☆ 4.7 Review

Biomedical Applications of Microfluidic Devices: A Review

BIOSENSORS-BASEL (2022)

Related references

Note: Only part of the references are listed.
Review Biochemistry & Molecular Biology

Urea biosensors: A comprehensive review

Sunil N. Botewad et al.

Summary: This study focuses on recent advances in biosensors for detecting and measuring urea concentration. Urea is found naturally in various processes and is a byproduct of nitrogen metabolism in the human body. Abnormal urea concentration can lead to serious diseases, while low levels can cause other health issues. The study explores the use of nanoparticles, conducting polymers, and carbon materials in urea biosensors. The aim is to provide comprehensive information on the sensing parameters of these biosensors and to serve as a valuable resource for researchers in the field.

BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY (2023)

Add to Collection
Review Biotechnology & Applied Microbiology

The revolution of PDMS microfluidics in cellular biology

Soumyabrata Banik et al.

Summary: Microfluidics revolutionizes cellular biology research by providing control over the physicochemical environment and enabling high-throughput cellular analysis. The introduction of PDMS as a structural material has made microfluidic technology more accessible and widely applicable in various biological fields. This review emphasizes the innovative applications of PDMS-based microfluidic systems in pre-clinical biological research, enhancing sensitivity and diagnostic effectiveness in cell-based assays.

CRITICAL REVIEWS IN BIOTECHNOLOGY (2023)

Add to Collection
Article Engineering, Biomedical

Endothelialized microvessels fabricated by microfluidics facilitate osteogenic differentiation and promote bone repair

Jiayuan Wang et al.

Summary: Vascularization is a critical factor in bone tissue engineering, and lack of endothelialization remains a challenge. This study developed a technique to fabricate endothelialized biomimetic microvessels using microfluidic technology, which showed promising results in promoting osteogenesis and bone regeneration both in vitro and in vivo. These findings suggest that endothelialized BMVs could be an effective strategy in bone tissue engineering.

ACTA BIOMATERIALIA (2022)

Add to Collection
Review Chemistry, Multidisciplinary

Microfluidic Tissue Engineering and Bio-Actuation

Miriam Filippi et al.

Summary: Bio-hybrid technologies aim to replicate the unique capabilities of biological systems, and soft bio-hybrid robots have the potential to self-assemble, regenerate, work autonomously, and interact safely with other species and the environment. Microfluidic techniques are crucial for engineering biological tissues and achieving fine structuring and regulation at the microscale.

ADVANCED MATERIALS (2022)

Add to Collection
Article Chemistry, Multidisciplinary

A Biomimetic Human Lung-on-a-Chip with Colorful Display of Microphysiological Breath

Yujuan Zhu et al.

Summary: In this study, a novel biomimetic 3D microphysiological lung-on-a-chip system with breathing visualization was developed. The system, inspired by the iridescence phenomenon of soap bubbles, allows for the cyclic deformation of pulmonary alveoli and real-time monitoring of cell mechanics. The research also reveals the essential role of mechanical stretching in idiopathic pulmonary fibrosis.

ADVANCED MATERIALS (2022)

Add to Collection
Article Chemistry, Multidisciplinary

Magnetic Soft Millirobots 3D Printed by Circulating Vat Photopolymerization to Manipulate Droplets Containing Hazardous Agents for In Vitro Diagnostics

Aiwu Zhou et al.

Summary: By utilizing a circulating vat photopolymerization platform, magnetic soft millirobots (MSMRs) with high magnetic response can be 3D printed with high accuracy, showcasing their reversible 3D-to-3D transformation and liquid droplet manipulation capabilities, broadening their application in in vitro diagnostics.

ADVANCED MATERIALS (2022)

Add to Collection
Article Chemistry, Analytical

Dry-reagent microfluidic biosensor for simple detection of NT-proBNP via Ag nanoparticles

Franziska Beck et al.

Summary: The microfluidic biosensor has key characteristics of desirable home-tests, including low limits of detection, small sample volume, simple detection strategies, and long-term stable reagents. It can accurately assess the severity and progression of diseases.

ANALYTICA CHIMICA ACTA (2022)

Add to Collection
Article Biochemical Research Methods

A pump-free microfluidic device for fast magnetic labeling of ischemic stroke biomarkers

Briliant Adhi Prabowo et al.

Summary: This research proposes a low-cost and simple microfluidic chip for enhancing the magnetic labeling efficiency of ischemic stroke biomarkers. The chip operates based on capillary attractions without external power sources, using an integrated cellulose sponge to absorb samples and a magnetic field to hold the target labeled by magnetic nanoparticles. The study successfully optimized the labeling efficiency, making it a potential tool for clinical sample preparation and specific magnetic target labeling.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2022)

Add to Collection
Article Chemistry, Analytical

A Flexible Microfluidic Chip-Based Universal Fully Integrated Nanoelectronic System with Point-of-Care Raw Sweat, Tears, or Saliva Glucose Monitoring for Potential Noninvasive Glucose Management

Mimi Sun et al.

Summary: This article demonstrates a fully integrated nanoelectronic system that combines a flexible and disposable microfluidic enzymatic biosensor with a handheld wireless electronic device to monitor glucose in various raw noninvasive biofluids. The system shows potential utility in noninvasive glucose management for both healthy individuals and diabetic patients, and has the capability to expand to the monitoring of other biomolecules.

ANALYTICAL CHEMISTRY (2022)

Add to Collection
Article Chemistry, Analytical

Capacitive Aptasensor Coupled with Microfluidic Enrichment for Real-Time Detection of Trace SARS-CoV-2 Nucleocapsid Protein

Haochen Qi et al.

Summary: A fast-responding and quantitative capacitive aptasensor has been developed for ultratrace nucleocapsid protein detection. The sensor has a quick response time, high sensitivity, and high selectivity, meeting the real-time detection demand.

ANALYTICAL CHEMISTRY (2022)

Add to Collection
Article Biochemistry & Molecular Biology

A Distance-Based Microfluidic Paper-Based Biosensor for Glucose Measurements in Tear Range

Samira Allameh et al.

Summary: The prevalence of diabetes has increased, highlighting the need for minimally invasive, user-friendly, and cost-effective glucose biosensors in low-income and developing countries. This paper presents a microfluidic paper-based analytical device (mu PAD) for detecting glucose concentration in tears, which can be observed with the naked eye. The device is affordable, does not require trained personnel, and offers quick results.

APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY (2022)

Add to Collection
Article Engineering, Biomedical

Organ-on-a-chip model of vascularized human bone marrow niches

Drew E. Glaser et al.

Summary: A 3D in vitro model of human bone marrow containing perivascular and endosteal niches has been developed using microfluidic and stem cell technologies. This model can replicate in vivo bone marrow function and study dynamic events at the niche level, providing opportunities to advance our understanding of human bone marrow function and drug response.

BIOMATERIALS (2022)

Add to Collection
Article Respiratory System

Modeling pulmonary cystic fibrosis in a human lung airway-on-a-chip

Roberto Plebani et al.

Summary: This study developed a microfluidic device using organ-on-a-chip technology to replicate the features of human cystic fibrosis (CF) lungs. The device successfully captured CF airway characteristics, including mucus accumulation, increased cilia density, and faster ciliary beating frequency. Additionally, it simulated the inflammatory response and infection levels in CF patients, as well as provided a conducive environment for the growth of Pseudomonas aeruginosa.

JOURNAL OF CYSTIC FIBROSIS (2022)

Add to Collection
Article Biochemical Research Methods

Intestinal explant barrier chip: long-term intestinal absorption screening in a novel microphysiological system using tissue explants

Hossein Eslami Amirabadi et al.

Summary: The IEBC is a novel screening platform that benefits from the complexity of tissue explants and the flow in microfluidic chips, improving the prediction of drug absorption in the intestine by extending tissue viability in a dynamic microfluidic environment. Studying tissue function, integrity, and viability allows for accurate prediction of drug absorption in the intestine.

LAB ON A CHIP (2022)

Add to Collection
Article Biochemical Research Methods

Acoustic bubble for spheroid trapping, rotation, and culture: a tumor-on-a-chip platform (ABSTRACT platform)

Yuan Gao et al.

Summary: The study presents an acoustic bubble-based system for the isolation, trapping, rotation, and culture of circulating tumor cells (CTCs). The system utilizes microcavities and culture chambers to simplify the process and improve the efficiency of CTC processing. The controlled acoustic bubble allows continuous trapping and rotation of CTCs, enabling downstream analysis and personalized drug testing.

LAB ON A CHIP (2022)

Add to Collection
Article Biochemical Research Methods

Analysis of the effects of aryl hydrocarbon receptor expression on cancer cell invasion via three-dimensional microfluidic invasion assays

Bingyu B. Li et al.

Summary: The study reveals that the expression level of AHR affects the invasiveness of breast cancer cells, with AHR knockout enhancing invasive characteristics and AHR overexpression reducing invasiveness. The results suggest a potential role of AHR in regulating invasion and metastasis in breast cancer.

LAB ON A CHIP (2022)

Add to Collection
Article Biochemical Research Methods

Microfluidic organ-on-chip system for multi-analyte monitoring of metabolites in 3D cell cultures

Johannes Dornhof et al.

Summary: The study introduced a microfluidic organ-on-chip platform for matrix-based, heterogeneous 3D cell cultures with integrated electrochemical sensors for metabolites. The system allowed precise control of culture conditions and real-time multi-analyte metabolite monitoring, demonstrating potential applications in personalized medicine and cancer research.

LAB ON A CHIP (2022)

Add to Collection
Article Biochemical Research Methods

A novel magnetophoretic-based device for magnetometry and separation of single magnetic particles and magnetized cells

Roozbeh Abedini-Nassab et al.

Summary: The use of magnetic micro- and nanoparticles in medicine and biology is expanding, with one important example being the transport of these particles in lab-on-a-chip systems. This study introduces a novel magnetometer using magnetic micro-disks to evaluate the magnetic susceptibility of numerous individual particles simultaneously. The method has various crucial applications, including magnetic characterization of beads and living cells, determining magnetization rate of cells, evaluating degradation rate of nanoparticles in cells, detecting target cells in samples, and separating particles based on size and magnetic susceptibility.

LAB ON A CHIP (2022)

Add to Collection
Article Biochemical Research Methods

Microscale impeller pump for recirculating flow in organs-on-chip and microreactors

Sophie R. Cook et al.

Summary: The impeller pump, utilizing a 3D-printed device and impeller to recirculate fluid and cells on-chip driven by magnets generating a rotating magnetic field, successfully mimics biomimetic fluid velocities in microchannels while maintaining physiological shear stress.

LAB ON A CHIP (2022)

Add to Collection
Article Nanoscience & Nanotechnology

The role of channel height and actuation method on particle manipulation in surface acoustic wave (SAW)-driven microfluidic devices

Citsabehsan Devendran et al.

Summary: Surface acoustic wave (SAW) micromanipulation offers modularity, easy integration into microfluidic devices and a high degree of flexibility. However, reducing the threshold for manipulating smaller particles is a major challenge. The novel excitation configuration based on diffractive-acoustic SAW (DASAW) actuation shows promise in reducing the critical minimum particle size that can be manipulated, with the ability to tune the streaming magnitude by changing the channel height.

MICROFLUIDICS AND NANOFLUIDICS (2022)

Add to Collection
Review Chemistry, Analytical

Surface Acoustic Wave (SAW) Sensors: Physics, Materials, and Applications

Debdyuti Mandal et al.

Summary: This article introduces surface acoustic waves (SAWs) and their applications in sensors. By explaining the physics of guided SAWs and the piezoelectric materials used, it discusses how the materials and cuts can alter sensor functionality. It summarizes key electrode configurations and guidelines for generating different guided wave patterns, and explores the applications of SAW sensors in various fields and potential improvement plans in science and technology.

SENSORS (2022)

Add to Collection
Article Chemistry, Analytical

Integrated microfluidic system for efficient DNA extraction using on-disk magnetic stirrer micromixer

Amin Dehghan et al.

Summary: Micromixers are essential microfluidic modules for fabricating integrated lab-on-chip devices for point-of-care applications. In this study, a magnetic stirrer on a rotating micro-structured disk is presented to mix liquids of a wide range of viscosities in low rotational velocities. The on-disk magnetic stirrer can be implemented in integrated micmfluidic platforms without affecting other modules, and it is a convenient choice for the cell lysis process due to high mixing indexes and considerable viscous stresses.

SENSORS AND ACTUATORS B-CHEMICAL (2022)

Add to Collection
Article Chemistry, Analytical

AC electroosmosis micromixing on a lab-on-a-foil electric microfluidic device

Mengren Wu et al.

Summary: Efficient mixing of fluids is crucial for various biomedical and biochemical applications in lab-on-a-chip devices. This study explores electroosmosis micromixing in a lab-on-a-foil microfluidic device, achieving efficient micromixing using tooth-shaped planar electrodes. The study evaluates the mixing performance through intensity measurement and investigates the effects of frequency, flow rate, voltage amplitude, and number of electrode tooth pairs. The research demonstrates the potential for optimizing mixing performance in EOF-based micromixers and the fabrication of low-cost flexible electric microfluidic devices.

SENSORS AND ACTUATORS B-CHEMICAL (2022)

Add to Collection
Article Chemistry, Analytical

3D-printed low-cost fabrication and facile integration of flexible epidermal microfluidics platform

Lei Wei et al.

Summary: This study introduces an accessible, low-cost fabrication and integration scheme for flexible microfluidic architecture capable of reliable sweat collection and sensing. It utilizes low-cost 3D printing technology to create positive molds from easy-to-print materials for personalized customization of microfluidic channels. An innovative approach is proposed to encapsulate microfluidic channels and integrate pH sweat sensors, providing a cost-effective alternative to soft-lithography methods and reducing the threshold of microfluidic development and manufacture.

SENSORS AND ACTUATORS B-CHEMICAL (2022)

Add to Collection
Article Chemistry, Analytical

Microfluidic paper-based analytical device by using Pt nanoparticles as highly active peroxidase mimic for simultaneous detection of glucose and uric acid with use of a smartphone

Jie Zheng et al.

Summary: A simple microfluidic paper-based analytical device using platinum nanoparticles as peroxidase mimic was developed for simultaneous determination of glucose and uric acid. The multi-layered structure improves color uniformity and intensity, leading to enhanced sensitivity in detection. The device showed satisfactory results in real serum samples and integrated with smartphone for easy and intelligent detection, making it suitable for simple and portable on-site analysis.

TALANTA (2022)

Add to Collection
Review Engineering, Biomedical

Droplet-based microfluidics in biomedical applications

Leyla Amirifar et al.

Summary: Droplet-based microfluidic systems have become a significant tool in biomedical applications, allowing for manipulation of fluid volumes and enabling advancements in mixing, sorting, encapsulation, sensing, and high throughput device design. This review provides an overview of droplet generation methods, emulsification and particle synthesis approaches, and various biomedical applications. It also discusses the latest trends and future potentials in the field.

BIOFABRICATION (2022)

Add to Collection
Article Multidisciplinary Sciences

Microfluidic device engineered to study the trafficking of multiple myeloma cancer cells through the sinusoidal niche of bone marrow

Chao Sui et al.

Summary: This study reports a microfluidic device that mimics the bone marrow niche to study the interactions between multiple myeloma cells and the embedded microenvironment. The results suggest that the egression of multiple myeloma cells affects the structure and function of endothelial cells.

SCIENTIFIC REPORTS (2022)

Add to Collection
Article Engineering, Biomedical

Microfluidic Arrays of Breast Tumor Spheroids for Drug Screening and Personalized Cancer Therapies

Elisabeth Prince et al.

Summary: The study introduces a novel microfluidic platform for efficient studies on the effect of drug dose and supply rate on chemosensitivity of breast tumor spheroids, and demonstrates the capability to grow large arrays of tumor spheroids from patient-derived cells of different breast cancer subtypes.

ADVANCED HEALTHCARE MATERIALS (2022)

Add to Collection
Article Chemistry, Analytical

Digital Microfluidic qPCR Cartridge for SARS-CoV-2 Detection

Kuan-Lun Ho et al.

Summary: This study developed a disposable POC cartridge that detects the SARS-CoV-2 N gene with high accuracy and efficiency through digital microfluidics technology. The cartridge has multiple droplet tracks, allowing for multiple tests and controls at once.

MICROMACHINES (2022)

Add to Collection
Article Biotechnology & Applied Microbiology

Paper-based microfluidic chip for rapid detection of SARS-CoV-2 N protein

Mingdi Sun et al.

Summary: This study developed a method for rapid detection of SARS-CoV-2 N protein using a paper-based microfluidic chip. The method demonstrated high sensitivity and good repeatability, with the ability to detect N protein at a concentration as low as 8 μg/mL.

BIOENGINEERED (2022)

Add to Collection
Article Materials Science, Multidisciplinary

Antimicrobial hydrogel microspheres for protein capture and wound healing

Lanjie Lei et al.

