The Use of Calcium Phosphate-Based Starter Pellets for the Preparation of Sprinkle IR MUPS Formulation of Rosuvastatin Calcium

Article Pharmacology & Pharmacy

Directly compressible formulation of immediate release rosuvastatin calcium tablets stabilized with tribasic calcium phosphate

Daniel Zakowiecki et al.

Summary: Reliable and stable tablet formulations for rosuvastatin calcium have been developed, providing good mechanical properties, rapid disintegration, and dissolution rate, as well as satisfactory chemical stability.

PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY (2022)

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Article Engineering, Chemical

Different trends for preparation of budesonide pellets with enhanced dissolution rate

Fatemeh Soltani et al.

Summary: The current research explores different approaches to improve the dissolution rate of budesonide in pellet formulations. The method of layering budesonide solid dispersion on placebo pellets (LSDP) shows the most promising results for achieving high dissolution rate.

ADVANCED POWDER TECHNOLOGY (2022)

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Review Pharmacology & Pharmacy

Review on Starter Pellets: Inert and Functional Cores

Nikolett Kallai-Szabo et al.

Summary: A significant proportion of pharmaceuticals are now considered multiparticulate systems, and patient-centric dosing can be easily achieved using multi-unit systems. This article presents commonly used starter pellets and discusses the properties of various cores, as well as the drug release mechanism of layered pellets formed based on different inert cores.

PHARMACEUTICS (2022)

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Review Pharmacology & Pharmacy

A Comprehensive Review on Pellets as a Dosage Form in Pharmaceuticals

Maithri S. Handattu et al.

Summary: Oral administration using solid dosage forms, particularly multiple-unit dosage forms, is preferred due to its ability to evenly distribute the drug in the gastrointestinal tract.

CURRENT DRUG TARGETS (2021)

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Article Medicine, General & Internal

A Difficult Pill to Swallow: An Investigation of the Factors Associated with Medication Swallowing Difficulties

Chandramouli Radhakrishnan et al.

Summary: The study identified factors such as smaller oral cavity size, higher density of taste receptors on the tongue, and previous choking episodes on medications as contributing to medication swallowing difficulties among healthy adults. These factors could help in identifying individuals who are more likely to experience problems with swallowing medications.

PATIENT PREFERENCE AND ADHERENCE (2021)

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Article Chemistry, Multidisciplinary

Taste Masking Study Based on an Electronic Tongue: the Formulation Design of 3D Printed Levetiracetam Instant-Dissolving Tablets

Zengming Wang et al.

Summary: Proper taste-masking formulation design is crucial for instant-dissolving tablets (IDTs). This study utilized the electronic tongue to design additives for 3D printed IDTs, resulting in some additives effectively masking bitterness and resembling placebo taste. Human gustatory sensation tests were consistent with the trend of electronic tongue evaluation.

PHARMACEUTICAL RESEARCH (2021)

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Review Cardiac & Cardiovascular Systems

Hydrophilic or Lipophilic Statins?

Elisenda Climent et al.

Summary: Statins can be classified as hydrophilic or lipophilic, with different solubility profiles potentially impacting cardiovascular outcomes and adverse effects. The superiority of one type of statin over another in terms of solubility remains uncertain, with conflicting results observed in previous studies on cardiovascular and heart failure outcomes.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2021)

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Article Pharmacology & Pharmacy

Development of a Biphasic-Release Multiple-Unit Pellet System with Diclofenac Sodium Using Novel Calcium Phosphate-Based Starter Pellets

Daniel Zakowiecki et al.

Summary: The study used novel calcium phosphate-based starter pellets to develop a biphasic-release multiple-unit pellet system containing drug-layered pellets with delayed-release and extended-release characteristics. Comparative dissolution testing showed similar results to an equivalent commercial product prepared using direct pelletization technique.

PHARMACEUTICS (2021)

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Review Pharmacology & Pharmacy