Eating, diet, and nutrition for the treatment of non-alcoholic fatty liver disease

Nutrition and dietary interventions are a central component in the pathophysiology, but also a cornerstone in the management of patients with non-alcoholic fatty liver disease (NAFLD). Summarizing our rapidly advancing understanding of how our diet influences our metabolism and focusing on specific effects on the liver, we provide a comprehensive overview of dietary concepts to counteract the increasing burden of NAFLD. Specifically, we emphasize the importance of dietary calorie restriction independently of the macronutrient composition together with adherence to a Mediterranean diet low in added fructose and processed meat that seems to exert favorable effects beyond calorie restriction. Also, we discuss intermittent fasting as a type of diet specifically tailored to decrease liver fat content and increase ketogenesis, awaiting future study results in NAFLD. Finally, personalized dietary recommendations could be powerful tools to increase the effectiveness of dietary interventions in patients with NAFLD considering the genetic background and the microbiome, among others.

Automated summary

Nutrition and dietary interventions play a central role in the pathophysiology and management of NAFLD. Calorie restriction, adherence to a Mediterranean diet and intermittent fasting show promising effects in reducing liver fat content. Personalized dietary recommendations considering genetic background and microbiome could further enhance the effectiveness of interventions.