Summary: Growth factors are essential for regulating cellular responses in wound healing, and a novel multifunctional chitosan microsphere has been developed for efficient growth factor delivery and wound repair. The microspheres exhibit antibacterial properties and have been shown to significantly promote wound healing in a rat model.

MATERIALS & DESIGN (2022)

Add to Collection
Review Pharmacology & Pharmacy

Recent Development of Drug Delivery Systems through Microfluidics: From Synthesis to Evaluation

Zhiyuan Ma et al.

Summary: Conventional drug administration often results in degradation and rapid excretion, leading to limited drug delivery to pathological sites. Drug delivery systems using microfluidic techniques offer precise control over drug synthesis, release, and observation, improving drug efficacy with minimal side effects. This review provides an overview of recent advances in nano drug delivery systems, carrier-free microfluidic systems, and in vitro models for evaluating drug delivery efficiency. Opportunities and challenges of microfluidic platforms in drug delivery systems are discussed, along with their clinical applications.

PHARMACEUTICS (2022)

Add to Collection
Article Nanoscience & Nanotechnology

Contributions of the microbiome to intestinal inflammation in a gut-on-a-chip

Min Seo Jeon et al.

Summary: This study presents a microfluidic-based gut model that can mimic the structure and function of the human intestine and enable co-culture of human and microbial cells. The gut-on-a-chip demonstrated the ability to recapitulate in vivo relevance epithelial cell differentiation and restore barrier function when co-cultured with probiotics, providing insights into the interaction between the intestinal microbiome and human health.

NANO CONVERGENCE (2022)

Add to Collection
Article Engineering, Biomedical

An overview of substrate stiffness guided cellular response and its applications in tissue regeneration

Bingcheng Yi et al.

Summary: Cell-matrix interactions and substrate stiffness play critical roles in tissue repair and regeneration. This review provides an overview of recent progress in understanding the cellular responses mediated by substrate stiffness and the manipulation of scaffold stiffness. It aims to facilitate interdisciplinary knowledge transfer and the design of suitable biomaterials for tissue regeneration.

BIOACTIVE MATERIALS (2022)

Add to Collection
Article Chemistry, Analytical

High-Aspect-Ratio Microfluidic Channel with Parallelogram Cross-Section for Monodisperse Droplet Generation

Hyeonyeong Ji et al.

Summary: In this study, a microfluidic device with a high-aspect-ratio (HAR) channel was developed for generating monodisperse droplets. The device was fabricated using simple and cheap MEMS processes and successfully obtained smaller monodisperse droplets for a wider range of flow rates compared to previous methods.

BIOSENSORS-BASEL (2022)

Add to Collection
Article Engineering, Biomedical

A metastasis-on-a-chip approach to explore the sympathetic modulation of breast cancer bone metastasis

Francisco Conceicao et al.

Summary: This study introduced a novel humanized organ-on-a-chip model recapitulating neuro-breast cancer crosstalk in a bone metastatic context. The research revealed that synergistic paracrine signaling from sympathetic neurons and osteoclasts increase breast cancer aggressiveness.

MATERIALS TODAY BIO (2022)

Add to Collection
Review Materials Science, Biomaterials

Human Organs-on-Chips: A Review of the State-of-the-Art, Current Prospects, and Future Challenges

Payam Zarrintaj et al.

Summary: Organ-on-a-chip (OOC) technology, utilizing miniaturized 3D organ models and microfluidics, has the potential to revolutionize cell biology studies, drug development processes, and cancer diagnosis/treatment by closely mimicking the structure and function of human organs, thus improving efficiency and reducing costs.

ADVANCED BIOLOGY (2022)

Add to Collection
Article Engineering, Biomedical

Microfluidic one-directional interstitial flow generation from cancer to cancer associated fibroblast

Jaehoon Kim et al.

Summary: Tumors create interstitial flow (IF), which allows soluble substances from cancer cells to be transported towards the tumor stroma. Researchers have designed a microfluidic device that mimics one-directional flow of IF to investigate how cancer cells activate and differentiate stromal cells.

ACTA BIOMATERIALIA (2022)

Add to Collection
Article Chemistry, Analytical

Lys-AuNPs@MoS2 Nanocomposite Self-Assembled Microfluidic Immunoassay Biochip for Ultrasensitive Detection of Multiplex Biomarkers for Cardiovascular Diseases

Jiaoyan Qiu et al.

Summary: In this study, a novel nanocomposite self-assembled microfluidic immunoassay biochip was developed for simultaneous detection of multiple serum biomarkers. The biochip showed high throughput and sensitivity, providing a promising method for clinical diagnosis of cardiovascular diseases.

ANALYTICAL CHEMISTRY (2022)

Add to Collection
Article Chemistry, Analytical

In Situ Microreaction Platform Based on Acoustic Droplet Manipulation for Ultra-High-Precision Multiplex Bioassay

Yu Xia et al.

Summary: This paper presents an acoustic droplet system for rapid and efficient biological detection and chemical screening. The system utilizes acoustic wave devices to achieve rapid and nondestructive mixing of droplets and increase the detection limit. By employing color reaction and coordinated detection of photodiodes, a biomarker detection protocol with short reaction time and high accuracy is developed.

ANALYTICAL CHEMISTRY (2022)

Add to Collection
Article Biophysics

Direct capture and smartphone quantification of airborne SARS-CoV-2 on a paper microfluidic chip

Sangsik Kim et al.

Summary: This study demonstrates a method for direct capture of airborne droplets on a paper microfluidic chip without the need for additional equipment. By adding antibody-conjugated submicron particle suspension and using a smartphone-based fluorescence microscope, the capture-to-assay time was less than 30 minutes. This approach allows for the direct detection of SARS-CoV-2 in a handheld and low-cost manner, contributing to slowing its spread.

BIOSENSORS & BIOELECTRONICS (2022)

Add to Collection
Review Chemistry, Inorganic & Nuclear

Recent advances in enzyme immobilization based on novel porous framework materials and its applications in biosensing

Yanmei Feng et al.

Summary: This paper discusses the challenges of enzyme immobilization in nano-space and explores the potential of metal-organic frameworks, covalent organic frameworks, and hydrogen-bonded organic frameworks as promising carriers for enzyme immobilization. Additionally, the paper provides a comprehensive summary of the applications of enzyme-MOF/COF/HOF biocomposites in various sensing strategies and tentatively discusses the challenges and opportunities in this field.

COORDINATION CHEMISTRY REVIEWS (2022)

Add to Collection
Article Materials Science, Multidisciplinary

Numerical and experimental investigation of a magnetic micromixer under microwires and uniform magnetic field

Jiajia Sun et al.

Summary: With the development in biomedical and biotechnological areas, microfluidic devices with efficient mixing function have been attracting attention. In this study, a magnetic micromixer was designed and fabricated to achieve rapid mixing between ferrofluid and deionized water. Experimental and numerical analysis showed that the introduction of microwires and a uniform magnetic field enhanced the mixing efficiency.

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS (2022)

Add to Collection
Article Engineering, Electrical & Electronic

Fabrication and flow rate characterization of a DRIE process based valveless piezoelectric micropump

Sevda Simsek et al.

Summary: This study designs and fabricates a piezoelectric micropump using dry etching and DRIE technology, eliminating leakage and air entrapment. The micropump doesn't require moving mechanical valves, minimizing the risks of clogging and reduced reliability. It achieves a high flow rate with a low excitation voltage.

JOURNAL OF MICROMECHANICS AND MICROENGINEERING (2022)

Add to Collection
Article Chemistry, Multidisciplinary

Trapping of Aqueous Droplets under Surface Acoustic Wave-Driven Streaming in Oil-Filled Microwells

A. Nath et al.

Summary: In this study, we investigate the trapping of aqueous droplets in oil-filled microwells using surface acoustic waves. We find that the combined effect of acoustic radiation and hydrodynamic forces leads to droplet migration and trapping, and we elucidate the mechanism of these forces using a theoretical model.

LANGMUIR (2022)

Add to Collection
Article Chemistry, Analytical

Design and fabrication of an integrated 3D dynamic multicellular liver-on-a-chip and its application in hepatotoxicity screening

Yi-bo Zheng et al.

Summary: A three-dimensional dynamic multi-cellular liver-on-a-chip device was developed to mimic the microenvironment of in vivo liver tissue, showing improved liver function and drug toxicity detection capabilities compared to traditional static cultures, by co-culturing hepatocytes and endothelial cells in the chip.

TALANTA (2022)

Add to Collection
Article Multidisciplinary Sciences

Development of a one-step analysis method for several amino acids using a microfluidic paper-based analytical device

Akimitsu Kugimiya et al.

Summary: A one-step analysis method using a microfluidic paper-based analytical device was developed for detecting four types of amino acids. The method is simple, easy, and allows for simultaneous detection of multiple amino acid concentrations.

SCIENTIFIC REPORTS (2022)

Add to Collection
Article Engineering, Biomedical

3D-Printed Centrifugal Pump Driven by Magnetic Force in Applications for Microfluidics in Biological Analysis

Byeongwook Jo et al.

Summary: This study presents a 3D-printed centrifugal pump driven by magnetic force for microfluidics and biological analysis. The pump has a compact size and contactless driving part, making it suitable for conventional experimental setups. It is demonstrated that this device has a high potential for applications in microfluidic devices and perfusion culture of cells.

ADVANCED HEALTHCARE MATERIALS (2022)

Add to Collection
Article Chemistry, Analytical

High-Resolution Separation of Nanoparticles Using a Negative Magnetophoretic Microfluidic System

Lin Zeng et al.

Summary: In this study, a microfluidic system based on negative magnetophoresis is proposed for the high-resolution separation of nanoparticles. The system can purify 200 nm particles with high purity and recovery rate. Compared with existing methods, the system shows significant improvements in particle size resolution and sample processing throughput.

MICROMACHINES (2022)

Add to Collection
Article Chemistry, Analytical

Microfluidic Organ-on-a-Chip Devices for Liver Disease Modeling In Vitro

Perizat Kanabekova et al.

Summary: Mortality from liver disease is high and prompt measures are crucial. Microfluidic organs-on-chip platforms offer potential for studying the pathophysiology of liver diseases in vitro and evaluating drug efficacy. This review provides a comprehensive overview of liver disease modeling using microphysiological platforms, including cell signaling pathways, cell culture techniques, disease types, and design challenges with existing solutions.

MICROMACHINES (2022)

Add to Collection
Review Chemistry, Analytical

Conventional and Microfluidic Methods for the Detection of Nucleic Acid of SARS-CoV-2

Weidu Song et al.

Summary: This paper introduces the crucial role of nucleic acid testing (NAT) in containing the spread of SARS-CoV-2 and provides a comprehensive review and comparison of various detection technologies, including traditional techniques and microfluidic-based technologies, discussing their characteristics and development prospects.

MICROMACHINES (2022)

Add to Collection
Article Chemistry, Analytical

Artificial Intelligence Algorithms Enable Automated Characterization of the Positive and Negative Dielectrophoretic Ranges of Applied Frequency

Matthew Michaels et al.

Summary: This study describes a phenomenological approach to automatically determine the frequency range for positive and negative dielectrophoresis (DEP) in order to achieve massive micro- and nano-assembly. Through experiments and AI algorithms, the frequency thresholds for positive and negative DEP are determined, and the experimental results are consistent with previous research findings.

MICROMACHINES (2022)

Add to Collection
Review Chemistry, Multidisciplinary

Microfluidic Particle Reactors: From Interface Characteristics to Cells and Drugs Related Biomedical Applications

Xin Hao et al.

Summary: Functional microfluidic particle reactors (MPRs) are a method to encapsulate bioactive substances in microfluidic emulsions for various biomedical applications. The particle structure and interface characteristics of MPRs are determined by optimizing emulsion template fluid components and interfacial complexity. Functional biomaterials can further expand the interface characteristics of MPRs and improve their effectiveness in cell and drug-related applications. However, there are still challenges in improving the unique interface characteristics of MPRs for broader biomedical applications.

ADVANCED MATERIALS INTERFACES (2022)

Add to Collection
Article Chemistry, Multidisciplinary

Study on Filling Capacity of Optical Glass in a Novel Rapid Hot Embossing Process

Jianzhi Li et al.

Summary: This paper presents a novel rapid hot embossing approach and investigates the filling capacity of optical glass in the hot embossing process. The experimental results indicate that the embossing force and embossing temperature have a more significant influence on the filling capacity of N-BK7 glass.

APPLIED SCIENCES-BASEL (2022)

Add to Collection
Article Chemistry, Multidisciplinary

CuO Nanozymes as Multifunctional Signal Labels for Efficiently Quenching the Photocurrent of ZnO/Au/AgSbS2 Hybrids and Initiating a Strong Fluorescent Signal in a Dual-Mode Microfluidic Sensing Platform

Tingting Wu et al.

Summary: A novel dual-mode microfluidic sensing platform based on CuO nanozymes as a photoelectrochemical (PEC)-fluorescent (FL) multifunctional signal label was developed for ultrasensitive neuron specific enolase (NSE) detection. The platform utilized ZnO/Au/AgSbS2 hybrids as a sensing matrix to provide a stable photocurrent, and the controlled synthesis of photoactive ZnO nanoflowers (NFs) was successfully conducted using a microfluidic reactor. CuO nanozymes were employed to catalytically oxidize ascorbic acid (AA) and quench the PEC signals, while initiating FL signals through reaction with o-phenylenediamine. The platform exhibited wide linear ranges and low detection limits for both PEC and FL techniques, enabling sensitive detection of NSE.

ACS SENSORS (2022)

Add to Collection
Article Nanoscience & Nanotechnology

Acoustofluidics for simultaneous nanoparticle-based drug loading and exosome encapsulation

Zeyu Wang et al.

Summary: Researchers have developed an acoustofluidic device that enables simultaneous drug loading and exosome encapsulation. This device utilizes acoustic forces to concentrate and fuse drugs and nanoparticles, resulting in drug-loaded silica nanocarriers encased within an exosomal membrane. The drug loading efficiency is significantly improved, and the process can be completed within minutes, without the need for complex chemical modification.

MICROSYSTEMS & NANOENGINEERING (2022)

Add to Collection
Article Nanoscience & Nanotechnology

Patient-derived pancreatic cancer-on-a-chip recapitulates the tumor microenvironment

Muhammad R. Haque et al.

Summary: Pancreatic ductal adenocarcinoma (PDAC) is highly heterogeneous, which hampers treatment and clinical trials. Patient-derived organoids (PDOs) have opened the door for personalized medicine. This study developed a tumor-chip device that replicates the PDAC tumor microenvironment and validated its application in drug testing.

MICROSYSTEMS & NANOENGINEERING (2022)

Add to Collection
Article Chemistry, Analytical

Microfluidics-Based Biosensing Platforms: Emerging Frontiers in Point-of-Care Testing SARS-CoV-2 and Seroprevalence

Elda A. Flores-Contreras et al.

Summary: This article discusses the application of microfluidic technology in the detection of SARS-CoV-2 and seroprevalence, and describes commercially available alternatives based on microfluidic platforms. Timely and accurate results are crucial for healthcare professionals to provide efficient treatments and make appropriate decisions.

BIOSENSORS-BASEL (2022)

Add to Collection
Review Chemistry, Analytical

3D Printing in Solid Dosage Forms and Organ-on-Chip Applications

Tarek Kassem et al.

Summary: 3D printing technology can be used for personalized dosing pharmaceuticals as well as creating 3D models for drug screening, sensing, testing, and organ-on-chip applications. Efforts are being made to improve the limitations of this technology, such as restricted excipient choices, time constraints, industrial production limitations, and overall costs. This review provides an overview of the 3D printing process, types of materials used, and the pros and cons of different techniques in creating solid dosage forms and producing 3D models for sensing, testing, and screening substances.

BIOSENSORS-BASEL (2022)

Add to Collection
Article Chemistry, Analytical

Portable Waveguide-Based Optical Biosensor

Philip A. Kocheril et al.

Summary: Rapid on-site diagnostics are crucial for timely intervention and response in warfare, environmental monitoring, and global health. Portable optical biosensors are being extensively researched as a means of achieving fast and accurate fieldable biosensing. The portable engineered analytic sensor with automated sampling (PEGASUS) has been developed as a fieldable, generalizable biosensing platform.

BIOSENSORS-BASEL (2022)

Add to Collection
Review Biology

Microfluidics Technology in SARS-CoV-2 Diagnosis and Beyond: A Systematic Review

Mohd. Raeed Jamiruddin et al.

Summary: This review explores the application of microfluidic technologies in COVID-19 pandemic, particularly their combination with different detection techniques for rapid and sensitive detection of virus antibodies, antigens, and nucleic acids. The study found that polymers like PDMS and PMMA are commonly used materials for microfluidic devices, with centrifugal force being the most widely used fluid manipulation technique. Different types of detection techniques were employed depending on the target, such as spectrometer-based detection for antibody detection and electrochemical-based detection for antigen detection. Sensitivity and specificity of the devices were found to vary with the combination of detection-based technique and fluid manipulation technique. Most microfluidic devices are simple and can be easily deployed in various environments, playing a significant role in improving infection detection rate and healthcare services.

