4.7 Article

Organotin Antifouling Compounds and Sex-Steroid Nuclear Receptor Perturbation: Some Structural Insights

Related references

Note: Only part of the references are listed.
Review Toxicology

Tributyltin and the Female Hypothalamic-Pituitary-Gonadal Disruption

Kayke L. Barbosa et al.

Summary: The HPG axis is crucial for reproductive function control, and exposure to TBT can lead to toxicity in the female reproductive axis components, affecting hypothalamic GnRH expression, folliculogenesis, steroidogenesis, and ovulation. Further research is needed to understand the mechanisms underlying the impairment caused by TBT in the HPG axis.

TOXICOLOGICAL SCIENCES (2022)

Article Biochemistry & Molecular Biology

Subacute and low-dose tributyltin exposure disturbs the mammalian hypothalamus-pituitary-thyroid axis in a sex-dependent manner

Paula Rodrigues-Pereira et al.

Summary: TBT, an endocrine disruptor, has subacute effects on the HPT axis in male and female rats. TBT exposure leads to thyroid alterations and different toxicological effects in male and female rats.

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY (2022)

Article Environmental Sciences

An introduction to the sources, fate, occurrence and effects of endocrine disrupting chemicals released into the environment

C. D. Metcalfe et al.

Summary: This article discusses the sources and fate of selected endocrine disrupting chemicals (EDCs) in the environment. It focuses on the classes of compounds that disrupt the endocrine system of vertebrate and invertebrate organisms. The article highlights the fate of EDCs in environmental media where there is a clear link between exposure and endocrine effects in humans or other taxa.

ENVIRONMENTAL RESEARCH (2022)

Article Environmental Sciences

Triphenyltin disrupts the testicular microenvironment and reduces sperm quality in adult male rats

Mengxi Lu et al.

Summary: The objective of this study was to investigate the effects of Triphenyltin (TPT) on the testicular microenvironment and sperm quality in male rats. The results showed that TPT dose-dependently decreased sperm count and motility, interfered with sperm histone-protamine replacement process, and significantly increased sperm deformity rate. TPT also affected the gene and protein expressions of testis cells and altered the testicular microenvironment. In cell experiments, TPT-treated cells showed negative effects on GC-1 cells.

CHEMOSPHERE (2022)

Review Environmental Sciences

The ecotoxicology of marine tributyltin (TBT) hotspots: A review

Jonny Beyer et al.

Summary: This article reviews the history and current status of tributyltin (TBT) pollution and marine TBT hotspots, with a focus on the Norwegian coastline. It also highlights the toxicity of TBT in various marine species and humans, emphasizing the current understanding of toxicity mechanisms causing endocrine disruption in marine species. Despite the decrease in TBT sediment concentrations in many marine environments, contaminant hotspots are still prevalent globally.

MARINE ENVIRONMENTAL RESEARCH (2022)

Article Developmental Biology

Tributyltin chloride exposure to post-ejaculatory sperm reduces motility, mitochondrial function and subsequent embryo development

Bradford W. Daigneault et al.

Summary: Exposure to environmental organotin can negatively affect post-ejaculatory sperm, leading to decreased sperm motility, lower mitochondrial membrane potential, and reduced embryo development through paternal origin mechanisms.

REPRODUCTION FERTILITY AND DEVELOPMENT (2022)

Article Reproductive Biology

Tributyltin inhibits development of pubertal Leydig cells in rats

Xiande Huang et al.

Summary: This study found that TBT inhibits the development of Leydig cells and reduces androgen production. Both in vivo and in vitro experiments showed that TBT downregulates the expression of genes involved in steroidogenesis and decreases protein levels.

REPRODUCTIVE TOXICOLOGY (2022)

Article Environmental Sciences

Potential Disruption of Systemic Hormone Transport by Tobacco Alkaloids Using Computational Approaches

Mohd Rehan et al.

Summary: Tobacco/nicotine poses a significant threat to global public health and has harmful effects on various systems of the human body. This study found that nicotine and its metabolites can interfere with the binding of carrier proteins and hormones, leading to an imbalance in hormone transport and homeostasis in the blood circulation.

TOXICS (2022)

Article Biology

Mechanistic Insight into the Enzymatic Inhibition of β-Amyrin against Mycobacterial Rv1636: In Silico and In Vitro Approaches

Md Amjad Beg et al.

Summary: This study identifies a significant binding between beta-Amyrin and the universal stress protein Rv1636, which inhibits Rv1636's ATPase activity. This suggests that beta-Amyrin may impair the functioning of Rv1636 and make the bacterium more vulnerable to different stress conditions.

