application of magnetic nanoparticles in nucleic acid detection

Congli Tang et al.

JOURNAL OF NANOBIOTECHNOLOGY (2020)

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Article Neurosciences

MiR-539-5p Decreases amyloid β-protein production, hyperphosphorylation of Tau and Memory Impairment by Regulating PI3K/Akt/GSK-3β Pathways in APP/PS1 Double Transgenic Mice

Yushu Jiang et al.

NEUROTOXICITY RESEARCH (2020)

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Review Neurosciences

Salivary Biomarkers: Future Approaches for Early Diagnosis of Neurodegenerative Diseases

Giovanni Schepici et al.

BRAIN SCIENCES (2020)

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Review Neurosciences

Towards an improved early diagnosis of neurodegenerative diseases: the emerging role of in vitro conversion assays for protein amyloids

Niccolo Candelise et al.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2020)

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Article Clinical Neurology

miR-34a-5p and miR-125b-5p attenuate Aβ-induced neurotoxicity through targeting BACE1

Pengxiang Li et al.

JOURNAL OF THE NEUROLOGICAL SCIENCES (2020)

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Article Medicine, Research & Experimental

miR-132 improves the cognitive function of rats with Alzheimer's disease by inhibiting the MAPK1 signal pathway

Yiming Deng et al.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2020)

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Review Nanoscience & Nanotechnology

Recent Progress in Black Phosphorus Sensors

Tingting Ma et al.

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY (2020)

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Article Neurosciences

Isovitexin modulates autophagy in Alzheimer's disease via miR-107 signalling

Jiang Cheng et al.

TRANSLATIONAL NEUROSCIENCE (2020)

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Review Cell Biology

Functional roles and networks of non-coding RNAs in the pathogenesis of neurodegenerative diseases

Yi-Ying Wu et al.

JOURNAL OF BIOMEDICAL SCIENCE (2020)

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Article Neurosciences

被撤回的出版物: Isovitexin modulates autophagy in Alzheimer's disease via miR-107 signalling (Retracted article. See vol. 13, pg. 407, 2022)

Jiang Cheng et al.

TRANSLATIONAL NEUROSCIENCE (2020)

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Article Neurosciences

MiR-105 and miR-9 regulate the mRNA stability of neuronal intermediate filaments. Implications for the pathogenesis of amyotrophic lateral sclerosis (ALS)

Zachary C. E. Hawley et al.

BRAIN RESEARCH (2019)

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Article Neurosciences

MicroRNA-132 in the Adult Dentate Gyrus is Involved in Opioid Addiction Via Modifying the Differentiation of Neural Stem Cells

Meng Jia et al.

NEUROSCIENCE BULLETIN (2019)

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Review Clinical Neurology

Suicidal ideation and behavior in Huntington's disease: Systematic review and recommendations

Zachary R. Kachiand et al.

JOURNAL OF AFFECTIVE DISORDERS (2019)

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Article Clinical Neurology

The long-non-coding RNA NEAT1 is a novel target for Alzheimer's disease progression via miR-124/BACE1 axis

Mei-Ying Zhao et al.

NEUROLOGICAL RESEARCH (2019)

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Review Neurosciences

Amyloid Beta and MicroRNAs in Alzheimer's Disease

Nnana Amakiri et al.

FRONTIERS IN NEUROSCIENCE (2019)

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Article Nanoscience & Nanotechnology

A Highly Sensitive Strategy for Low-Abundance Hepatitis B Virus Detection via One-Step Nested Polymerase Chain Reaction, Chemiluminescence Technology and Magnetic Separation

Xianbo Mou et al.

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY (2019)

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Article Biochemistry & Molecular Biology

MicroRNA-25 aggravates Aβ1-42-induced hippocampal neuron injury in Alzheimer's disease by downregulating KLF2 via the Nrf2 signaling pathway in a mouse model

Qiang Duan et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2019)

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Article Multidisciplinary Sciences

Circulatory miR-223-3p Discriminates Between Parkinson's and Alzheimer's Patients

Roberta Mancuso et al.

SCIENTIFIC REPORTS (2019)

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Article Pharmacology & Pharmacy

MicroRNA-200a-3p Mediates Neuroprotection in Alzheimer-Related Deficits and Attenuates Amyloid-Beta Overproduction and Tau Hyperphosphorylation via Coregulating BACE1 and PRKACB

Linlin Wang et al.

FRONTIERS IN PHARMACOLOGY (2019)

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Article Cell Biology

Deregulated miR-29b-3p Correlates with Tissue-Specific Activation of Intrinsic Apoptosis in An Animal Model of Amyotrophic Lateral Sclerosis

Christina L. Klatt et al.

CELLS (2019)

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Article Biology

Down-regulation of microRNA-200b is a potential prognostic marker of lung cancer in southern-central Chinese population

Wen Li et al.

SAUDI JOURNAL OF BIOLOGICAL SCIENCES (2019)

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Review Biochemistry & Molecular Biology

Interplay between MicroRNAs and Oxidative Stress in Neurodegenerative Diseases

Julia Konovalova et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Neurosciences

miR-212 and miR-132 Are Downregulated in Neurally Derived Plasma Exosomes of Alzheimer's Patients

Diana J. Cha et al.

FRONTIERS IN NEUROSCIENCE (2019)

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Article Chemistry, Multidisciplinary

Cell microarray chip system for accurate, rapid diagnosis and target treatment of breast cancer cells SK-BR-3

Ting Wang et al.

