Journal
FRONTIERS IN NUTRITION
Volume 9, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fnut.2022.1053348
Keywords
sciadonic acid; type 2 diabetes mellitus; insulin signaling pathway; gut microbiota; short-chain fatty acids
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Funding
- Foundation of the Key Research and Development Program of Zhejiang Province [2021C02002]
- Key Laboratory of Cancer Prevention and Therapy Combining Traditional Chinese and Western Medicine of Zhejiang Province [202208CL]
- Demonstration and Promotion Project of New Scientific and Technological Achievements of Zhejiang Academy of Agricultural Sciences [tg2022011]
- Project of Science and Technology Program of Quzhou [2021K34]
- Development of deep-processed products of Torreya and evaluation of functional active substances [2021R06B88D02]
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The study found that sciadonic acid (SA) could improve metabolic disorders and intestinal flora imbalance in patients with type 2 diabetes mellitus (T2DM), potentially by activating the PI3K/AKT/GLUT2 pathway, promoting glucose metabolism gene expression, and maintaining the stability of the intestinal flora.
Type 2 diabetes mellitus (T2DM) is a metabolic disease characterized by hyperglycemia. The aim of this work was to investigate the effect of sciadonic acid (SA) on disorders of glucolipid metabolism and intestinal flora imbalance and to further investigate its potential molecular mechanism of anti-diabetes. The experimental data indicated that SA could alleviate hyperlipidemia, insulin resistance, oxidative stress, the inflammatory response, repair liver function damage, and promote glycogen synthesis caused by T2DM. SA could also activate the PI3K/AKT/GLUT-2 signaling pathway, promote glucose metabolism gene expression, and maintain glucose homeostasis. Furthermore, 16S rRNA analysis revealed that SA could reduce the Firmicutes/Bacteroidota (F/B) ratio; promote norank_f__Muribaculaceae, Allobaculum, Akkermansia, and Eubacterium_siraeum_group proliferation; increase the levels of major short-chain fatty acids (SCFAs), such as acetic acid, propionic acid, and butyric acid; and maintain the homeostasis of the intestinal flora. In conclusion, these results suggested that SA could reshape the structural composition of intestinal microbes, activate the PI3K/AKT/GLUT2 pathway, improve insulin resistance, and decrease blood glucose levels.
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