BIOLOGY-BASEL (2022)

Review Environmental Sciences

Review on endocrine disrupting toxicity of triphenyltin from the perspective of species evolution: Aquatic, amphibious and mammalian

Shuwen He et al.

Summary: Triphenyltin is widely used in plastic stabilizers, insecticides, and antifouling coatings. It can induce morphological and physiological changes in the animal endocrine system, especially in the neurological and reproductive regulation. Research has shown that TPT affects the potential health risks of 25 species of animals, with effects related to exposure dose, time, age, sex, and exposed tissue/cells.

CHEMOSPHERE (2021)

Article Food Science & Technology

Potent inhibition of tributyltin (TBT) and triphenyltin (TPT) against multiple UDP-glucuronosyltransferases (UGT): A new potential mechanism underlying endocrine disrupting actions

Hui Lv et al.

Summary: The study showed that TBT and TPT are potent inhibitors of UGTs, interfering with glucuronidation of endogenous hormones and potentially causing endocrine disruption.

FOOD AND CHEMICAL TOXICOLOGY (2021)

Article Biochemistry & Molecular Biology

Essential biochemical, biophysical and computational inputs on efficient functioning of Mycobacterium tuberculosis H37Rv FtsY

Shivangi et al.

Summary: This study explores the essential factors affecting the enzymatic activity of FtsY, including its hydrolysis kinetics of GTP, the influence of cations like Mg2+ and Mn2+ on activity, and the structural changes of FtsY in response to ligand binding. Mutational analysis showed that mutations at key residues significantly reduce FtsY's GTPase activity, while MD simulation indicated effective binding and stabilization of FtsY with GTP, GDP and ATP.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

Article Chemistry, Applied

The organotin contaminants in food: Sources and methods for detection: A systematic review and meta-analysis

Parisa Sadighara et al.

Summary: Organotin compounds in low doses have toxic effects and may contaminate food, mainly found in seafood and edible oils, particularly Tributyltin. Studies have shown that the amount of TBT in seafood exceeded the maximum limit, highlighting the need to take measures to prevent organotin compounds from reaching seawater.

FOOD CHEMISTRY-X (2021)

Article Pharmacology & Pharmacy

Dibutyltin (DBT) inhibits in vitro androgen biosynthesis of rat immature Leydig cells

Guoping Li et al.

Summary: The study showed that exposure to DBT in vitro inhibited androgen production in immature Leydig cells by affecting gene expression and enzyme activities. Specifically, DBT was found to directly inhibit the activities of CYP11A1 and 3β-HSD1 enzymes.

TOXICOLOGY (2021)

Article Marine & Freshwater Biology

Tributyltin impaired spermatogenesis and reproductive behavior in male zebrafish

Xue-Rong Lan et al.

AQUATIC TOXICOLOGY (2020)

Article Public, Environmental & Occupational Health

Endocrine disruption: Molecular interactions of environmental bisphenol contaminants with thyroid hormone receptor and thyroxine-binding globulin

Mohd A. Beg et al.

TOXICOLOGY AND INDUSTRIAL HEALTH (2020)

Article Environmental Sciences

Assessment of the organotin pollution in the coastal sediments of the Western Arabian Gulf, Saudi Arabia

Akere Taiwo Hassan et al.

MARINE POLLUTION BULLETIN (2019)

Article Toxicology

The tributyltin leads to obesogenic mammary gland abnormalities in adult female rats

Charles S. da Costa et al.

TOXICOLOGY LETTERS (2019)

Editorial Material Endocrinology & Metabolism

Editorial: Organotins as a Complete Physiologic and Endocrine Disruptor: Role of Disease Development

Jones Bernardes Graceli

FRONTIERS IN ENDOCRINOLOGY (2019)

Review Environmental Sciences

The obesogen tributyltin induces features of polycystic ovary syndrome (PCOS): a review

Eduardo Merlo et al.

JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS (2018)

Review Cell Biology

Frontiers in endocrine disruption: Impacts of organotin on the hypothalamus-pituitary-thyroid axis

Ana Paula Santos-Silva et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2018)

Article Toxicology

The obesogen tributyltin induces abnormal ovarian adipogenesis in adult female rats

Julia F. P. de Araujo et al.

TOXICOLOGY LETTERS (2018)

Review Endocrinology & Metabolism

Organotin Exposure and Vertebrate Reproduction: A Review

Julia Fernandez Punal de Araujo et al.

