Journal
COMMUNICATIONS BIOLOGY
Volume 5, Issue 1, Pages -Publisher
NATURE PORTFOLIO
DOI: 10.1038/s42003-022-04328-2
Keywords
-
Categories
Funding
- European Commission [317304, NMP-2014-646075, PITN-GA-2012-317304]
- Science Foundation Ireland (SFI) [13/RC/2073_P2]
- Irish Government's Programme for Research in Third Level Institutions, Cycles 4, National Development Plan 2007-2013
- Irish Government's Programme for Research in Third Level Institutions, Cycles 5, National Development Plan 2007-2013
Ask authors/readers for more resources
By using transcriptomic, proteomic, and glycomic approaches, this study identifies metabolic reprogramming and glycan structural remodeling as potential drivers of tissue regeneration in the zebrafish heart after injury.
The ability of the zebrafish heart to regenerate following injury makes it a valuable model to deduce why this capability in mammals is limited to early neonatal stages. Although metabolic reprogramming and glycosylation remodeling have emerged as key aspects in many biological processes, how they may trigger a cardiac regenerative response in zebrafish is still a crucial question. Here, by using an up-to-date panel of transcriptomic, proteomic and glycomic approaches, we identify a metabolic switch from mitochondrial oxidative phosphorylation to glycolysis associated with membrane glycosylation remodeling during heart regeneration. Importantly, we establish the N- and O-linked glycan structural repertoire of the regenerating zebrafish heart, and link alterations in both sialylation and high mannose structures across the phases of regeneration. Our results show that metabolic reprogramming and glycan structural remodeling are potential drivers of tissue regeneration after cardiac injury, providing the biological rationale to develop novel therapeutics to elicit heart regeneration in mammals.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available