LIFE-BASEL (2022)

Add to Collection
Article Engineering, Biomedical

Fusing spheroids to aligned μ-tissues in a heart-on-chip featuring oxygen sensing and electrical pacing capabilities

Oliver Schneider et al.

Summary: Over the past decade, Organ-on-Chip (OoC) has emerged as a promising technology for advanced in vitro models that mimic key physiological cues. A novel concept using spheroids derived from induced pluripotent stem cells is presented for cell injection and tissue generation, allowing for large-scale production of uniform-sized spheroids. These spheroids are then transported and accumulated in dogbone-shaped tissue chambers, where they fuse and form aligned, contracting cardiac muscle fibers. The study also demonstrates electrical stimulation capabilities using fluidic media connectors as electrodes and incorporates optical O2 sensor spots into resin-based microfluidic systems for in situ determination of O2 partial pressures. Overall, this system provides a blueprint for integrating biophysical stimulation and probing capabilities in advanced Organ-on-Chip technology, facilitating the facile and robust generation of high-density microtissues that can be scaled-up and automated.

MATERIALS TODAY BIO (2022)

Add to Collection
Article Biophysics

Smartphone paired SIM card-type integrated creatinine biosensor

Eleni Tzianni et al.

Summary: The medical diagnostic sector is in need of affordable, handheld devices for clinical analysis. In this study, a SIM card-type pH responsive polymer-modified paper-based biosensing device was proposed for the determination of urinary creatinine. The device features a microfluidic channel on a paper strip and selective analysis through polymer modification, coupled with wireless communication support. The device was successfully applied for the determination of urinary creatinine.

BIOSENSORS & BIOELECTRONICS (2022)

Add to Collection
Article Biophysics

Smartphone-based sensitive detection of SARS-CoV-2 from saline gargle samples via flow profile analysis on a paper microfluidic chip

Patarajarin Akarapipad et al.

Summary: In this study, rapid and sensitive detection of SARS-CoV-2 from saliva samples was demonstrated. The assay was made user-friendly by using a smartphone, an antibody-conjugated particle suspension, and a paper microfluidic chip. The unique flow profile analysis method showed high specificity and short assay time.

BIOSENSORS & BIOELECTRONICS (2022)

Add to Collection
Article Biophysics

Electrochemical/visual microfluidic detection with a covalent organic framework supported platinum nanozyme-based device for early diagnosis of pheochromocytoma

Xiaoya Liu et al.

Summary: In this study, a dual-mode (electrochemical/visual) microfluidic device was developed for the rapid and sensitive detection of circulating tumor cells (CTCs) in pheochromocytoma (PCC). The device utilized specific immunogenic binding and nanozymes for capture, separation, and quantification of PCC-CTCs. The device demonstrated a low detection limit and a wide linear range, making it a portable and reliable platform for point-of-care diagnostics.

BIOSENSORS & BIOELECTRONICS (2022)

Add to Collection
Article Multidisciplinary Sciences

A microengineered Brain-Chip to mode neuroinflammation in humans

Iosif Pediaditakis et al.

Summary: Species differences in brain and blood-brain barrier biology hinder the translation of research findings from animal models to humans. In this study, a human organotypic microphysiological system (MPS) that mimics critical aspects of neuroinflammation was developed and showed significant improvements in clinical mimicry compared to previous MPS models. Transcriptomic profiling demonstrated advanced similarity to the human adult cortex and enrichment in key neurobiological pathways. This robust brain MPS provides a platform for studying cell-cell interactions and blood-brain barrier function during neuroinflammation.

ISCIENCE (2022)

Add to Collection
Article Chemistry, Multidisciplinary

Effect of shear stress on the proximal tubule-on-a-chip for multi-organ microphysiological system

Hyoungseob Kim et al.

Summary: This study focused on evaluating the excretion function of renal proximal tubular epithelial cells (RPTECs) using a multi-organ-on-a-chip (MOC) platform. By varying shear stresses, the researchers simulated different conditions of renal tubular function. The results demonstrated that the reabsorption and excretion of RPTECs could be adjusted by shear stress and effectively reproduced.

JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY (2022)

Add to Collection
Article Chemistry, Analytical

Surface acoustic wave immunosensor based on Au-nanoparticles-decorated graphene fluidic channel for CA125 detection

Chenxi Zhao et al.

Summary: A delay line configuration Rayleigh SAW immunosensor with an Au-nanoparticles-decorated graphene fluidic channel is proposed for the detection of CA125. The sensor exhibits a wider linear response range, lower detection limit, good specificity, and long-term stability.

SENSORS AND ACTUATORS B-CHEMICAL (2022)

Add to Collection
Article Multidisciplinary Sciences

A guide to the organ-on-a-chip

Chak Ming Leung et al.

Summary: This article introduces the basic concepts, applications, and development trends of organ-on-chip (OoC) technology, as well as factors to consider when developing application-specific OoCs.

NATURE REVIEWS METHODS PRIMERS (2022)

Add to Collection
Article Nanoscience & Nanotechnology

Manipulations of micro/nanoparticles using gigahertz acoustic streaming tweezers

Hang Wu et al.

Summary: This study investigates the behavior of micro/nanoscale particles trapped in gigahertz acoustic streaming tweezers (AST) through theoretical analyses, 3D simulations, and microparticle tracking experiments. The particle motion in the vortices is found to be mainly influenced by the balance between the acoustic streaming drag force and the acoustic radiation force. This work provides fundamental design principles for AST-based lab-on-a-chip systems for various applications.

NANOTECHNOLOGY AND PRECISION ENGINEERING (2022)

Add to Collection
Article Engineering, Biomedical

Properties and Applications of PDMS for Biomedical Engineering: A Review

Ines Miranda et al.

Summary: This review provides an overview of the properties of PDMS and its applications in the field of micro and nanoengineering. PDMS is widely used in biomedical applications due to its excellent optical, electrical, and mechanical properties, as well as biocompatibility. The introduction of the soft-lithography technique has facilitated the rapid prototyping of micro and nanostructures using PDMS, leading to advances in microfluidics, electronics, and biomedicine.

JOURNAL OF FUNCTIONAL BIOMATERIALS (2022)

Add to Collection
Article Physics, Fluids & Plasmas

Acoustic particle trapping driven by axial primary radiation force in shaped traps

L. Malik et al.

Summary: This study investigates particle trapping in shaped traps driven by the axial primary radiation force. The competition between the axial primary radiation force and viscous drag force determines particle trajectory. A general criterion based on the ratio of acoustic energy to viscous work is proposed for particle trapping at a specific location.

PHYSICAL REVIEW E (2022)

Add to Collection
Review Materials Science, Multidisciplinary

Biomaterials for microfluidic technology

Zehao Chen et al.

Summary: Micro/nanomaterial-based drug and cell delivery systems have great potentials in biomedical fields due to their injectability and targeting ability. Microfluidics technology, with its flexible design of channels and manipulation of fluid behavior, has become a powerful tool for producing biomaterial micro/nanocarriers with precise structural control and high reproducibility. This review summarizes recent advances in biomaterials used for functional microfluidic vehicles and discusses the limitations and future perspectives of microfluidic biomaterial carriers.

MATERIALS FUTURES (2022)

Add to Collection
Review Biochemical Research Methods

A review of dielectrophoretic separation and classification of non-biological particles

Georg R. Pesch et al.

Summary: Dielectrophoresis (DEP) is a selective electrokinetic particle manipulation technology with applications in biomedical research using microfluidic devices. This paper reviews high-throughput DEP separators and research on separation and analysis of non-biological particle systems.

ELECTROPHORESIS (2021)

Add to Collection
Article Materials Science, Ceramics

A novel and flexible processing for hot embossing of glass microfluidic channels

Kai Jiang et al.

Summary: This study proposes a new method for hot embossing of glass microfluidic channels, using a high-T-g glass mold insert to create flexible and reliable channels. Experimental results demonstrate that the high-T-g glass has good surface quality and high-temperature resistance, making it a suitable material for hot embossing mold inserts.

CERAMICS INTERNATIONAL (2021)

Add to Collection
Article Chemistry, Analytical

Two-Step Acoustophoresis Separation of Live Tumor Cells from Whole Blood

Eva Undvall Anand et al.

Summary: The study presents a novel two-step acoustophoresis method for isolating unfixed, viable cancer cells from whole blood, enabling functional analysis and in vitro culture. The method demonstrated extensive elimination of white blood cells while recovering viable cancer cells for downstream applications.

ANALYTICAL CHEMISTRY (2021)

Add to Collection
Article Chemistry, Multidisciplinary

Two-Photon Polymerization of Nanocomposites for the Fabrication of Transparent Fused Silica Glass Microstructures

Frederik Kotz et al.

Summary: Fused silica glass is an ideal material for high-performance optics, and direct laser writing (DLW) can be used to generate transparent fused silica glass microstructures with resolutions on the scale of tens of micrometers. This technology has the potential to enable a wide range of applications in next-generation optics and photonics, as well as microfluidics and biomedical fields.

ADVANCED MATERIALS (2021)

Add to Collection
Article Engineering, Biomedical

A multi-niche microvascularized human bone marrow (hBM) on-a-chip elucidates key roles of the endosteal niche in hBM physiology

Michael R. Nelson et al.

Summary: The study presents a unique microfluidic hBM-on-a-chip that accurately mimics the human bone marrow microenvironment, providing new opportunities for research and intervention in bone marrow diseases. The complex structure of the chip increases experimental efficiency and reproducibility, while offering insights into the dynamics of hematopoietic stem cells.

BIOMATERIALS (2021)

Add to Collection
Article Biophysics

Cryopreservation of a cell-based biosensor chip modified with elastic polymer fibers enabling ready-to-use on-site applications

Dua Ozsoylu et al.

Summary: The proposed on-sensor cryopreservation strategy allows for freezing adherent cells directly on a biosensor surface, improving cell recovery and viability. Integration of electrospun fibers and O-2 plasma treatment on a modified sensor provides a controlled micro-environment for fast thawing and cell preservation. This novel cryo-chip system enables label-free and quantitative measurements directly after thawing, eliminating the need for post-thaw culturing steps and opening up new possibilities for ready-to-use on-site systems.

BIOSENSORS & BIOELECTRONICS (2021)

Add to Collection
Review Biotechnology & Applied Microbiology

Engineering precision nanoparticles for drug delivery

Michael J. Mitchell et al.

Summary: The development of nanoparticles has shown promising clinical applications, overcoming the limitations of therapeutic interventions and biological barriers. Precision therapies have enhanced treatment efficacy through personalized interventions. Advancements in nanoparticle design aim to optimize drug delivery, improving efficacy in general applications and enabling tailored designs for precision applications.

NATURE REVIEWS DRUG DISCOVERY (2021)

Add to Collection
Article Multidisciplinary Sciences

SARS-CoV-2 induced intestinal responses with a biomimetic human gut-on-chip

Yaqiong Guo et al.

Summary: The research team developed an intestinal infection model on a chip that recapitulates the pathophysiology induced by SARS-CoV-2 at the organ level, providing insights into the intestinal barrier injury caused by viral infection. The model reconstructs key features of the intestinal epithelium-vascular endothelium barrier through 3D co-culture, offering a unique and rapid platform for COVID-19 research.

SCIENCE BULLETIN (2021)

Add to Collection
Article Engineering, Biomedical

Fabrication of a hydroxyapatite-PDMS microfluidic chip for bone-related cell culture and drug screening

Qiangqiang Tang et al.

Summary: In this study, a microfluidic chip using HA as a component was developed to create a highly bionic bone environment, which was found to be more conducive to cell proliferation and osteogenic differentiation compared to PDMS. The chip successfully generated a concentration gradient of model drug and determined the drug's IC50, showing great potential in high-throughput bone-related drug screening and research.

BIOACTIVE MATERIALS (2021)

Add to Collection
Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Add to Collection
Article Electrochemistry

Continuous sweat lactate monitoring system with integrated screen-printed Mgo-templated carbon-lactate oxidase biosensor and microfluidic sweat collector

Isao Shitanda et al.

Summary: This study developed a lightweight and comfortable lactate sensing system for the continuous monitoring of sweat lactate, enabling the detection of lactate threshold and suitable for the training and exertion control of athletes, rehabilitation patients, elderly individuals, and high-performance workers.

ELECTROCHIMICA ACTA (2021)

Add to Collection
Article Materials Science, Biomaterials

Polyanion-induced, microfluidic engineering of fragmented collagen microfibers for reconstituting extracellular environments of 3D hepatocyte culture

Rie Utoh et al.

Summary: A unique process was proposed in this study to fabricate fragmented collagen microfibers using a microfluidic laminar-flow system, which can reconstitute the 3D microenvironments surrounding hepatocytes by controlling the morphology. The fragmented fibers enhanced the survival and functions of hepatocytes, promoting the formation of cell-cell and cell-matrix interactions.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

Add to Collection
Article Materials Science, Biomaterials

Microfluidic-templating alginate microgels crosslinked by different metal ions as engineered microenvironment to regulate stem cell behavior for osteogenesis

Yujie Zhang et al.

Summary: The study demonstrates that metal ions play a critical role in influencing cell behavior and affecting the efficacy of stem cell-based therapy in tissue regeneration, providing new insights into engineering specific microenvironments for regenerative medicine.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

Add to Collection
Review Biochemistry & Molecular Biology

Fabrication and Applications of Microfluidic Devices: A Review

Adelina-Gabriela Niculescu et al.

Summary: Microfluidics is an emerging field that combines principles from various disciplines to fabricate miniaturized chips with channels and chambers. These chips, made using diverse methods, can be utilized in nanoparticle preparation, cell analysis, and diagnosis, among other biomedical applications.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Add to Collection
Article Biophysics

Microfluidic detection of human diseases: From liquid biopsy to COVID-19 diagnosis

Kuan Jiang et al.

Summary: Microfluidic devices offer an integrated approach for handling multiple experimental tasks, effectively addressing health challenges and improving the performance of disease diagnostic technologies.

JOURNAL OF BIOMECHANICS (2021)

Add to Collection
Article Pathology

Microchip RT-PCR Detection of Nasopharyngeal SARS-CoV-2 Samples

Razvan Cojocaru et al.

Summary: The study introduces a rapid and accurate microchip real-time PCR assay for detecting SARS-CoV-2, reducing reagent usage by 10-fold compared to tube-based methods. Validation with contrived samples and clinical specimens demonstrated the method's comparable sensitivity and specificity, offering a resource-saving alternative for COVID-19 testing.

JOURNAL OF MOLECULAR DIAGNOSTICS (2021)

Add to Collection
Article Chemistry, Analytical

Continuous optical sorting of nanoscale biomolecules in integrated microfluidic-nanophotonic chips

Haitao Zhao et al.

Summary: The SWANS platform utilizes microfluidic-nanophotonic technology to achieve continuous sorting of nanoscale biomolecules. Through the study of near-field optical lattice and sorting mechanism, efficient separation of mixtures is achieved.

SENSORS AND ACTUATORS B-CHEMICAL (2021)

Add to Collection
Article Engineering, Biomedical

A novel tumor-immune microenvironment (TIME)-on-Chip mimics three dimensional neutrophil-tumor dynamics and neutrophil extracellular traps (NETs)-mediated collective tumor invasion

Vikram Surendran et al.

Summary: Neutrophils play dual roles in tumors, with the potential to both promote and limit tumor growth. Studying the interaction between neutrophils and tumor cells can provide insights into tumor progression. In this study, a novel microfluidic device was used to demonstrate that neutrophils respond to growing tumor spheroids by forming neutrophil extracellular traps (NETs), which stimulate tumor cells to collectively invade the surrounding matrix. This location-dictated mechanism of NETosis suggests a new avenue for anti-tumor therapeutics research.

BIOFABRICATION (2021)

Add to Collection
Review Nanoscience & Nanotechnology

Microfluidics in cardiovascular disease research: state of the art and future outlook

Qingming Ma et al.

Summary: Microfluidics has been extensively used as a versatile strategy for achieving a comprehensive understanding of cardiovascular diseases, including investigating pathogenetic mechanisms, developing accurate diagnostic methods, and establishing therapeutic treatments.

MICROSYSTEMS & NANOENGINEERING (2021)

Add to Collection
Article Biology

Second-generation lung-on-a-chip with an array of stretchable alveoli made with a biological membrane

Pauline Zamprogno et al.

Summary: A new generation lung-on-a-chip utilizing a biological membrane made of collagen and elastin has been developed to mimic an array of tiny alveoli with in vivo-like dimensions. This membrane outperforms traditional PDMS in terms of stability, biodegradability, and tunability, offering the potential to more accurately reproduce air-blood barrier functions.

COMMUNICATIONS BIOLOGY (2021)

Add to Collection
Article Engineering, Biomedical

Droplet microfluidics as a tool for production of bioactive calcium phosphate microparticles with controllable physicochemical properties

Victor P. Galvan-Chacon et al.

