Adverse maternal, fetal, and newborn outcomes among pregnant women with SARS-CoV-2 infection: an individual participant data meta-analysis

Article Obstetrics & Gynecology

SARS-CoV-2 and pregnancy outcomes under universal and non-universal testing in Sweden: register-based nationwide cohort study

O. Stephansson et al.

Summary: This study assessed the association between SARS-CoV-2 infection and pregnancy outcomes, showing that testing policy and timing of test-positivity impact the associations between them.

BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY (2022)

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Article Acoustics

Increased levels of soluble fms-like tyrosine kinase-1 are associated with adverse outcome in pregnant women with COVID-19

J. Torres-Torres et al.

Summary: In addition to the lungs, the placenta and endothelium can be affected by SARS-CoV-2. High sFlt-1 levels are associated with severe COVID-19 in pregnant women and can predict severe adverse pregnancy events such as pneumonia, ICU admission, viral sepsis, and maternal death.

ULTRASOUND IN OBSTETRICS & GYNECOLOGY (2022)

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Article Obstetrics & Gynecology

Epidemiology of coronavirus disease 2019 in pregnancy: risk factors and associations with adverse maternal and neonatal outcomes

Justin S. Brandt et al.

Summary: This study aimed to quantify the associations of coronavirus disease 2019 with adverse maternal and neonatal outcomes in pregnancy, showing that the disease is associated with an increased risk of adverse maternal and neonatal outcomes, primarily driven by morbidity associated with severe or critical coronavirus disease 2019. Major risk factors for associated morbidity were identified as black and Hispanic race, obesity, advanced maternal age, medical comorbidities, and antepartum admissions related to coronavirus disease 2019.

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2021)

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Letter Obstetrics & Gynecology

Is COVID-19 a risk factor for severe preeclampsia? Hospital experience in a developing country

Julia Cristina Coronado-Arroyo et al.

EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY (2021)

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Article Obstetrics & Gynecology

Maternal and perinatal outcomes of pregnant women with SARS-CoV-2 infection at the time of birth in England: national cohort study

Ipek Gurol-Urganci et al.

Summary: This study found that SARS-CoV-2 infection at the time of birth is associated with higher rates of adverse maternal and perinatal outcomes, including fetal death, preterm birth, preeclampsia, and emergency cesarean delivery. Pregnant women infected with SARS-CoV-2 should be prioritized for vaccination to reduce these risks.

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2021)

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Article Immunology

Impact of Severe Acute Respiratory Syndrome Coronavirus 2 Infection on Pregnancy Outcomes: A Population-based Study

Francesca Crovetto et al.

Summary: This study found that pregnancy complications in women with SARS-CoV-2 infection were similar to those of noninfected women overall, but symptomatic COVID-19 was associated with modest increases in preterm delivery and intrapartum fetal distress.

CLINICAL INFECTIOUS DISEASES (2021)

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Article Obstetrics & Gynecology

Disease Severity and Perinatal Outcomes of Pregnant Patients With Coronavirus Disease 2019 (COVID-19)

Torri D. Metz et al.

Summary: This study found that pregnant patients with severe-critical COVID-19, but not those with mild-moderate COVID-19, were at increased risk of perinatal complications compared to those without symptoms.

OBSTETRICS AND GYNECOLOGY (2021)

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Article Virology

Novel Ratio Soluble Fms-like Tyrosine Kinase-1/Angiotensin-II (sFlt-1/ANG-II) in Pregnant Women Is Associated with Critical Illness in COVID-19

Salvador Espino-Y-Sosa et al.

Summary: The sFlt-1/ANG-II ratio is associated with an increased probability of severe pneumonia, ICU admission, intubation, sepsis, and death in pregnant women with COVID-19.

VIRUSES-BASEL (2021)

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Article Medicine, General & Internal

The impact of COVID-19 on pregnancy outcomes: a systematic review and meta-analysis

Shu Qin Wei et al.

Summary: Infection with COVID-19 during pregnancy may lead to an increased risk of preeclampsia, preterm birth, and other adverse pregnancy outcomes. Severe cases of COVID-19 are particularly associated with higher risks of complications such as preeclampsia, preterm birth, gestational diabetes, and low birth weight.

CANADIAN MEDICAL ASSOCIATION JOURNAL (2021)

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Article Public, Environmental & Occupational Health

Risk for Stillbirth Among Women With and Without COVID-19 at Delivery Hospitalization — United States, March 2020–September 2021

Carla L. DeSisto et al.

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT (2021)

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Article Multidisciplinary Sciences

The incidence, characteristics and outcomes of pregnant women hospitalized with symptomatic and asymptomatic SARS-CoV-2 infection in the UK from March to September 2020: A national cohort study using the UK Obstetric Surveillance System (UKOSS)

Nicola Vousden et al.

Summary: The study identified factors that increase the risk of symptomatic and asymptomatic SARS-CoV-2 infection in pregnancy. Clinicians can be reassured that the majority of women do not experience severe complications of SARS-CoV-2 in pregnancy. Cesarean birth rates and neonatal unit admission rates were increased for pregnant women with symptomatic and asymptomatic SARS-CoV-2. The risks of stillbirth or neonatal death were not significantly increased.

PLOS ONE (2021)

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Article Pediatrics

Maternal and Neonatal Morbidity and Mortality Among Pregnant Women With and Without COVID-19 Infection The INTERCOVID Multinational Cohort Study

Jose Villar et al.

Summary: This study evaluated the risks associated with COVID-19 in pregnancy on maternal and neonatal outcomes compared with pregnant individuals without COVID-19, finding that pregnant individuals with COVID-19 were at higher risk for various complications such as preeclampsia, severe infections, and preterm birth. The findings emphasize the importance for pregnant individuals and clinicians to strictly implement recommended COVID-19 preventive measures.

JAMA PEDIATRICS (2021)

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Letter Obstetrics & Gynecology

Misclassification bias and unnecessary anxiety

Marian Knight et al.

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2021)

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Article Medicine, General & Internal

Characteristics and Outcomes of Women With COVID-19 Giving Birth at US Academic Centers During the COVID-19 Pandemic

Justine Chinn et al.

Summary: This study compared characteristics and outcomes of women who underwent childbirth with vs without COVID-19 in a large US cohort, and found that women with COVID-19 during childbirth had higher rates of mortality, intubation, ICU admission, and preterm birth.

JAMA NETWORK OPEN (2021)

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Letter Obstetrics & Gynecology