FRONTIERS IN ENDOCRINOLOGY (2018)

Review Endocrinology & Metabolism

Effect of Organotins on Crustaceans: Update and Perspective

Everton L. Vogt et al.

FRONTIERS IN ENDOCRINOLOGY (2018)

Review Endocrinology & Metabolism

Organotins in Neuronal Damage, Brain Function, and Behavior: A Short Review

Igor Ferraz da Silva et al.

FRONTIERS IN ENDOCRINOLOGY (2018)

Article Environmental Sciences

Long term impact of the endocrine disruptor tributyltin on male fertility following a single acute exposure

Sumonto Mitra et al.

ENVIRONMENTAL TOXICOLOGY (2017)

Article Environmental Sciences

Levels of Organotin Compounds in Selected Fish Species from the Arabian Gulf

Muhammad Waqar Ashraf et al.

BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY (2017)

Article Multidisciplinary Sciences

Assessment of Tributyltin and Triphenyltin Compounds and Their Main Degradation Products in Saudi Coastal waters

Mohsen A. Al-shatri et al.

ARABIAN JOURNAL FOR SCIENCE AND ENGINEERING (2015)

Review Reproductive Biology

Organotins: A review of their reproductive toxicity, biochemistry, and environmental fate

Jones Bernardes Graceli et al.

REPRODUCTIVE TOXICOLOGY (2013)

Article Biotechnology & Applied Microbiology

Organotin Compounds Act as Inhibitor of Transcriptional Activation with Human Estrogen Receptor

Eun-Min Cho et al.

JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY (2012)

Article Environmental Sciences

TRIBUTYLTIN IMPAIRS THE REPRODUCTIVE CYCLE IN FEMALE RATS

Priscila Lang Podratz et al.

JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES (2012)

Article Environmental Sciences

Organotin Compounds, Including Butyltins and Octyltins, in House Dust from Albany, New York, USA

Kurunthachalam Kannan et al.

ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY (2010)

Article Biochemistry & Molecular Biology

Ligand docking and binding site analysis with PyMOL and Autodock/Vina

Daniel Seeliger et al.

JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN (2010)

Article Environmental Sciences

Organotin speciation and tissue distribution in rat dams, fetuses, and neonates following oral administration of tributyltin chloride

Gerard M. Cooke et al.

JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES (2008)

Article Pharmacology & Pharmacy

Reduction of spermatogenesis in mice after tributyltin administration

Yufang Chen et al.

TOXICOLOGY (2008)

Article Endocrinology & Metabolism

Trialkyltin compounds bind retinoid X receptor to alter human placental endocrine functions

T Nakanishi et al.

MOLECULAR ENDOCRINOLOGY (2005)

Article Environmental Sciences

Occurrence of organotin compounds in house dust in Berlin (Germany)

H Fromme et al.

CHEMOSPHERE (2005)

Article Chemistry, Multidisciplinary

UCSF chimera - A visualization system for exploratory research and analysis

EF Pettersen et al.

JOURNAL OF COMPUTATIONAL CHEMISTRY (2004)

Article Chemistry, Medicinal

Comparative evaluation of 11 scoring functions for molecular docking

RX Wang et al.

JOURNAL OF MEDICINAL CHEMISTRY (2003)

Article Biochemistry & Molecular Biology

Dithioerythritol (DTE) prevents inhibitory effects of triphenyltin (TPT) on the key enzymes of the human sex steroid hormone metabolism

S Lo et al.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2003)

Article Biochemistry & Molecular Biology

Steroidogenesis during in vitro maturation of bovine cumulus oocyte complexes and possible effects of tri-butyltin on granulosa cells

A Schoenfelder et al.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2003)

Article Biochemistry & Molecular Biology

Effects of butyltins on human 5α-reductase type 1 and type 2 activity

DD Doering et al.

STEROIDS (2002)

Article Biochemistry & Molecular Biology

Tributyltin or triphenyltin inhibits aromatase activity in the human granulosa-like tumor cell line KGN

M Saitoh et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2001)

Article Biochemistry & Molecular Biology

Inhibition of human cytochrome P450 aromatase activity by butyltins

DD Heidrich et al.

STEROIDS (2001)

Review Geochemistry & Geophysics

Organotin compounds in the environment - an overview

M Hoch

APPLIED GEOCHEMISTRY (2001)

Article Biochemistry & Molecular Biology

DOCK 4.0: Search strategies for automated molecular docking of flexible molecule databases

TJA Ewing et al.

JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN (2001)