Summary: Affordable and effective biomaterials are needed for successful treatment of orthopaedic bone defects. Calcium phosphate ceramics are commonly used for bone repair, but further optimization is necessary. A microfluidic strategy for producing CaP microparticles with controlled properties was developed in this study, showing potential for bioactive ceramics synthesis.

ACTA BIOMATERIALIA (2021)

Add to Collection
Article Biochemical Research Methods

Toward embryo cryopreservation-on-a-chip: A standalone microfluidic platform for gradual loading of cryoprotectants to minimize cryoinjuries

Pouria Tirgar et al.

Summary: The study introduces a standalone microfluidic system to automate the process of embryo vitrification, minimizing osmotic shock and reducing the molecular impact. Comparing the device to conventional manual procedures, it shows comparable re-expansion and hatching rates in vitrified-warmed mouse blastocysts, with on-chip loading reducing detrimental gene expression related to cryopreservation.

BIOMICROFLUIDICS (2021)

Add to Collection
Article Biophysics

Design and fabrication of an integrated heart-on-a-chip platform for construction of cardiac tissue from human iPSC-derived cardiomyocytes and in situ evaluation of physiological function

Feng Zhang et al.

Summary: In vitro model of human cardiac tissues generated from human induced pluripotent stem cells (hiPSCs) is useful for drug discovery and personalized studies of physiology and disease. A heart-on-a-chip device was developed, enabling long-term dynamic culture and electrical stimulation of hiPSC-CMs for drug testing, showing promising reliability.

BIOSENSORS & BIOELECTRONICS (2021)

Add to Collection
News Item Optics

Force measurement goes to femto-Newton sensitivity of single microscopic particle

Xiaohe Zhang et al.

Summary: Researchers have proposed a new method that can measure the weak force of a single microscopic particle.

LIGHT-SCIENCE & APPLICATIONS (2021)

Add to Collection
Review Chemistry, Analytical

Microfluidic Systems for Cancer Diagnosis and Applications

Semra Akgonullu et al.

Summary: Microfluidic devices have enabled novel biological advancements by mimicking and measuring micro systems, particularly in cancer diagnostics and management.

MICROMACHINES (2021)

Add to Collection
Article Chemistry, Analytical

Fused Deposition Modeling of Microfluidic Chips in Transparent Polystyrene

Markus Mader et al.

Summary: Polystyrene (PS) is widely used in biomedical and life science research, and this study presents a novel approach of 3D printing transparent PS microfluidic chips. The successful development of this prototyping method using fused deposition modeling (FDM) will significantly accelerate the production of future biomedical microfluidic chips.

MICROMACHINES (2021)

Add to Collection
Article Engineering, Chemical

The effects of baffle configuration and number on inertial mixing in a curved serpentine micromixer: Experimental and numerical study

Vahid Ebrahimpour Ahmadi et al.

Summary: This study introduces baffles into curved serpentine micromixers to improve mixing performance at low Reynolds numbers. Experimental and numerical results show that the chaotic advection generated by baffles plays a major role in enhancing mixing efficiency.

CHEMICAL ENGINEERING RESEARCH & DESIGN (2021)

Add to Collection
Article Chemistry, Multidisciplinary

Point-of-Care Testing for Multiple Cardiac Markers Based on a Snail-Shaped Microfluidic Chip

Binfeng Yin et al.

Summary: The study presents a snail-shaped microfluidic chip (SMC) for multiplex detection of cardiac markers with high sensitivity and short detection time. The SMC, consisting of a sandwich structure, can detect cTnI, CK-MB, and Myo at low concentrations, making it a promising platform for simultaneous determination of multianalytes with potential application in POCT.

FRONTIERS IN CHEMISTRY (2021)

Add to Collection
Article Engineering, Multidisciplinary

Effects of Three-Dimensional Platform Stiffness and Layer Dimensions on Separation of Carcinoma Cells

W. G. Zhang et al.

Summary: Engineered 3D biomimetic scaffold platforms were developed to successfully separate nasopharyngeal carcinoma cells from immortalized nasopharyngeal epithelial cells based on their unique migration behavior. By precisely controlling design parameters and adding an active conditioned medium, the separation efficiency was significantly improved, demonstrating the potential for cancer diagnosis and treatment using biomimetic engineered platforms.

ENGINEERING (2021)

Add to Collection
Article Nanoscience & Nanotechnology

Effect of biochemical and biomechanical factors on vascularization of kidney organoid-on-a-chip

Han Na Lee et al.

Summary: By mimicking shear stress fluid flow and optimizing extracellular matrix conditions, our kidney organoid-on-a-chip system showed more mature podocytes and vascular structures compared to static culture, with increased sensitivity to nephrotoxic drugs. Physiological flow was demonstrated to play a crucial role in maintaining various physiological functions of kidney organoids.

NANO CONVERGENCE (2021)

Add to Collection
Review Chemistry, Multidisciplinary

Advances in oxidase-mimicking nanozymes: Classification, activity regulation and biomedical applications

Yu Chong et al.

Summary: This article introduces the classification, catalytic mechanisms, and methods for regulating the activity of oxidase-mimicking nanozymes, discusses their potential applications in the biomedical field, and also points out the research opportunities and challenges in this area.

NANO TODAY (2021)

Add to Collection
Article Multidisciplinary Sciences

Versatile and flexible microfluidic qPCR test for high-throughput SARS-CoV-2 and cellular response detection in nasopharyngeal swab samples

Julien Fassy et al.

Summary: The emergence and fast spread of SARS-CoV-2 has highlighted the insufficient testing capacity in many countries due to limitations in resources, technology, and personnel. While traditional RT-qPCR diagnostic tests remain the standard method, a quantitative nanofluidic assay based on the Biomark™ instrument from Fluidigm offers a more efficient and cost-effective approach to testing, overcoming some of the limitations of traditional methods. This advanced system allows for high-throughput testing, monitoring of specific SARS-CoV-2 variants, and detection of other pathogens and host cellular responses.

PLOS ONE (2021)

Add to Collection
Review Chemistry, Analytical

Addressing the Selectivity of Enzyme Biosensors: Solutions and Perspectives

Bogdan Bucur et al.

Summary: Enzymatic biosensors have achieved commercial success and continued research is focused on expanding their practical applications; addressing selectivity challenges is crucial for these biosensors to reach their full potential. In addition to traditional solutions like permselective membranes and multi-enzyme systems, recent ingenious approaches involving nanomaterials have emerged to ensure biosensor selectivity.

SENSORS (2021)

Add to Collection
Article Multidisciplinary Sciences

High throughput viscoelastic particle focusing and separation in spiral microchannels

Tharagan Kumar et al.

Summary: In this study, high Reynolds number viscoelastic particle focusing and separation in spiral channels was explored. The balance between dominant inertial lift force, dean drag force, and elastic force enables stable 3D particle focusing at dynamically high Reynolds numbers. Effective separation based on size was achieved with high precision.

SCIENTIFIC REPORTS (2021)

Add to Collection
Article Multidisciplinary Sciences

A simple, low cost and reusable microfluidic gradient strategy and its application in modeling cancer invasion

Mohamadmahdi Samandari et al.

Summary: This study introduces a simple strategy for preparing a reusable microfluidic gradient generator to study cellular behavior. By directly mounting PDMS on commercial cell culture surfaces, the complexity of microfluidic assays is reduced and a reusable PDMS microchip is provided.

SCIENTIFIC REPORTS (2021)

Add to Collection
Review Chemistry, Analytical

Fabrication Methods for Microfluidic Devices: An Overview

Simon Scott et al.

Summary: Microfluidic devices have the potential to automate a wide variety of chemical and biological operations with higher efficiency and repeatability. Polymer-based devices offer advantages in terms of cost and biocompatibility. Different manufacturing approaches, including direct and replication methods, are described in this study.

MICROMACHINES (2021)

Add to Collection
Article Cell & Tissue Engineering

Human motor units in microfluidic devices are impaired by FUS mutations and improved by HDAC6 inhibition

Katarina Stoklund Dittlau et al.

Summary: This study established a versatile and reproducible in vitro model of a human motor unit to investigate the effects of ALS-causing mutations. It was observed that ALS-causing FUS mutations resulted in reduced neurite outgrowth, impaired neurite regrowth, and reduced NMJ numbers. Interestingly, the selective HDAC6 inhibitor Tubastatin A improved these outcomes, suggesting HDAC6 inhibition as a potential therapeutic strategy for ALS.

STEM CELL REPORTS (2021)

Add to Collection
Article Materials Science, Multidisciplinary

Herringbone Microfluidic Probe for Multiplexed Affinity-Capture of Prostate Circulating Tumor Cells

Ayoub Glia et al.

Summary: In this work, a novel herringbone microfluidic probe (HB-MFP) was developed for efficient capture of circulating tumor cells (CTCs) expressing specific antigens. The HB-MFP enables high throughput sample processing and offers potential for cancer diagnosis and treatment through multiplexed profiling of CTCs.

ADVANCED MATERIALS TECHNOLOGIES (2021)

Add to Collection
Article Multidisciplinary Sciences

Human colorectal cancer-on-chip model to study the microenvironmental influence on early metastatic spread

Carly Strelez et al.

Summary: The study investigates early invasive events in colorectal cancer using an in vitro organ-on-chip model, revealing differences in invasion abilities between aggressive and non-aggressive tumor cells, with potential for tuning tumor microenvironment to influence invasive capabilities.

ISCIENCE (2021)

Add to Collection
Article Engineering, Biomedical

Modeling nonalcoholic fatty liver disease on a liver lobule chip with dual blood supply

Kun Du et al.

Summary: This study develops a biomimetic liver lobule chip and establishes a more accurate on-chip NAFLD model, demonstrating for the first time the changes in lipid zonation in a liver lobule with the progression of NAFLD on a microfluidic chip. The application of the induced NAFLD model has shown promise in the prevention and reversibility of drug treatments, providing a platform for understanding NAFLD progression and identifying potential drug therapies.

ACTA BIOMATERIALIA (2021)

Add to Collection
Article Engineering, Biomedical

High-throughput microfluidic 3D biomimetic model enabling quantitative description of the human breast tumor microenvironment

Ilana Berger Fridman et al.

Summary: Cancer progression is driven by changes in tumor cells and surrounding stroma. The study demonstrates a high throughput microfluidic system for generating dynamic tumor-stroma scaffolds that mimic in vivo TME, with Alg/Alg-S promoting in vivo-like responses and potential therapeutic targets for breast cancer treatment. Formation of large tumor-derived vesicles in Alg/Alg-S scaffolds suggests a mechanism for tumor survival.

ACTA BIOMATERIALIA (2021)

Add to Collection
Article Chemistry, Analytical

Label-Free Multitarget Separation of Particles and Cells under Flow Using Acoustic, Electrophoretic, and Hydrodynamic Forces

Yupan Wu et al.

Summary: This study presents an integrated chip combining acoustic and electric fields for efficient and label-free separation of multiple cells and particles. It successfully integrates four sequential microfluidic modules for multitarget separation within a single platform. The platform has great potential in diverse diagnostic and analysis applications.

ANALYTICAL CHEMISTRY (2021)

Add to Collection
Review Biochemical Research Methods

Inertial microfluidics in contraction-expansion microchannels: A review

Di Jiang et al.

Summary: Inertial microfluidics has become a major trend in sample pretreatment, with contraction-expansion microchannels enhancing the efficiency of inertial microfluidics and allowing for more precise particle separation using vortex and secondary flow. Recent studies have focused on the use of viscoelastic fluids for precise particle separation at lower flow rates, particularly for delicate cells.

BIOMICROFLUIDICS (2021)

Add to Collection
Review Biochemical Research Methods

Degenerative disease-on-a-chip: Developing microfluidic models for rapid availability of newer therapies

Devashree Jahagirdar et al.

Summary: This article discusses the current status and potential of degenerative disease models developed using microfluidic platforms, highlighting the significance of these models for testing and screening biotherapeutic molecules and drugs.

BIOTECHNOLOGY JOURNAL (2021)

Add to Collection
Article Chemistry, Multidisciplinary

Active Micromixer of Microfluids via Plasmonic Marangoni Convection

Hiroaki Agawa et al.

Summary: Efficient chemical reactions in microfluidic devices face challenges due to laminar flow in narrow microchannels, making mixing difficult. This study aimed to develop a micromixer to control diffusion easily, and achieved efficient stirring using light-to-heat conversion on plasmonic metal nanostructures.

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN (2021)

Add to Collection
Article Mechanics

Electrophoretic motion of a non-uniformly charged particle in a viscoelastic medium in thin electrical double layer limit

Uddipta Ghosh et al.

Summary: The study analyzes the electrophoretic motion of non-uniformly charged particles in a viscoelastic medium, revealing significant differences in their behavior compared to Newtonian fluids. It shows that the particle's velocity strongly depends on its size and surface charge distribution in a viscoelastic medium, contrary to the established theory for weakly charged particles in Newtonian fluids. The presence of non-uniform surface charge enhances the influence of the medium's viscoelasticity on the particle's translational and angular velocities, with the effect depending strongly on the nature of surface charge distribution.

JOURNAL OF FLUID MECHANICS (2021)

Add to Collection
Article Chemistry, Multidisciplinary

A Gut-Brain Axis-on-a-Chip for studying transport across epithelial and endothelial barriers

Min-Hyeok Kim et al.

Summary: Recent research indicates that the gut luminal environment can impact behavior, emotion, and cognitive abilities in the brain via various signaling pathways, with exosomes potentially mediating the communication. Advances in organ-on-a-chip technology have led to the development of a modular microfluidic chip for studying the interaction between the gut and the brain, which showed promise in facilitating the transport of exosomes across barriers. This model represents a novel in vitro approach to studying Gut-Brain Axis interactions.

JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY (2021)

Add to Collection
Article Materials Science, Multidisciplinary

3D Printed Tooling for Injection Molded Microfluidics

Neil Convery et al.

Summary: This study demonstrates the use of 3D printing for inlays in injection moulding, reducing the skills, cost, and time required for microfluidic chip fabrication. The authors show that the 3D printed inlays are durable enough to produce a large number of parts and that devices can be designed, manufactured, and tested in a short period of time.

MACROMOLECULAR MATERIALS AND ENGINEERING (2021)

Add to Collection
Article Chemistry, Multidisciplinary

Role of nanotechnology behind the success of mRNA vaccines for COVID-19

Amit Khurana et al.

Summary: The emergency use authorization of two mRNA vaccines by the US-FDA has brought hope in addressing the COVID-19 pandemic. Nanotechnology has played a crucial role in the success of these vaccines, especially with the unique capabilities of lipid nanoparticles. This showcases the potential utility of nanomedicine in tackling global health problems.

NANO TODAY (2021)

Add to Collection
Article Engineering, Electrical & Electronic

Fabrication and characteristic study on mixing enhancement of a magnetofluidic mixer

Ran Zhou et al.

Summary: A new magnetofluidic mixer was developed for rapid and efficient mixing of two miscible fluids, utilizing magnetic field. Experimental and simulation results showed that the mixing efficiency was highest at specific angle and magnet width, providing great potential for optimization of biomedical and chemical mixing devices in the future.

SENSORS AND ACTUATORS A-PHYSICAL (2021)

Add to Collection
Review Chemistry, Analytical

Smart biosensors and intelligent devices for salivary biomarker detection

Xufeng Zheng et al.

Summary: This review focuses on the recent progress made in the design of smart biosensors and intelligent devices for salivary biomarker detection, including smart sensor design and highly integrated biodevices.

TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2021)

Add to Collection
Article Multidisciplinary Sciences

Acoustoelectronic nanotweezers enable dynamic and large-scale control of nanomaterials

Peiran Zhang et al.

Summary: This study introduces acoustoelectronic nanotweezers, which combine the precision of electronic tweezers with the large-field dynamic control of acoustic tweezers, demonstrating complex patterning of sub-100nm objects.

NATURE COMMUNICATIONS (2021)

Add to Collection
Review Nanoscience & Nanotechnology

Nanozymes in Point-of-Care Diagnosis: An Emerging Futuristic Approach for Biosensing

Bhaskar Das et al.

Summary: Nanozymes have attracted attention for their ability to mimic natural enzymes while overcoming their limitations. They offer advantages such as diverse activities, low cost, high stability, and compatibility, making them suitable for various biosensing applications. Their integration in point-of-care diagnostics shows potential, although challenges remain in achieving truly ASSURED solutions.

NANO-MICRO LETTERS (2021)

Add to Collection
Article Chemistry, Analytical

Design of a Hybrid Inertial and Magnetophoretic Microfluidic Device for CTCs Separation from Blood

Rohollah Nasiri et al.

Summary: Isolating circulating tumor cells (CTCs) from blood samples is crucial for cancer diagnosis and treatment, and microfluidics shows great potential in this area. Combining inertial and magnetic methods on a single chip was found to be effective in separating CTCs, with high recovery rates and purity levels.

MICROMACHINES (2021)

Add to Collection
Article Chemistry, Analytical

A Personalized Glomerulus Chip Engineered from Stem Cell-Derived Epithelium and Vascular Endothelium

Yasmin Roye et al.

