Journal
PHARMACEUTICALS
Volume 15, Issue 12, Pages -Publisher
MDPI
DOI: 10.3390/ph15121498
Keywords
Gram-negative bacteria; antimicrobial resistance; CRISPR-Cas system; CRISPRi
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Funding
- Sir H.N. Medical Research Society
- Sir H.N. Reliance Foundation Hospital & Research Centre, Mumbai, Maharashtra, India
- [HNH/IEC/2022/OCS/PHD/99]
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This article discusses the pathogenesis of Gram-negative bacteria, the emergence of antimicrobial drug resistance, treatment failures, and the current status of the CRISPR-Cas system in diagnosing and treating Gram-negative bacterial infections.
Rapidly emerging drug-resistant superbugs, especially Gram-negative bacteria, pose a serious threat to healthcare systems all over the globe. Newer strategies are being developed to detect and overcome the arsenal of weapons that these bacteria possess. The development of antibiotics is time-consuming and may not provide full proof of action on evolving drug-resistant pathogens. The clustered regularly interspaced short palindromic repeats/CRISPR-associated protein (CRISPR/Cas) systems are promising in curbing drug-resistant bacteria. This review focuses on the pathogenesis of Gram-negative bacteria, emergence of antimicrobial drug resistance, and their treatment failures. It also draws attention to the present status of the CRISPR-Cas system in diagnosisand treatment of Gram-negative bacterial infections.
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