CHINESE CHEMICAL LETTERS (2019)

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Article Pharmacology & Pharmacy

MicroRNA-128 knockout inhibits the development of Alzheimer's disease by targeting PPARγ in mouse models

Yanqiu Liu et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2019)

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Review Cell Biology

MicroRNAs as regulators of cell death mechanisms in amyotrophic lateral sclerosis

Delia Gagliardi et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2019)

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Review Biochemistry & Molecular Biology

Deciphering miRNAs' Action through miRNA Editing

Marta Correia de Sousa et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Clinical Neurology

Global, regional, and national burden of Alzheimer's disease and other dementias, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016

Emma Nichols et al.

LANCET NEUROLOGY (2019)

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Review Biochemistry & Molecular Biology

Post-transcriptional control of miRNA biogenesis

Gracjan Michlewski et al.

RNA (2019)

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Article Medicine, Research & Experimental

Intranasal Administration of miR-146a Agomir Rescued the Pathological Process and Cognitive Impairment in an AD Mouse Model

Hui Mai et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2019)

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Review Biochemistry & Molecular Biology

MicroRNAs in Neuroinflammation: Implications in Disease Pathogenesis, Biomarker Discovery and Therapeutic Applications

Jessy A. Slota et al.

NON-CODING RNA (2019)

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Article Medicine, General & Internal

Long Noncoding RNA NEAT1 Aggravates Aβ-Induced Neuronal Damage by Targeting miR-107 in Alzheimer's Disease

Sha Ke et al.

YONSEI MEDICAL JOURNAL (2019)

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Review Biochemistry & Molecular Biology

MicroRNA in Brain pathology: Neurodegeneration the Other Side of the Brain Cancer

Jakub Godlewski et al.

NON-CODING RNA (2019)

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Article Geriatrics & Gerontology

Clinical and Genetic Profiles in Chinese Patients with Huntington's Disease: A Ten-year Multicenter Study in China

Hong-Lei Li et al.

AGING AND DISEASE (2019)

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Article Biochemistry & Molecular Biology

Screening the expression characteristics of several miRNAs in G93A-SOD1 transgenic mouse: altered expression of miRNA-124 is associated with astrocyte differentiation by targeting Sox2 and Sox9

Fenghua Zhou et al.

JOURNAL OF NEUROCHEMISTRY (2018)

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Article Neurosciences

Fifty-Hertz Magnetic Field Affects the Epigenetic Modulation of the miR-34b/c in Neuronal Cells

Claudia Consales et al.

MOLECULAR NEUROBIOLOGY (2018)

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Article Clinical Neurology

MicroRNAs in CSF as prodromal biomarkers for Huntington disease in the PREDICT-HD study

Eric R. Reed et al.

NEUROLOGY (2018)

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Article Cell Biology

Clinical Neurology and Epidemiology of the Major Neurodegenerative Diseases

Michael G. Erkkinen et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2018)

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Article Clinical Neurology

MicroRNA-132 provides neuroprotection for tauopathies via multiple signaling pathways

Rachid El Fatimy et al.

ACTA NEUROPATHOLOGICA (2018)

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Article Cell Biology

The Role of MiR-132 in Regulating Neural Stem Cell Proliferation, Differentiation and Neuronal Maturation

Dong Chen et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2018)

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Article Allergy

MicroRNA

Thomas X. Lu et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2018)

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Article Nanoscience & Nanotechnology

A Portable Multi-Channel Turbidity System for Rapid Detection of Pathogens by Loop-Mediated Isothermal Amplification

Zhu Chen et al.

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY (2018)

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Article Nanoscience & Nanotechnology

Single-Nucleotide Polymorphism Genotyping of exoS in Pseudomonas aeruginosa Using Dual-Color Fluorescence Hybridization and Magnetic Separation

Yongjun Tang et al.

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY (2018)

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Review Nanoscience & Nanotechnology

Immunosensors Based on Nanomaterials for Detection of Tumor Markers

Yuxuan Lai et al.

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY (2018)

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Article Neurosciences

Perturbations in the p53/miR-34a/SIRT1 pathway in the R6/2 Huntington's disease model

Regina Hertfelder Reynolds et al.

MOLECULAR AND CELLULAR NEUROSCIENCE (2018)

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Article Toxicology

Manganese exposure: Linking down-regulation of miRNA-7 and miRNA-433 with α-synuclein overexpression and risk of idiopathic Parkinson's disease

Prashant Tarale et al.

TOXICOLOGY IN VITRO (2018)

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Article Multidisciplinary Sciences

Differential expression of microRNAs and other small RNAs in muscle tissue of patients with ALS and healthy age-matched controls

Anja Kovanda et al.

SCIENTIFIC REPORTS (2018)

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Review Genetics & Heredity

The Role of microRNAs in Alzheimer's Disease and Their Therapeutic Potentials

Munvar Miya Shaik et al.

GENES (2018)

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Article Medicine, Research & Experimental

Supplemental Treatment for Huntington's Disease with miR-132 that Is Deficient in Huntington's Disease Brain

Masashi Fukuoka et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2018)

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Article Biophysics

Manganese dioxide Nanorods/electrochemically reduced graphene oxide nanocomposites modified electrodes for cost-effective and ultrasensitive detection of Amaranth

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