Summary: This study engineered a personalized glomerulus chip system using human induced pluripotent stem cells, successfully mimicking the structure and some functions of the glomerular filtration barrier, and modeling glomerular injury and proteinuria. The research has the potential to advance studies of kidney disease mechanisms and the discovery of personalized therapies, and could serve as a blueprint for the development of more personalized organ chip and 'body-on-a-chip' models in the future.

MICROMACHINES (2021)

Add to Collection
Article Chemistry, Multidisciplinary

Ultrasensitive and Reusable Graphene Oxide-Modified Double-Interdigitated Capacitive (DIDC) Sensing Chip for Detecting SARS-CoV-2

Parshant Kumar Sharma et al.

Summary: This research demonstrates the successful detection of SARS-CoV-2 S1 proteins using a functionalized GrO-glazed DIDC biosensing platform, showing enhanced selectivity and rapid response. The platform exhibits good sensitivity, a wide detection range, low limit of detection, good linearity, and high selectivity against antigens.

ACS SENSORS (2021)

Add to Collection
Article Chemistry, Multidisciplinary

Mixing during Trapping Enabled a Continuous-Flow Microfluidic Smartphone Immunoassay Using Acoustic Streaming

Xian Chen et al.

Summary: A novel acoustic streaming tweezers-enabled microfluidic immunoassay was proposed, allowing for probe particles' purification, reaction, and sensing on the same chip under continuous-flow conditions. The high-speed microscale vortexes enable dynamic trapping and washing of the probe particles and enhance the capture efficiency of heterogeneous particle-based immunoassay through active mixing during trapping. This system achieved a limit of detection of 0.2 ng/mL and a dynamic response range from 0.3 to 10 ng/mL for prostate-specific antigen sensing with only 10 μL of sample in less than 15 minutes total assay time, making it suitable for on-site diagnosis applications.

ACS SENSORS (2021)

Add to Collection
Article Multidisciplinary Sciences

The fluid shear stress sensor TRPM7 regulates tumor cell intravasation

Christopher L. Yankaskas et al.

Summary: The study reveals a molecular mechanism by which cells avoid high shear during intravasation by activating TRPM7 channel to promote extracellular calcium influx, which then activates different pathways to coordinate the reversal of migration direction and avoid shear stress. Cells with higher TRPM7 activity levels intravasate less efficiently and establish less invasive metastatic lesions. This study provides a mechanistic interpretation for the role of shear stress and its sensor, TRPM7, in tumor cell intravasation.

SCIENCE ADVANCES (2021)

Add to Collection
Review Nanoscience & Nanotechnology

High-resolution two-photon polymerization: the most versatile technique for the fabrication of microneedle arrays

Zahra Faraji Rad et al.

Summary: Microneedle patches have gained popularity for drug/vaccine delivery and fluid sampling systems. Additive manufacturing techniques, like 2PP, allow for precise fabrication of microstructures such as microneedle arrays, overcoming limitations of traditional manufacturing methods.

MICROSYSTEMS & NANOENGINEERING (2021)

Add to Collection
Proceedings Paper Engineering, Biomedical

A MICROFLUDIC PLATFORM AS AN IN VITRO MODEL FOR BIOMEDICAL EXPERIMENTATION - A CELL MIGRATION STUDY

Nevena Milivojevic et al.

Summary: Preclinical experimentation requires reliable and physiological-relevant systems to mimic complex human physiology, with traditional models failing to replicate the native scenario. Emerging microfluidics-based models offer unprecedented ability to recreate the native habitat of cells, providing a valuable tool for studying critical biological processes.

2021 IEEE 21ST INTERNATIONAL CONFERENCE ON BIOINFORMATICS AND BIOENGINEERING (IEEE BIBE 2021) (2021)

Add to Collection
Review Chemistry, Analytical

Recent progress of inertial microfluidic-based cell separation

Xuefeng Xu et al.

Summary: Cell separation based on microfluidics is a promising technology for biomedical research, showing great potential in point-of-care testing applications. Inertial microfluidics, with its simple structure and high throughput, has attracted significant attention. Recent advancements in multistage channel structures for cell separation have been discussed, focusing on innovative designs and developments in composite and integrated channels. The review also highlights future prospects and challenges in the field of inertial microfluidic cell separation technology.

ANALYST (2021)

Add to Collection
Article Chemistry, Analytical

Gut-on-Chip microphysiological systems: Latest advances in the integration of sensing strategies and adoption of mature detection mechanisms

Maria Assunta Signore et al.

Summary: Collaborative efforts in microfabrication processes, cell culture, and tissue engineering have driven the advancement of Organ-on-Chip (OoC) technology, creating in vitro microphysiological models that mimic specific tissue and organ microenvironments. Gut-on-Chip (GoC) systems integrate sensing strategies to monitor physiological parameters related to intestinal function.

SENSING AND BIO-SENSING RESEARCH (2021)

Add to Collection
Article Biochemical Research Methods

Understanding and improving FDM 3D printing to fabricate high-resolution and optically transparent microfluidic devices

Reverson Fernandes Quero et al.

Summary: This study systematically investigates how to enhance the potential of FDM 3D printers for fabricating transparent microfluidic devices, achieving good results through adjustments of parameters and printing characteristics.

LAB ON A CHIP (2021)

Add to Collection
Article Biochemical Research Methods

High-throughput injection molded microfluidic device for single-cell analysis of spatiotemporal dynamics

Youngtaek Kim et al.

Summary: The newly designed injection molded microfluidic device addresses the inherent limitations of PDMS-manufactured devices and provides a more convenient way to study single-cell behaviors while saving time. The spatiotemporal dynamics in the device were demonstrated through experiments and computational simulations. This easy-to-use plastic microfluidic device promises to open a new approach for investigating the mechanisms of cell behavior at the single-cell level.

LAB ON A CHIP (2021)

Add to Collection
Review Materials Science, Biomaterials

Superoxide dismutase nanozymes: an emerging star for anti-oxidation

Hanqing Zhao et al.

Summary: Superoxide dismutases (SODs) play a crucial role in combating damage from reactive oxygen species in oxidative stress-related diseases. Nanozymes, as substitutes for SODs, offer better stability and cost-effectiveness.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

Add to Collection
Article Food Science & Technology

Real-time, selective, and low-cost detection of trace level SARS-CoV-2 spike-protein for cold-chain food quarantine

Jian Zhang et al.

Summary: This study presents a strategy for detecting trace level spike-protein from SARS-CoV-2, with fast detection, high sensitivity, wide linear range, and low cost, suitable for cold-chain food quarantine.

NPJ SCIENCE OF FOOD (2021)

Add to Collection
Article Chemistry, Multidisciplinary

Electrostatically excited liquid marble as a micromixer

Nhat-Khuong Nguyen et al.

Summary: This paper explores the use of electrostatic force to induce vibration and deformation in liquid marbles for improved mixing performance. Results demonstrate significant enhancement in mixing performance when they were actuated, with higher electric field strengths further promoting the mixing process. These findings highlight the potential of utilizing liquid marbles as high-performance micromixers through mechanisms of vibration and deformation.

REACTION CHEMISTRY & ENGINEERING (2021)

Add to Collection
Article Biochemical Research Methods

Goodbye fouling: a unique coaxial lamination mixer (CLM) enabled by two-photon polymerization for the stable production of monodisperse drug carrier nanoparticles

Peer Erfle et al.

Summary: The coaxial lamination mixer (CLM) enables efficient production of stable, scalable lipid nanoparticles loaded with poorly soluble drugs, ensuring high throughput parallelization.

LAB ON A CHIP (2021)

Add to Collection
Article Biochemical Research Methods

Synchronous control of magnetic particles and magnetized cells in a tri-axial magnetic field

Roozbeh Abedini-Nassab et al.

Summary: This study introduces a novel microfluidic platform for precise manipulation of single particles and magnetized cells, achieving simultaneous transport of multiple particles and demonstrating a curved transportation method. The technology has the potential for applications in the fields of lab-on-a-chip, single-cell biology, and drug screening.

LAB ON A CHIP (2021)

Add to Collection
Article Biochemical Research Methods

A microfluidic-integrated lateral flow recombinase polymerase amplification (MI-IF-RPA) assay for rapid COVID-19 detection

Dan Liu et al.

Summary: The MI-IF-RPA assay developed in this study offers a rapid and sensitive detection of SARS-CoV-2, integrating RT-RPA and LF detection systems into a single microfluidic chip. The assay provides easily interpretable results with a short testing time of approximately 30 minutes, showing high sensitivity and specificity, making it a cost-effective screening tool for resource-limited areas in complement to RT-PCR.

LAB ON A CHIP (2021)

Add to Collection
Article Chemistry, Analytical

Microfluidic-enabled magnetic labelling of nanovesicles for bioanalytical applications

Cornelia A. Hermann et al.

Summary: The study introduces a microfluidic method for labeling functional nanovesicles, avoiding the risk of conglomerate formation commonly observed in bulk reactions. Magnetic properties are beneficial for nanoparticles in improving separation capabilities.

ANALYST (2021)

Add to Collection
Review Chemistry, Multidisciplinary

Microfluidic Generation of Nanomaterials for Biomedical Applications

Xin Zhao et al.

SMALL (2020)

Add to Collection
Article Engineering, Biomedical

A heart-on-a-chip platform for online monitoring of contractile behavior via digital image processing and piezoelectric sensing technique

Mutsuhito Sakamiya et al.

MEDICAL ENGINEERING & PHYSICS (2020)

Add to Collection
Review Chemistry, Multidisciplinary

Microfluidic Platforms toward Rational Material Fabrication for Biomedical Applications

Qilong Zhao et al.

SMALL (2020)

Add to Collection
Article Chemistry, Analytical

Injection Molded Microfluidics for Establishing High-Density Single Cell Arrays in an Open Hydrogel Format

Ying Li et al.

ANALYTICAL CHEMISTRY (2020)

Add to Collection
Article Biotechnology & Applied Microbiology

A lung cancer-on-chip platform with integrated biosensors for physiological monitoring and toxicity assessment

Muhammad Asad Ullah Khalid et al.

BIOCHEMICAL ENGINEERING JOURNAL (2020)

Add to Collection
Article Biochemical Research Methods

Elimination of pseudo-negative conductance by coercive steady state in perm-selective ion transportation

Soonhyun Kwon et al.

BIOMICROFLUIDICS (2020)

Add to Collection
Review Energy & Fuels

Active and passive micromixers: A comprehensive review

Morteza Bayareh et al.

CHEMICAL ENGINEERING AND PROCESSING-PROCESS INTENSIFICATION (2020)

Add to Collection
Review Biochemistry & Molecular Biology

Enzyme immobilization onto the nanomaterials: Application in enzyme stability and prodrug-activated cancer therapy

Majid Sharifi et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

Add to Collection
Article Medicine, General & Internal

Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding

Roujian Lu et al.

LANCET (2020)

Add to Collection
Article Toxicology

Predicting tubular reabsorption with a human kidney proximal tubule tissue-on-a-chip and physiologically-based modeling

Courtney Sakolish et al.

TOXICOLOGY IN VITRO (2020)

Add to Collection
Article Multidisciplinary Sciences

Microengineered human blood-brain barrier platform for understanding nanoparticle transport mechanisms

Song Ih Ahn et al.

NATURE COMMUNICATIONS (2020)

Add to Collection
Review Biotechnology & Applied Microbiology

Nanoscale Drug Delivery Systems: From Medicine to Agriculture

Pablo Vega-Vasquez et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2020)

Add to Collection
Review Biophysics

Integration and synergy in protein-nanomaterial hybrids for biosensing: Strategies and in-field detection applications

Lin Zhang et al.

BIOSENSORS & BIOELECTRONICS (2020)

Add to Collection
Review Medicine, General & Internal

Nonalcoholic Steatohepatitis: A Review

Adam C. Sheka et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

Add to Collection
Article Chemistry, Analytical

Frequency Response of Induced-Charge Electrophoretic Metallic Janus Particles

Chong Shen et al.

MICROMACHINES (2020)

Add to Collection
Article Chemistry, Analytical

Differential Sorting of Microparticles Using Spiral Microchannels with Elliptic Configurations

Kaan Erdem et al.

MICROMACHINES (2020)

Add to Collection
Review Chemistry, Analytical

A Review of Secondary Flow in Inertial Microfluidics

Qianbin Zhao et al.

MICROMACHINES (2020)

Add to Collection
Article Chemistry, Multidisciplinary

Intrinsic Enzyme-like Activities of Cerium Oxide Nanocomposite and Its Application for Extracellular H2O2 Detection Using an Electrochemical Microfluidic Device

Negar Alizadeh et al.

ACS OMEGA (2020)

Add to Collection
Review Chemistry, Physical

Multiphase flow in microfluidics: From droplets and bubbles to the encapsulated structures

Amirmohammad Sattari et al.

ADVANCES IN COLLOID AND INTERFACE SCIENCE (2020)

Add to Collection
Review Chemistry, Analytical

Emerging applications of paper-based analytical devices for drug analysis: A review

Eka Noviana et al.

ANALYTICA CHIMICA ACTA (2020)

Add to Collection
Article Chemistry, Analytical

Microfluidic Immunoassays for Sensitive and Simultaneous Detection of IgG/IgM/Antigen of SARS-CoV-2 within 15 min

Qiuyuan Lin et al.

ANALYTICAL CHEMISTRY (2020)

Add to Collection
Review Energy & Fuels

An updated review on particle separation in passive microfluidic devices

Morteza Bayareh

CHEMICAL ENGINEERING AND PROCESSING-PROCESS INTENSIFICATION (2020)

Add to Collection
Article Chemistry, Analytical

Acoustic Microfluidics

Peiran Zhang et al.

ANNUAL REVIEW OF ANALYTICAL CHEMISTRY, VOL 13 (2020)

Add to Collection
Article Biophysics

An ultrasensitive biosensor for fast detection of Salmonella using 3D magnetic grid separation and urease catalysis

Yu Hou et al.

BIOSENSORS & BIOELECTRONICS (2020)

Add to Collection
Article Chemistry, Analytical

Understanding Interdependencies between Mechanical Velocity and Electrical Voltage in Electromagnetic Micromixers

Noori Kim et al.

MICROMACHINES (2020)

Add to Collection
Article Nanoscience & Nanotechnology

Phase-controlled field-effect micromixing using AC electroosmosis

Paresa Modarres et al.

MICROSYSTEMS & NANOENGINEERING (2020)

Add to Collection
Review Biotechnology & Applied Microbiology

Nanoscale Technologies in Highly Sensitive Diagnosis of Cardiovascular Diseases

Chaohong Shi et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2020)

Add to Collection
Article Chemistry, Multidisciplinary

Unified View of Magnetic Nanoparticle Separation under Magnetophoresis

Sim Siong Leong et al.

LANGMUIR (2020)

Add to Collection
Review Engineering, Biomedical

Gut-on-a-chip: Current progress and future opportunities

Nureddin Ashammakhi et al.

BIOMATERIALS (2020)

Add to Collection
Article Mechanics

On magnetophoretic separation of blood cells using Halbach array of magnets

Afshin Shiriny et al.

MECCANICA (2020)

Add to Collection
Article Multidisciplinary Sciences

Subtype-specific characterization of breast cancer invasion using a microfluidic tumor platform

Hye-ran Moon et al.

PLOS ONE (2020)

Add to Collection
Review Chemistry, Multidisciplinary

Microfluidic-Based Approaches in Targeted Cell/Particle Separation Based on Physical Properties: Fundamentals and Applications

Rohollah Nasiri et al.

SMALL (2020)

Add to Collection
Article Chemistry, Physical

3D Printing of Cell Culture Devices: Assessment and Prevention of the Cytotoxicity of Photopolymers for Stereolithography

Sebastian Kress et al.

MATERIALS (2020)

Add to Collection
Article Multidisciplinary Sciences

Rapid isothermal amplification and portable detection system for SARS-CoV-2

Anurup Ganguli et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Add to Collection
Article Engineering, Biomedical

High-Throughput Tumor-on-a-Chip Platform to Study Tumor-Stroma Interactions and Drug Pharmacokinetics

Chun-Wei Chi et al.

ADVANCED HEALTHCARE MATERIALS (2020)

Add to Collection
Article Chemistry, Analytical

Dielectrophoresis Separation of Platelets Using a Novel Zigzag Microchannel

Yanfang Guan et al.

MICROMACHINES (2020)

Add to Collection
Article Chemistry, Analytical

Fused Deposition Modeling of Microfluidic Chips in Polymethylmethacrylate

Frederik Kotz et al.

MICROMACHINES (2020)

Add to Collection
Article Materials Science, Biomaterials

Modeling Human Nonalcoholic Fatty Liver Disease (NAFLD) with an Organoids-on-a-Chip System

Yaqing Wang et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2020)

Add to Collection
Review Cardiac & Cardiovascular Systems

Global Burden of Cardiovascular Diseases and Risk Factors, 1990-2019 Update From the GBD 2019 Study

Gregory A. Roth et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2020)

Add to Collection
Proceedings Paper Engineering, Biomedical

A 3D printed wearable device for sweat analysis

Mahshid Padash et al.

