Journal
BIOSENSORS-BASEL
Volume 12, Issue 12, Pages -Publisher
MDPI
DOI: 10.3390/bios12121160
Keywords
microfluidics; automation; micromechanical valves
Funding
- NIH [HD100251, DK084567]
- Center for Biomedical Discovery, the Office of Translation to Practice and Cells to Cures Strategic Initiative at Mayo Clinic
Ask authors/readers for more resources
We present a control system for operating valve-enabled microfluidic devices and demonstrate its use in a complex workflow involving plasma separation and mixing. The control system includes pumps, pressure sensors, a microcontroller, solenoid valves, and off-the-shelf components, allowing precise fluid flow control.
We describe a control system for operating valve-enabled microfluidic devices and leverage this control system to carry out a complex workflow of plasma separation from 8 mu L of whole blood followed by on-chip mixing of plasma with assay reagents for biomarker detection. The control system incorporates pumps, digital pressure sensors, a microcontroller, solenoid valves and off-the-shelf components to deliver high and low air pressure in the desired temporal sequence to meter fluid flow and actuate microvalves. Importantly, our control system is portable, which is suitable for operating the microvalve-enabled microfluidic devices in the point-of-care setting.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
