4.6 Article

Sodium Danshensu Cream Promotes the Healing of Pressure Ulcers in Mice through the Nrf2/HO-1 and NF-κB Pathways

Journal

PHARMACEUTICALS
Volume 15, Issue 12, Pages -

Publisher

MDPI
DOI: 10.3390/ph15121548

Keywords

pressure ulcers; sodium Danshensu cream; ischemia /reperfusion injury; Nrf2/HO-1 pathway; NF-kappa B pathway

Funding

  1. Health Commission of Zhejiang Province
  2. Zhejiang Medical Health Science and Technology Program
  3. Hangzhou Health Science and Technology Project
  4. [2019KY470]
  5. [2022RC062]
  6. [A20210366]

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Based on a mice pressure ulcers (PU) model, this study investigated the protective effect and potential mechanism of sodium Danshensu (SDSS) cream against PU. The results showed that SDSS cream promoted wound healing and regulated inflammatory factors and oxidative stress markers in the serum. Additionally, SDSS cream exerted its protective effect by modulating the Nrf2/HO-1 and NF-kappa B pathways.
On the basis of the mice pressure ulcers (PU) model, the protective effect and potential mechanism of sodium Danshensu (SDSS) cream against PU were investigated. The mice were randomly divided into three groups: the negative control group (cream without 0.5 g SDSS), the SDSS group (cream containing 0.5 g SDSS), and the positive group (0.5 g Hirudoid (R)). After 7 and 14 days of ointment application, the wound-healing rate of the SDSS and positive groups was significantly higher than that of the control group (p < 0.05). The results of hematoxylin-eosin staining also indicated that SDSS has the potential to promote the healing of PU. In addition, the serum IL-6, IL-1 beta, TNF-alpha, and MDA levels decreased significantly (p < 0.01) after 14 days of SDSS treatment, while the SOD, CAT, and GSH-Px activities increased significantly (p < 0.01). In addition, SDSS cream was able to significantly increase the expression of Nrf2, HO-1, GCLM, NQO1, NF-kappa B p65, NF-kappa B p50, IKK alpha, and IKK beta while decreasing the expression of Keap1 and I kappa B alpha in the Nrf2/HO-1 and NF-kappa B pathways. Our research will provide a foundation for the future clinical prevention and treatment of PU with SDSS cream.

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