2020 IEEE INTERNATIONAL SYMPOSIUM ON MEDICAL MEASUREMENTS AND APPLICATIONS (MEMEA) (2020)

Add to Collection
Article Engineering, Electrical & Electronic

Fabrication of a 3D microfluidic cell culture device for bone marrow-on-a-chip

Dionysia Kefallinou et al.

MICRO AND NANO ENGINEERING (2020)

Add to Collection
Article Multidisciplinary Sciences

Electric field-driven microfluidics for rapid CRISPR-based diagnostics and its application to detection of SARS-CoV-2

Ashwin Ramachandran et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Add to Collection
Article Biophysics

A modular brain-on-a-chip for modelling epileptic seizures with functionally connected human neuronal networks

Anssi Pelkonen et al.

BIOSENSORS & BIOELECTRONICS (2020)

Add to Collection
Article Biochemical Research Methods

Finger-powered fluidic actuation and mixing via MultiJet 3D printing

Eric Sweet et al.

LAB ON A CHIP (2020)

Add to Collection
Review Biochemical Research Methods

Focusing of sub-micrometer particles in microfluidic devices

Tianlong Zhang et al.

LAB ON A CHIP (2020)

Add to Collection
Article Biochemical Research Methods

Soft, skin-interfaced microfluidic systems with integrated enzymatic assays for measuring the concentration of ammonia and ethanol in sweat

Sung Bong Kim et al.

LAB ON A CHIP (2020)

Add to Collection
Article Biochemical Research Methods

Acoustic mixing in a dome-shaped chamber-based SAW (DC-SAW) device

Hyunjung Lim et al.

LAB ON A CHIP (2020)

Add to Collection
Review Materials Science, Biomaterials

Matrix stiffness-regulated cellular functions under different dimensionalities

Jiajun Zhong et al.

BIOMATERIALS SCIENCE (2020)

Add to Collection
Article Nanoscience & Nanotechnology

Electrohydrodynamic-Driven Micromixing for the Synthesis of Highly Monodisperse Nanoscale Liposomes

Paresa Modarres et al.

ACS APPLIED NANO MATERIALS (2020)

Add to Collection
Review Chemistry, Physical

Microfluidics for Biomedical Analysis

Yong Yang et al.

SMALL METHODS (2020)

Add to Collection
Article Biochemical Research Methods

An acoustofluidic device for efficient mixing over a wide range of flow rates

Hunter Bachman et al.

LAB ON A CHIP (2020)

Add to Collection
Article Biochemical Research Methods

Ultrafast star-shaped acoustic micromixer for high throughput nanoparticle synthesis

Nguyen Hoai An Le et al.

LAB ON A CHIP (2020)

Add to Collection
Review Medicine, Research & Experimental

Tumor circulome in the liquid biopsies for cancer diagnosis and prognosis

Jicheng Wu et al.

THERANOSTICS (2020)

Add to Collection
Article Engineering, Biomedical

The effects of monocytes on tumor cell extravasation in a 3D vascularized microfluidic model

A. Boussommier-Calleja et al.

BIOMATERIALS (2019)

Add to Collection
Article Chemistry, Analytical

Automated Droplet-Based Microfluidic Platform for Multiplexed Analysis of Biochemical Markers in Small Volumes

Diana F. Cedillo-Alcantar et al.

ANALYTICAL CHEMISTRY (2019)

Add to Collection
Article Biophysics

Paper microfluidic device for early diagnosis and prognosis of acute myocardial infarction via quantitative multiplex cardiac biomarker detection

Wei Yin Lim et al.

BIOSENSORS & BIOELECTRONICS (2019)

Add to Collection
Article Biotechnology & Applied Microbiology

Three-dimensional microfluidic tumor-macrophage system for breast cancer cell invasion

Shengli Mi et al.

BIOTECHNOLOGY AND BIOENGINEERING (2019)

Add to Collection
Article Physics, Applied

Magnetic manipulation on the unlabeled nonmagnetic particles

Yongqing He et al.

INTERNATIONAL JOURNAL OF MODERN PHYSICS B (2019)

Add to Collection
Article Engineering, Electrical & Electronic

Microfluidic platforms for cell cultures and investigations

Maria Laura Coluccio et al.

MICROELECTRONIC ENGINEERING (2019)

Add to Collection
Article Chemistry, Analytical

Modeling the AC Electrokinetic Behavior of Semiconducting Spheres

Pablo Garcia-Sanchez et al.

MICROMACHINES (2019)

Add to Collection
Review Chemistry, Multidisciplinary

Nanomaterials Exhibiting Enzyme-Like Properties (Nanozymes): Current Advances and Future Perspectives

Sanjay Singh

FRONTIERS IN CHEMISTRY (2019)

Add to Collection
Review Materials Science, Multidisciplinary

Advances of Microfluidics in Biomedical Engineering

Qifeng Zhong et al.

ADVANCED MATERIALS TECHNOLOGIES (2019)

Add to Collection
Review Chemistry, Multidisciplinary

Nano-Cell Interactions of Non-Cationic Bionanomaterials

Lok Wai Cola Ho et al.

ACCOUNTS OF CHEMICAL RESEARCH (2019)

Add to Collection
Article Chemistry, Analytical

Continuous Particle Trapping, Switching, and Sorting Utilizing a Combination of Dielectrophoresis and Alternating Current Electrothermal Flow

Haizhen Sun et al.

ANALYTICAL CHEMISTRY (2019)

Add to Collection
Article Oncology

A Microfluidic Chip Enables Isolation of Exosomes and Establishment of Their Protein Profiles and Associated Signaling Pathways in Ovarian Cancer

Kalpana Deepa Priya Dorayappan et al.

CANCER RESEARCH (2019)

Add to Collection
Article Materials Science, Paper & Wood

A wearable, cotton thread/paper-based microfluidic device coupled with smartphone for sweat glucose sensing

Gang Xiao et al.

CELLULOSE (2019)

Add to Collection
Article Engineering, Electrical & Electronic

PDMS membrane filter with nano-slit array fabricated using three-dimensional silicon mold for the concentration of particles with bacterial size range

Young-Ho Nam et al.

MICROELECTRONIC ENGINEERING (2019)

Add to Collection
Article Chemistry, Analytical

Comparison of Micro-Mixing in Time Pulsed Newtonian Fluid and Viscoelastic Fluid

Meng Zhang et al.

MICROMACHINES (2019)

Add to Collection
Review Biochemical Research Methods

Biomimetic human lung-on-a-chip for modeling disease investigation

Kaiyan Li et al.

BIOMICROFLUIDICS (2019)

Add to Collection
Article Multidisciplinary Sciences

Bioinspired lipoproteins-mediated photothermia remodels tumor stroma to improve cancer cell accessibility of second nanoparticles

Tao Tan et al.

NATURE COMMUNICATIONS (2019)

Add to Collection
Review Nanoscience & Nanotechnology

Acoustofluidic separation of cells and particles

Mengxi Wu et al.

MICROSYSTEMS & NANOENGINEERING (2019)

Add to Collection
Article Biochemical Research Methods

Low frequency cyclical potentials for fine tuning insulator-based dielectrophoretic separations

Cody J. Lentz et al.

BIOMICROFLUIDICS (2019)

Add to Collection
Article Pharmacology & Pharmacy

Fabrication and finite element analysis of stereolithographic 3D printed microneedles for transdermal delivery of model dyes across human skin in vitro

Iakovos Xenikakis et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2019)

Add to Collection
Article Acoustics

Acoustically Driven Micromixing: Effect of Transducer Geometry

Edmund Lim et al.

IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL (2019)

Add to Collection
Article Materials Science, Biomaterials

3D printed microneedle patches using stereolithography (SLA) for intradermal insulin delivery

Sophia N. Economidou et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2019)

Add to Collection
Article Chemistry, Analytical

Characterization of Au@PtNP/GO nanozyme and its application to electrochemical microfluidic devices for quantification of hydrogen peroxide

Euna Ko et al.

SENSORS AND ACTUATORS B-CHEMICAL (2019)

Add to Collection
Article Biochemical Research Methods

Simultaneous detection and quantification of DNA and protein biomarkers in spectrum of cardiovascular diseases in a microfluidic microbead chip

Franziska Dinter et al.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2019)

Add to Collection
Article Chemistry, Analytical

Electrokinetically Driven Exosome Separation and Concentration Using Dielectrophoretic-Enhanced PDMS-Based Microfluidics

Sergio Ayala-Mar et al.

ANALYTICAL CHEMISTRY (2019)

Add to Collection
Article Engineering, Biomedical

A virus-induced kidney disease model based on organ-on-a-chip: Pathogenesis exploration of virus-related renal dysfunctions

Ji Wang et al.

BIOMATERIALS (2019)

Add to Collection
Article Engineering, Biomedical

A three-dimensional immunocompetent intestine-on-chip model as in vitro platform for functional and microbial interaction studies

Michelle Maurer et al.

BIOMATERIALS (2019)

Add to Collection
Article Engineering, Biomedical

Characterizing the invasion of different breast cancer cell lines with distinct E-cadherin status in 3D using a microfluidic system

H. Eslami Amirabadi et al.

BIOMEDICAL MICRODEVICES (2019)

Add to Collection
Article Biology

Microfluidic method reduces osmotic stress injury to oocytes during cryoprotectant addition and removal processes in porcine oocytes

Yingying Guo et al.

CRYOBIOLOGY (2019)

Add to Collection
Article Chemistry, Multidisciplinary

Isolation and Profiling of Circulating Tumor-Associated Exosomes Using Extracellular Vesicular Lipid-Protein Binding Affinity Based Microfluidic Device

Yoon-Tae Kang et al.

SMALL (2019)

Add to Collection
Review Chemistry, Analytical

The technology tree in the design of glucose biosensors

Viviana Scognamiglio et al.

TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2019)

Add to Collection
Article Nanoscience & Nanotechnology

Bends in magnetophoretic conductors

Roozbeh Abedini-Nassab et al.

AIP ADVANCES (2019)

Add to Collection
Article Biophysics

An integrated microfluidic system with field-effect-transistor sensor arrays for detecting multiple cardiovascular biomarkers from clinical samples

Anirban Sinha et al.

BIOSENSORS & BIOELECTRONICS (2019)

Add to Collection
Article Engineering, Electrical & Electronic

An efficient micromixer combining oscillatory flow and divergent circular chambers

J. W. Wu et al.

MICROSYSTEM TECHNOLOGIES-MICRO-AND NANOSYSTEMS-INFORMATION STORAGE AND PROCESSING SYSTEMS (2019)

Add to Collection
Article Nanoscience & Nanotechnology

The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs

Akin Akinc et al.

NATURE NANOTECHNOLOGY (2019)

Add to Collection
Review Chemistry, Physical

Immobilized Enzymes in Biosensor Applications

Hoang Hiep Nguyen et al.

MATERIALS (2019)

Add to Collection
Article Chemistry, Multidisciplinary

Photothermal Therapy Promotes Tumor Infiltration and Antitumor Activity of CAR T Cells

Qian Chen et al.

ADVANCED MATERIALS (2019)

Add to Collection
Article Multidisciplinary Sciences

Manipulating rod-shaped bacteria with optical tweezers

Zheng Zhang et al.

SCIENTIFIC REPORTS (2019)

Add to Collection
Article Chemistry, Multidisciplinary

Three-dimensional paper-based microfluidic electrochemical integrated devices (3D-PMED) for wearable electrochemical glucose detection

Qingpeng Cao et al.

RSC ADVANCES (2019)

Add to Collection
Review Oncology

Modelling cancer in microfluidic human organs-on-chips

Alexandra Sontheimer-Phelps et al.

NATURE REVIEWS CANCER (2019)

Add to Collection
Article Biochemical Research Methods

An ultra-rapid acoustic micromixer for synthesis of organic nanoparticles

M. Reza Rasouli et al.

LAB ON A CHIP (2019)

Add to Collection
Article Chemistry, Multidisciplinary

Multiplexed immunophenotyping of circulating exosomes on nano-engineered ExoProfile chip towards early diagnosis of cancer

Peng Zhang et al.

CHEMICAL SCIENCE (2019)

Add to Collection
Review Chemistry, Analytical

Microfluidic Electrochemical Devices for Biosensing

Noel Nesakumar et al.

JOURNAL OF ANALYSIS AND TESTING (2019)

Add to Collection
Article Materials Science, Multidisciplinary

Protein-Protected Porous Bimetallic AgPt Nanoparticles with pH-Switchable Peroxidase/Catalase-Mimicking Activity

Mustafa Gharib et al.

ACS MATERIALS LETTERS (2019)

Add to Collection
Article Multidisciplinary Sciences

Human Intestinal Morphogenesis Controlled by Transepithelial Morphogen Gradient and Flow-Dependent Physical Cues in a Microengineered Gut-on-a-Chip

Woojung Shin et al.

ISCIENCE (2019)

Add to Collection
Review Chemistry, Multidisciplinary

Metal and metal-oxide nanozymes: bioenzymatic characteristics, catalytic mechanism, and eco-environmental applications

Wenjun Chen et al.

NANOSCALE (2019)

Add to Collection
Article Chemistry, Multidisciplinary

Converting the personalized biomolecular corona of graphene oxide nanoflakes into a high-throughput diagnostic test for early cancer detection

Massimiliano Papi et al.

NANOSCALE (2019)

Add to Collection
Review Chemistry, Multidisciplinary

Nanozyme: new horizons for responsive biomedical applications

Dawei Jiang et al.

CHEMICAL SOCIETY REVIEWS (2019)

Add to Collection
Article Physics, Fluids & Plasmas

Inertial Micromixing in Curved Serpentine Micromixers with Different Curve Angles

Hossein Alijani et al.

FLUIDS (2019)

Add to Collection
Article Materials Science, Biomaterials

A Human Liver-on-a-Chip Platform for Modeling Nonalcoholic Fatty Liver Disease

Soufian Lasli et al.

ADVANCED BIOSYSTEMS (2019)

Add to Collection
Article Chemistry, Analytical

Integrated Microfluidic Devices Fabricated in Poly (Methyl Methacrylate) (PMMA) for On-site Therapeutic Drug Monitoring of Aminoglycosides in Whole Blood

Zaidon T. Al-aqbi et al.

BIOSENSORS-BASEL (2019)

Add to Collection
Article Chemistry, Analytical

Enzymatic Low Volume Passive Sweat Based Assays for Multi-Biomarker Detection

Ashlesha Bhide et al.

BIOSENSORS-BASEL (2019)

Add to Collection
Review Chemistry, Analytical

Enzyme-Based Electrochemical Biosensors for Microfluidic Platforms to Detect Pharmaceutical Residues in Wastewater

Ana Lucia Campana et al.

BIOSENSORS-BASEL (2019)

Add to Collection
Review Chemistry, Analytical

Droplets for Sampling and Transport of Chemical Signals in Biosensing: A Review

Shilun Feng et al.

BIOSENSORS-BASEL (2019)

Add to Collection
Article Chemistry, Analytical

Microfluidic paper-based device for colorimetric determination of glucose based on a metal-organic framework acting as peroxidase mimetic

Inmaculada Ortiz-Gomez et al.

MICROCHIMICA ACTA (2018)

Add to Collection
Review Chemistry, Analytical

Review on microfluidic paper-based analytical devices towards commercialisation

Tugce Akyazi et al.

ANALYTICA CHIMICA ACTA (2018)

Add to Collection
Review Chemistry, Multidisciplinary

Carbon Nanozymes: Enzymatic Properties, Catalytic Mechanism, and Applications

Hanjun Sun et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2018)

Add to Collection
Article Optics

Optics tweezers for trapping in a microfluidic environment

R. Kampmann et al.

APPLIED OPTICS (2018)

Add to Collection
Article Biotechnology & Applied Microbiology

Gut-liver on a chip toward an in vitro model of hepatic steatosis

Seung Yeon Lee et al.

BIOTECHNOLOGY AND BIOENGINEERING (2018)

Add to Collection
Review Chemistry, Multidisciplinary

Microfluidic fabrication of microparticles for biomedical applications

Wen Li et al.

CHEMICAL SOCIETY REVIEWS (2018)

Add to Collection
Article Engineering, Electrical & Electronic

AC electrothermal mixing for high conductive biofluids by arc-electrodes

Jiyu Meng et al.

JOURNAL OF MICROMECHANICS AND MICROENGINEERING (2018)

Add to Collection
Article Biochemical Research Methods

Fully automated, on-site isolation of cfDNA from whole blood for cancer therapy monitoring

Chi-Ju Kim et al.

LAB ON A CHIP (2018)

Add to Collection
Article Biochemical Research Methods

Fundamentals of rapid injection molding for microfluidic cell-based assays

Ulri N. Lee et al.

LAB ON A CHIP (2018)

Add to Collection
Review Biochemical Research Methods

Recent progress of particle migration in viscoelastic fluids

Dan Yuan et al.

