Emerging roles of selenium on metabolism and type 2 diabetes

Selenium is recognized as an essential element for human health and enters human body mainly via diet. Selenium is a key constituent in selenoproteins, which exert essential biological functions, including antioxidant and anti-inflammatory effects. Several selenoproteins including glutathione peroxidases, selenoprotein P and selenoprotein S are known to play roles in the regulation of type 2 diabetes. Although there is a close association between certain selenoproteins with glucose metabolism or insulin resistance, the relationship between selenium and type 2 diabetes is complex and remains uncertain. Here we review recent advances in the field with an emphasis on roles of selenium on metabolism and type 2 diabetes. Understanding the association between selenium and type 2 diabetes is important for developing clinical practice guidelines, establishing and implementing effective public health policies, and ultimately combating relative health issues.

Automated summary

Selenium is an essential element for human health and mainly enters the body through diet. It plays a key role in selenoproteins, which have important biological functions including antioxidant and anti-inflammatory effects. Some selenoproteins are known to be involved in the regulation of type 2 diabetes. However, the relationship between selenium and type 2 diabetes is complex and still uncertain.