Components with Anti-Diabetic Activity Isolated from the Leaves and Twigs of Glycosmis pentaphylla Collected in Vietnam

A phytochemical investigation of the leaves and twigs of Glycosmis pentaphylla (Rutaceae), collected in Vietnam, yielded three new compounds named glyfuran (1), glyphyllamide (2), and glyphyllazole (3), along with twenty-five known compounds (4-28). The structures of isolates were determined by IR, MS, NMR, and UV data analyses. In the anti-diabetic activity screening, (+)-isoaltholacton (4), glycoborinine (17), 2 ',4 '-dihydroxy-4,6 '-dimethoxychalcone (24), and flavokawain A (25) simultaneously exhibited inhibition of dipeptidyl peptidase-4 (DPP4) and stimulation of the glucagon-like peptide-1 (GLP-1) secretion on the murine intestinal secretin tumor cell line (STC-1).

Automated summary

A phytochemical investigation of Glycosmis pentaphylla collected in Vietnam resulted in the discovery of three new compounds and twenty-five known compounds. The structures of the isolates were determined through various analytical methods. In the screening for anti-diabetic activity, several compounds showed potential inhibition of DPP4 and stimulation of GLP-1 secretion.