LAB ON A CHIP (2018)

Add to Collection
Article Chemistry, Multidisciplinary

On the Impact of Electrostatic Correlations on the Double-Layer Polarization of a Spherical Particle in an Alternating Current Field

Elaheh Alidoosti et al.

LANGMUIR (2018)

Add to Collection
Article Physics, Applied

Microfluidic mixing through oscillatory transverse perturbations

J. W. Wu et al.

MODERN PHYSICS LETTERS B (2018)

Add to Collection
Article Biotechnology & Applied Microbiology

Lipid Nanoparticle-Delivered Chemically Modified mRNA Restores Chloride Secretion in Cystic Fibrosis

Ema Robinson et al.

MOLECULAR THERAPY (2018)

Add to Collection
Article Chemistry, Analytical

Micromixing using swirling induced by three-dimensional dual surface acoustic waves (3D-dSAW)

Jeonghun Nam et al.

SENSORS AND ACTUATORS B-CHEMICAL (2018)

Add to Collection
Article Chemistry, Analytical

Trapping, sorting and transferring of micro-particles and live cells using electric current-induced thermal tweezers

Hengji Cong et al.

SENSORS AND ACTUATORS B-CHEMICAL (2018)

Add to Collection
Article Chemistry, Multidisciplinary

Combining Multiplex SERS Nanovectors and Multivariate Analysis for In Situ Profiling of Circulating Tumor Cell Phenotype Using a Microfluidic Chip

Yizhi Zhang et al.

SMALL (2018)

Add to Collection
Article Chemistry, Analytical

Mimicking peroxidase activity of Co-2(OH)(2)CO3-CeO2 nanocomposite for smartphone based detection of tumor marker using paper-based microfluidic immunodevice

Negar Alizadeh et al.

TALANTA (2018)

Add to Collection
Review Chemistry, Analytical

Nanozyme: An emerging alternative to natural enzyme for biosensing and immunoassay

Qingqing Wang et al.

TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2018)

Add to Collection
Article Multidisciplinary Sciences

Engineered nanointerfaces for microfluidic isolation and molecular profiling of tumor-specific extracellular vesicles

Eduardo Reategui et al.

NATURE COMMUNICATIONS (2018)

Add to Collection
Article Chemistry, Multidisciplinary

The shape effect on polymer nanoparticle transport in a blood vessel

C. G. Uhl et al.

RSC ADVANCES (2018)

Add to Collection
Article Multidisciplinary Sciences

Acoustic impedance matched buffers enable separation of bacteria from blood cells at high cell concentrations

Pelle Ohlsson et al.

SCIENTIFIC REPORTS (2018)

Add to Collection
Article Engineering, Biomedical

Microfluidic Tumor-Vascular Model to Study Breast Cancer Cell Invasion and Intravasation

Supriya Nagaraju et al.

ADVANCED HEALTHCARE MATERIALS (2018)

Add to Collection
Article Chemistry, Analytical

Fabricating Microstructures on Glass for Microfluidic Chips by Glass Molding Process

Tao Wang et al.

MICROMACHINES (2018)

Add to Collection
Review Pharmacology & Pharmacy

Transporter-Guided Delivery of Nanoparticles to Improve Drug Permeation across Cellular Barriers and Drug Exposure to Selective Cell Types

Longfa Kou et al.

FRONTIERS IN PHARMACOLOGY (2018)

Add to Collection
Article Chemistry, Analytical

Magnetic-Based Microfluidic Device for On-Chip Isolation and Detection of Tumor-Derived Exosomes

Huiying Xu et al.

ANALYTICAL CHEMISTRY (2018)

Add to Collection
Article Physics, Applied

Particle separation in surface acoustic wave microfluidic devices using reprogrammable, pseudo-standing waves

Gergely Simon et al.

APPLIED PHYSICS LETTERS (2018)

Add to Collection
Article Biochemical Research Methods

Detecting miRNA biomarkers from extracellular vesicles for cardiovascular disease with a microfluidic system

Hong-Lin Cheng et al.

LAB ON A CHIP (2018)

Add to Collection
Article Chemistry, Analytical

Fabrication of a Urea Biosensor for Real-Time Dynamic Fluid Measurement

Kyunghee Kim et al.

SENSORS (2018)

Add to Collection
Article Chemistry, Analytical

Graphene oxide-gold nanozyme for highly sensitive electrochemical detection of hydrogen peroxide

Ga Hyun Jin et al.

SENSORS AND ACTUATORS B-CHEMICAL (2018)

Add to Collection
Article Chemistry, Analytical

Magnetophoretic separation of diamagnetic particles through parallel ferrofluid streams

Ahmed Munaz et al.

SENSORS AND ACTUATORS B-CHEMICAL (2018)

Add to Collection
Article Multidisciplinary Sciences

Bridging the scales in high-throughput dielectrophoretic (bio-) particle separation in porous media

Georg R. Pesch et al.

SCIENTIFIC REPORTS (2018)

Add to Collection
Review Biotechnology & Applied Microbiology

Nano based drug delivery systems: recent developments and future prospects

Jayanta Kumar Patra et al.

JOURNAL OF NANOBIOTECHNOLOGY (2018)

Add to Collection
Article Engineering, Biomedical

Microfluidic Device for Cell Trapping with Carbon Electrodes Using Dielectrophoresis

Paridhi Puri et al.

BIOMEDICAL MICRODEVICES (2018)

Add to Collection
Article Nanoscience & Nanotechnology

An efficient micromixer actuated by induced-charge electroosmosis using asymmetrical floating electrodes

Kailiang Zhang et al.

MICROFLUIDICS AND NANOFLUIDICS (2018)

Add to Collection
Article Chemistry, Multidisciplinary

A Sample-to-Targeted Gene Analysis Biochip for Nanofluidic Manipulation of Solid-Phase Circulating Tumor Nucleic Acid Amplification in Liquid Biopsies

Kevin M. Koo et al.

ACS SENSORS (2018)

Add to Collection
Article Multidisciplinary Sciences

Microphysiological 3D model of amyotrophic lateral sclerosis (ALS) from human iPS-derived muscle cells and optogenetic motor neurons

Tatsuya Osaki et al.

SCIENCE ADVANCES (2018)

Add to Collection
Article Biochemical Research Methods

Microfluidic-based solid phase extraction of cell free DNA

Camila D. M. Campos et al.

LAB ON A CHIP (2018)

Add to Collection
Review Engineering, Multidisciplinary

A Review of Current Methods in Microfluidic Device Fabrication and Future Commercialization Prospects

Bruce K. Gale et al.

INVENTIONS (2018)

Add to Collection
Article Chemistry, Medicinal

Theranostic Hyaluronic Acid-Iron Micellar Nanoparticles for Magnetic-Field-Enhanced invivo Cancer Chemotherapy

Guohao Wang et al.

CHEMMEDCHEM (2018)

Add to Collection
Article Engineering, Chemical

Enhancing liquid micromixing using low-frequency rotating nanoparticles

Shahab Boroun et al.

AICHE JOURNAL (2017)

Add to Collection
Article Biochemical Research Methods

Enhanced model-based design of a high-throughput three dimensional micromixer driven by alternating-current electrothermal flow

Yupan Wu et al.

ELECTROPHORESIS (2017)

Add to Collection
Article Engineering, Biomedical

Double-Mode Microparticle Manipulation by Tunable Secondary Flow in Microchannel With Arc-Shaped Groove Arrays

Qianbin Zhao et al.

IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS (2017)

Add to Collection
Article Chemistry, Multidisciplinary

Thermally triggered release of the bacteriophage endolysin CHAPK and the bacteriocin lysostaphin for the control of methicillin resistant Staphylococcus aureus (MRSA)

Hollie Hathaway et al.

JOURNAL OF CONTROLLED RELEASE (2017)

Add to Collection
Article Biochemical Research Methods

Microfluidic-based high-throughput optical trapping of nanoparticles

Abhay Kotnala et al.

LAB ON A CHIP (2017)

Add to Collection
Review Biochemical Research Methods

Microfluidics for exosome isolation and analysis: enabling liquid biopsy for personalized medicine

Jose C. Contreras-Naranjo et al.

LAB ON A CHIP (2017)

Add to Collection
Review Biochemical Research Methods

Passive and active droplet generation with microfluidics: a review

Pingan Zhu et al.

LAB ON A CHIP (2017)

Add to Collection
Article Biochemical Research Methods

On-chip human microvasculature assay for visualization and quantification of tumor cell extravasation dynamics

Michelle B. Chen et al.

NATURE PROTOCOLS (2017)

Add to Collection
Article Multidisciplinary Sciences

Isolation of exosomes from whole blood by integrating acoustics and microfluidics

Mengxi Wu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Add to Collection
Review Polymer Science

Dynamically tunable cell culture platforms for tissue engineering and mechanobiology

Koichiro Uto et al.

PROGRESS IN POLYMER SCIENCE (2017)

Add to Collection
Article Engineering, Electrical & Electronic

Rapid mixing in micromixers using magnetic field

Davoud Nouri et al.

SENSORS AND ACTUATORS A-PHYSICAL (2017)

Add to Collection
Article Chemistry, Analytical

Determination of stability characteristics for electrochemical biosensors via thermally accelerated ageing

Peter Panjan et al.

TALANTA (2017)

Add to Collection
Article Multidisciplinary Sciences

Profiling protein expression in circulating tumour cells using microfluidic western blotting

Elly Sinkala et al.

NATURE COMMUNICATIONS (2017)

Add to Collection
Article Multidisciplinary Sciences

A Biomimetic Microfluidic Tumor Microenvironment Platform Mimicking the EPR Effect for Rapid Screening of Drug Delivery Systems

Yuan Tang et al.

SCIENTIFIC REPORTS (2017)

Add to Collection
Article Materials Science, Biomaterials

Redox-responsive dextran based theranostic nanoparticles for near-infrared/magnetic resonance imaging and magnetically targeted photodynamic therapy

Zexuan Ding et al.

BIOMATERIALS SCIENCE (2017)

Add to Collection
Article Chemistry, Analytical

Paper-Based Colorimetric Biosensor for Tear Glucose Measurements

Ellen Flavia Moreira Gabriel et al.

MICROMACHINES (2017)

Add to Collection
Article Multidisciplinary Sciences

Microfluidic sorting of intrinsically magnetic cells under visual control

Ahne Myklatun et al.

SCIENTIFIC REPORTS (2017)

Add to Collection
Article Multidisciplinary Sciences

Monolithic Chip for High-throughput Blood Cell Depletion to Sort Rare Circulating Tumor Cells

Fabio Fachin et al.

SCIENTIFIC REPORTS (2017)

Add to Collection
Article Nanoscience & Nanotechnology

Influence of Particle Geometry on Gastrointestinal Transit and Absorption following Oral Administration

Dong Li et al.

ACS APPLIED MATERIALS & INTERFACES (2017)

Add to Collection
Article Engineering, Chemical

Numerical and experimental investigations of chaotic mixing behavior in an oscillating feedback micromixer

Tingliang Xie et al.

CHEMICAL ENGINEERING SCIENCE (2017)

Add to Collection
Article Engineering, Biomedical

A microfluidic platform for modeling metastatic cancer cell matrix invasion

Laura Blaha et al.

BIOFABRICATION (2017)

Add to Collection
Article Biochemical Research Methods

Particle concentrating and sorting under a rotating electric field by direct optical-liquid heating in a microfluidics chip

Yu-Liang Chen et al.

BIOMICROFLUIDICS (2017)

Add to Collection
Article Biochemical Research Methods

Dipole and multipole models of dielectrophoresis for a non-negligible particle size: Simulations and experiments

Tomas Michalek et al.

ELECTROPHORESIS (2017)

Add to Collection
Review Integrative & Complementary Medicine

Cryopreservation and its clinical applications

Tae Hoon Jang et al.

INTEGRATIVE MEDICINE RESEARCH (2017)

Add to Collection
Article Nanoscience & Nanotechnology

ZnO-Based Microfluidic pH Sensor: A Versatile Approach for Quick Recognition of Circulating Tumor Cells in Blood

Ganesh Kumar Mani et al.

ACS APPLIED MATERIALS & INTERFACES (2017)

Add to Collection
Article Engineering, Environmental

Pulsatile micromixing using water-head-driven microfluidic oscillators

Zhenglin Li et al.

CHEMICAL ENGINEERING JOURNAL (2017)

Add to Collection
Article Biophysics

Near-infrared mediated quantum dots and paclitaxel co-loaded nanostructured lipid carriers for cancer theragnostic

Livesey David Olerile et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2017)

Add to Collection
Review Biotechnology & Applied Microbiology

Microfluidics for cryopreservation

Gang Zhao et al.

BIOTECHNOLOGY ADVANCES (2017)

Add to Collection
Article Neurosciences

Permeability across a novel microfluidic blood-tumor barrier model

Tori B. Terrell-Hall et al.

FLUIDS AND BARRIERS OF THE CNS (2017)

Add to Collection
Article Biochemistry & Molecular Biology

Small molecule absorption by PDMS in the context of drug response bioassays

B. J. van Meer et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)

Add to Collection
Article Nanoscience & Nanotechnology

Rhipsalis (Cactaceae)-like Hierarchical Structure Based Microfluidic Chip for Highly Efficient Isolation of Rare Cancer Cells

Shuangqian Yan et al.

ACS APPLIED MATERIALS & INTERFACES (2016)

Add to Collection
Article Nanoscience & Nanotechnology

Design and Construction of a Multi-Organ Microfluidic Chip Mimicking the in vivo Microenvironment of Lung Cancer Metastasis

Zhiyun Xu et al.

ACS APPLIED MATERIALS & INTERFACES (2016)

Add to Collection
Review Pharmacology & Pharmacy

Polysaccharide-based nanoparticles for theranostic nanomedicine

M. Swierczewska et al.

ADVANCED DRUG DELIVERY REVIEWS (2016)

Add to Collection
Article Cell Biology

Tumor cell intravasation

Serena P. H. Chiang et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2016)

Add to Collection
Review Biophysics

Fabrication techniques for microfluidic paper-based analytical devices and their applications for biological testing: A review

Yanyan Xia et al.

BIOSENSORS & BIOELECTRONICS (2016)

Add to Collection
Article Cell Biology

A 3D alcoholic liver disease model on a chip

JaeSeo Lee et al.

INTEGRATIVE BIOLOGY (2016)

Add to Collection
Review Cell Biology

Three-dimensional models for studying development and disease: moving on from organisms to organs-on-a-chip and organoids

E. L. Jackson et al.

INTEGRATIVE BIOLOGY (2016)

Add to Collection
Article Biochemistry & Molecular Biology

Novel alginate-stabilized doxorubicin-loaded nanodroplets for ultrasounic theranosis of breast cancer

Fatemeh Baghbani et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2016)

Add to Collection
Article Biophysics

Biomedical microfluidic devices by using low-cost fabrication techniques: A review

Vera Faustino et al.

JOURNAL OF BIOMECHANICS (2016)

Add to Collection
Article Materials Science, Multidisciplinary

Particles Sorting in Micro Channel Using Designed Micro Electromagnets of Magnetic Field Gradient

Yung-Chiang Chung et al.

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS (2016)

Add to Collection
Review Biochemical Research Methods

Droplet microfluidics for microbiology: techniques, applications and challenges

Tomasz S. Kaminski et al.

LAB ON A CHIP (2016)

Add to Collection
Article Medicine, Research & Experimental

Effect of the Route of Administration and PEGylation of Poly(amidoamine) Dendrimers on Their Systemic and Lung Cellular Biodistribution

Qian Zhong et al.

MOLECULAR PHARMACEUTICS (2016)

Add to Collection
Article Multidisciplinary Sciences

Oriented collagen fibers direct tumor cell intravasation

Weijing Han et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Add to Collection
Article Chemistry, Multidisciplinary

Continuous Flow Deformability-Based Separation of Circulating Tumor Cells Using Microfluidic Ratchets

Emily S. Park et al.

SMALL (2016)

Add to Collection
Article Instruments & Instrumentation

An inverted micro-mixer based on a magnetically-actuated cilium made of Fe doped PDMS

Fengli Liu et al.

SMART MATERIALS AND STRUCTURES (2016)

Add to Collection
Review Biotechnology & Applied Microbiology

Vascularization and Angiogenesis in Tissue Engineering: Beyond Creating Static Networks

Jeroen Rouwkema et al.

TRENDS IN BIOTECHNOLOGY (2016)

Add to Collection
Article Multidisciplinary Sciences

3D Printed Multimaterial Microfluidic Valve

Steven J. Keating et al.

PLOS ONE (2016)

Add to Collection
Article Multidisciplinary Sciences

Continuous particle separation using pressure-driven flow-induced miniaturizing free-flow electrophoresis (PDF-induced μ-FFE)

Hyungkook Jeon et al.

SCIENTIFIC REPORTS (2016)

Add to Collection
Article Multidisciplinary Sciences

Quantitative Study of Cell Invasion Process under Extracellular Stimulation of Cytokine in a Microfluidic Device

Kin Fong Lei et al.

