Unveiling electrocatalytic performance of MnCo-P on sulfur-doped reduced graphene oxide for electrochemical detection of acetaminophen

It is well known that the overdose and prolonged use of acetaminophen (AAP) drugs could cause severe health issues for human beings. In order to prevent such health issues, it is important to electrochemically monitor the level of AAP in the human body and consumption sources such as river and lake water. In this study, we have developed an electrode modified with manganese cobalt phosphide (MnCo-P) onto sulfur-doped reduced graphene oxide (S-RGO) composite for electrochemical detection of AAP. The cyclic voltammetry analysis shows that the synergistic activity of MnCo-P and S-RGO in the MnCo-P/S-RGO composite obtained a high current responsibility towards the electrochemical detection of AAP. Further, the amperometry (i-t) analysis of MnCo-P/S-RGO for AAP demonstrated a low detection limit of 1.39 nM in the linear range of 0.05 to 1.94 mu M and a sensitivity of 0.658 mu A mu M(-1)cm(-2) which are appreciable. The real sample analysis recovery (%) from AAP detection in tablet, human urine, and river water samples indicates the MnCo-P/S-RGO modified electrode is significant for AAP level monitor in clinical.

Automated summary

It is crucial to monitor the level of AAP in the human body and consumption sources to prevent severe health issues caused by overdose and prolonged use of acetaminophen drugs. In this study, a manganese cobalt phosphide (MnCo-P) modified electrode on sulfur-doped reduced graphene oxide (S-RGO) composite was developed for electrochemical detection of AAP. The results showed high sensitivity and low detection limit of the MnCo-P/S-RGO electrode, making it significant for AAP level monitor in clinical settings.