SCIENTIFIC REPORTS (2016)

Add to Collection
Article Multidisciplinary Sciences

Mechanically activated artificial cell by using microfluidics

Kenneth K. Y. Ho et al.

SCIENTIFIC REPORTS (2016)

Add to Collection
Article Multidisciplinary Sciences

Inertial Focusing of Microparticles in Curvilinear Microchannels

Arzu Ozbey et al.

SCIENTIFIC REPORTS (2016)

Add to Collection
Article Multidisciplinary Sciences

Thermal gradient induced tweezers for the manipulation of particles and cells

Jiajie Chen et al.

SCIENTIFIC REPORTS (2016)

Add to Collection
Article Nanoscience & Nanotechnology

Multifunctional Biocompatible Graphene Oxide Quantum Dots Decorated Magnetic Nanoplatform for Efficient Capture and Two-Photon Imaging of Rare Tumor Cells

Yongliang Shi et al.

ACS APPLIED MATERIALS & INTERFACES (2015)

Add to Collection
Article Nanoscience & Nanotechnology

Hybrid Lipid-Capped Mesoporous Silica for Stimuli-Responsive Drug Release and Overcoming Multidrug Resistance

Ning Han et al.

ACS APPLIED MATERIALS & INTERFACES (2015)

Add to Collection
Article Chemistry, Analytical

Continuous Microfluidic Particle Separation via Elasto-Inertial Pinched Flow Fractionation

Xinyu Lu et al.

ANALYTICAL CHEMISTRY (2015)

Add to Collection
Article Chemistry, Analytical

Inertia-Enhanced Pinched Flow Fractionation

Xinyu Lu et al.

ANALYTICAL CHEMISTRY (2015)

Add to Collection
Article Biophysics

Absolute quantification of lung cancer related microRNA by droplet digital PCR

Ping Wang et al.

BIOSENSORS & BIOELECTRONICS (2015)

Add to Collection
Review Medicine, General & Internal

Septic Shock Advances in Diagnosis and Treatment

Christopher W. Seymour et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2015)

Add to Collection
Article Biochemical Research Methods

On-chip surface acoustic wave lysis and ion-exchange nanomembrane detection of exosomal RNA for pancreatic cancer study and diagnosis

Daniel Taller et al.

LAB ON A CHIP (2015)

Add to Collection
Article Biochemical Research Methods

A microfluidic device for label-free, physical capture of circulating tumor cell clusters

A. Fatih Sarioglu et al.

NATURE METHODS (2015)

Add to Collection
Article Multidisciplinary Sciences

A Microfluidic Platform for Evaluating Neutrophil Chemotaxis Induced by Sputum from COPD Patients

Jiandong Wu et al.

PLOS ONE (2015)

Add to Collection
Article Multidisciplinary Sciences

Acoustic separation of circulating tumor cells

Peng Li et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Add to Collection
Review Chemistry, Analytical

Microfluidics Integrated Biosensors: A Leading Technology towards Lab-on-a-Chip and Sensing Applications

George Luka et al.

SENSORS (2015)

Add to Collection
Review Biotechnology & Applied Microbiology

Central Nervous System and its Disease Models on a Chip

YoonYoung Yi et al.

TRENDS IN BIOTECHNOLOGY (2015)

Add to Collection
Review Cell Biology

3D Cell Culture Systems: Advantages and Applications

Maddaly Ravi et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2015)

Add to Collection
Article Multidisciplinary Sciences

Abraxane, the Nanoparticle Formulation of Paclitaxel Can Induce Drug Resistance by Up-Regulation of P-gp

Minzhi Zhao et al.

PLOS ONE (2015)

Add to Collection
Article Multidisciplinary Sciences

Human 3D vascularized organotypic microfluidic assays to study breast cancer cell extravasation

Jessie S. Jeon et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Add to Collection
Review Chemistry, Physical

Enzyme immobilization by adsorption: a review

Teofil Jesionowski et al.

ADSORPTION-JOURNAL OF THE INTERNATIONAL ADSORPTION SOCIETY (2014)

Add to Collection
Article Engineering, Biomedical

Biomaterials for Tissue Engineering

Esther J. Lee et al.

ANNALS OF BIOMEDICAL ENGINEERING (2014)

Add to Collection
Article Engineering, Biomedical

Non-invasive optical imaging of cathepsin B with activatable fluorogenic nanoprobes in various metastatic models

Ju Hee Ryu et al.

BIOMATERIALS (2014)

Add to Collection
Article Biochemical Research Methods

A microfluidic platform for quantitative analysis of cancer angiogenesis and intravasation

Hyunjae Lee et al.

BIOMICROFLUIDICS (2014)

Add to Collection
Article Biophysics

Autonomous capillary microfluidic system with embedded optics for improved troponin I cardiac biomarker detection

M. I. Mohammed et al.

BIOSENSORS & BIOELECTRONICS (2014)

Add to Collection
Article Engineering, Mechanical

Inducing 3D vortical flow patterns with 2D asymmetric actuation of artificial cilia for high-performance active micromixing

Chia-Yuan Chen et al.

EXPERIMENTS IN FLUIDS (2014)

Add to Collection
Article Biochemical Research Methods

Slanted spiral microfluidics for the ultra-fast, label-free isolation of circulating tumor cells

Majid Ebrahimi Warkiani et al.

LAB ON A CHIP (2014)

Add to Collection
Article Biochemical Research Methods

A 1024-sample serum analyzer chip for cancer diagnostics

Jose L. Garcia-Cordero et al.

LAB ON A CHIP (2014)

Add to Collection
Article Biochemical Research Methods

Continuous-flow microfluidic blood cell sorting for unprocessed whole blood using surfacemicromachined microfiltration membranes

Xiang Li et al.

LAB ON A CHIP (2014)

Add to Collection
Article Pediatrics

Biomaterials for tissue engineering applications

Timothy J. Keane et al.

SEMINARS IN PEDIATRIC SURGERY (2014)

Add to Collection
Article Chemistry, Analytical

Microfluidic Chip with Integrated Electrical Cell-Impedance Sensing for Monitoring Single Cancer Cell Migration in Three-Dimensional Matrixes

Tien Anh Nguyen et al.

ANALYTICAL CHEMISTRY (2013)

Add to Collection
Article Biochemical Research Methods

Microfluidic devices for cell cultivation and proliferation

Masoomeh Tehranirokh et al.

BIOMICROFLUIDICS (2013)

Add to Collection
Review Biochemical Research Methods

Recent developments in microfluidics-based chemotaxis studies

Jiandong Wu et al.

LAB ON A CHIP (2013)

Add to Collection
Article Multidisciplinary Sciences

Cooperative Roles of SDF-1α and EGF Gradients on Tumor Cell Migration Revealed by a Robust 3D Microfluidic Model

Beum Jun Kim et al.

PLOS ONE (2013)

Add to Collection
Article Multidisciplinary Sciences

Understanding the Impact of 2D and 3D Fibroblast Cultures on In Vitro Breast Cancer Models

Kyung Eun Sung et al.

PLOS ONE (2013)

Add to Collection
Article Biochemical Research Methods

A practical guide for the fabrication of microfluidic devices using glass and silicon

Ciprian Iliescu et al.

BIOMICROFLUIDICS (2012)

Add to Collection
Review Biotechnology & Applied Microbiology

Immobilization strategies to develop enzymatic biosensors

Audrey Sassolas et al.

BIOTECHNOLOGY ADVANCES (2012)

Add to Collection
Article Medical Laboratory Technology

Application of Electrochemical Biosensors in Clinical Diagnosis

Rastislav Monosik et al.

JOURNAL OF CLINICAL LABORATORY ANALYSIS (2012)

Add to Collection
Article Multidisciplinary Sciences

Dimensional and temporal controls of three-dimensional cell migration by zyxin and binding partners

Stephanie I. Fraley et al.

NATURE COMMUNICATIONS (2012)

Add to Collection
Article Nanoscience & Nanotechnology

Deterministic separation of cancer cells from blood at 10 mL/min

Kevin Loutherback et al.

AIP ADVANCES (2012)

Add to Collection
Article Engineering, Biomedical

Alginate-folic acid-modified chitosan nanoparticles for photodynamic detection of intestinal neoplasms

Shu-Jyuan Yang et al.

BIOMATERIALS (2011)

Add to Collection
Article Oncology

An RNA aptamer that specifically binds pancreatic adenocarcinoma up-regulated factor inhibits migration and growth of pancreatic cancer cells

Yun-Hee Kim et al.

CANCER LETTERS (2011)

Add to Collection
Article Oncology

Microfluidic-Based Multiplex qRT-PCR Identifies Diagnostic and Prognostic microRNA Signatures in the Sera of Prostate Cancer Patients

Felix Moltzahn et al.

CANCER RESEARCH (2011)

Add to Collection
Review Biochemistry & Molecular Biology

Cancer Invasion and the Microenvironment: Plasticity and Reciprocity

Peter Friedl et al.

CELL (2011)

Add to Collection
Article Cell Biology

Transition to invasion in breast cancer: a microfluidic in vitro model enables examination of spatial and temporal effects

Kyung Eun Sung et al.

INTEGRATIVE BIOLOGY (2011)

Add to Collection
Article Pharmacology & Pharmacy

Innovative strategy for treatment of lung cancer: targeted nanotechnology-based inhalation co-delivery of anticancer drugs and siRNA

Oleh Taratula et al.

JOURNAL OF DRUG TARGETING (2011)

Add to Collection
Article Nanoscience & Nanotechnology

Sedimentation pinched-flow fractionation for size- and density-based particle sorting in microchannels

Tomoki Morijiri et al.

MICROFLUIDICS AND NANOFLUIDICS (2011)

Add to Collection
Article Biochemical Research Methods

Integration of intra- and extravasation in one cell-based microfluidic chip for the study of cancer metastasis

Min Kyeong Shin et al.

LAB ON A CHIP (2011)

Add to Collection
Article Biochemical Research Methods

Microfiltration platform for continuous blood plasma protein extraction from whole blood during cardiac surgery

Kiana Aran et al.

LAB ON A CHIP (2011)

Add to Collection
Article Biochemical Research Methods

Deformability-based cell classification and enrichment using inertial microfluidics

Soojung Claire Hur et al.

LAB ON A CHIP (2011)

Add to Collection
Article Medicine, Research & Experimental

Development of EGFR-Targeted Polymer Blend Nanocarriers for Combination Paclitaxel/Lonidamine Delivery To Treat Multi-Drug Resistance in Human Breast and Ovarian Tumor Cells

Lara Milane et al.

MOLECULAR PHARMACEUTICS (2011)

Add to Collection
Article Multidisciplinary Sciences

Plasma Free Amino Acid Profiling of Five Types of Cancer Patients and Its Application for Early Detection

Yohei Miyagi et al.

PLOS ONE (2011)

Add to Collection
Article Cardiac & Cardiovascular Systems

The Distribution of Fluid Shear Stresses in Capillary Sprouts

Peter C. Stapor et al.

Cardiovascular Engineering and Technology (2011)

Add to Collection
Article Biochemical Research Methods

PLGA micro/nanosphere synthesis by droplet microfluidic solvent evaporation and extraction approaches

Lung-Hsin Hung et al.

LAB ON A CHIP (2010)

Add to Collection
Article Polymer Science

Droplet Microfluidics for Fabrication of Non-Spherical Particles

Ho Cheung Shum et al.

MACROMOLECULAR RAPID COMMUNICATIONS (2010)

Add to Collection
Article Computer Science, Interdisciplinary Applications

Microfluidic cell culture system studies and computational fluid dynamics

Manguo Huang et al.

MATHEMATICAL AND COMPUTER MODELLING (2010)

Add to Collection
Article Chemistry, Analytical

Integrated Microfluidic Electrochemical DNA Sensor

Brian S. Ferguson et al.

ANALYTICAL CHEMISTRY (2009)

Add to Collection
Review Endocrinology & Metabolism

Glucose sensors: a review of current and emerging technology

N. S. Oliver et al.

DIABETIC MEDICINE (2009)

Add to Collection
Article Biochemical Research Methods

Microfluidics for cryopreservation

Young S. Song et al.

LAB ON A CHIP (2009)

Add to Collection
Article Chemistry, Multidisciplinary

Hybrid Nanoimprint-Soft Lithography with Sub-15 nm Resolution

Zhiwei Li et al.

NANO LETTERS (2009)

Add to Collection
Article Physics, Multidisciplinary

Scaling the drop size in coflow experiments

E. Castro-Hernandez et al.

NEW JOURNAL OF PHYSICS (2009)

Add to Collection
Article Biochemical Research Methods

Microchip-based cell analysis and clinical diagnosis system

Kae Sato et al.

LAB ON A CHIP (2008)

Add to Collection
Article Biotechnology & Applied Microbiology

Integrated barcode chips for rapid, multiplexed analysis of proteins in microliter quantities of blood

Rong Fan et al.

NATURE BIOTECHNOLOGY (2008)

Add to Collection
Article Chemistry, Analytical

Microfluidic chip for blood cell separation and collection based on crossflow filtration

Xing Chen et al.

SENSORS AND ACTUATORS B-CHEMICAL (2008)

Add to Collection
Article Multidisciplinary Sciences

Isolation of rare circulating tumour cells in cancer patients by microchip technology

Sunitha Nagrath et al.

NATURE (2007)

Add to Collection
Article Multidisciplinary Sciences

Continuous inertial focusing, ordering, and separation of particles in microchannels

Dino Di Carlo et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Add to Collection
Article Nanoscience & Nanotechnology

Intrinsic peroxidase-like activity of ferromagnetic nanoparticles

Lizeng Gao et al.

NATURE NANOTECHNOLOGY (2007)

Add to Collection
Article Biochemical Research Methods

Membrane microfilter device for selective capture, electrolysis and genomic analysis of human circulating tumor cells

Siyang Zheng et al.

JOURNAL OF CHROMATOGRAPHY A (2007)

Add to Collection
Article Chemistry, Analytical

Aptamer-based biosensors for label-free voltammetric detection of lysozyme

Alan K. H. Cheng et al.

ANALYTICAL CHEMISTRY (2007)

Add to Collection
Article Polymer Science

Exploring microfluidic routes to microgels of biological polymers

Hong Zhang et al.

MACROMOLECULAR RAPID COMMUNICATIONS (2007)

Add to Collection
Review Biochemistry & Molecular Biology

Applications of microfluidics in chemical biology

Douglas B. Weibel et al.

CURRENT OPINION IN CHEMICAL BIOLOGY (2006)

Add to Collection
Article Chemistry, Multidisciplinary

Microfluidic production of biopolymer microcapsules with controlled morphology

Hong Zhang et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2006)

Add to Collection
Article Biochemical Research Methods

Continuous separation of particles using a microfluidic device equipped with flow rate control valves

Yuushi Sai et al.

JOURNAL OF CHROMATOGRAPHY A (2006)

Add to Collection
Article Multidisciplinary Sciences

Migration of tumor cells in 3D matrices is governed by matrix stiffness along with cell-matrix adhesion and proteolysis

Muhammad H. Zaman et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Add to Collection
Review Biochemistry & Molecular Biology

Microfluidics-based systems biology

DN Breslauer et al.

MOLECULAR BIOSYSTEMS (2006)

Add to Collection
Article Chemistry, Multidisciplinary

Continuous microfluidic reactors for polymer particles

M Seo et al.

LANGMUIR (2005)

Add to Collection
Article Biochemical Research Methods

Continuous particle separation in a microchannel having asymmetrically arranged multiple branches

J Takagi et al.

LAB ON A CHIP (2005)

Add to Collection
Article Biochemical Research Methods

Isolation of plasma from whole blood using planar microfilters for lab-on-a-chip applications

TA Crowley et al.

LAB ON A CHIP (2005)

Add to Collection
Article Chemistry, Analytical

Pinched flow fractionation: Continuous size separation of particles utilizing a laminar flow profile in a pinched microchannel

M Yamada et al.

ANALYTICAL CHEMISTRY (2004)

Add to Collection
Article Chemistry, Multidisciplinary

A new synthetic method for controlled polymerization using a microfluidic system

T Wu et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2004)

Add to Collection
Article Multidisciplinary Sciences

Microfluidic systems for chemical kinetics that rely on chaotic mixing in droplets

MR Bringer et al.

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES (2004)

Add to Collection
Article Multidisciplinary Sciences

Continuous particle separation through deterministic lateral displacement

LR Huang et al.

SCIENCE (2004)

Add to Collection
Article Multidisciplinary Sciences

Using selective withdrawal to coat microparticles

I Cohen et al.

SCIENCE (2001)

Add to Collection
Article Biophysics

Recombinant antibodies: a new reagent for biological agent detection

PA Emanuel et al.

BIOSENSORS & BIOELECTRONICS (2000)

Add to Collection
Webinars Posters Questions Hubs Funding Journals Papers Connect Collections Reviewers About Us FAQs Mobile App Privacy Policy Terms of Use
© Peeref 2019-2024. All rights reserved.