Three-Dimensional Accuracy and Stability of Personalized Implants in Orthognathic Surgery: A Systematic Review and a Meta-Analysis

This systematic review aimed to determine the accuracy/stability of patient-specific osteosynthesis (PSI) in orthognathic surgery according to three-dimensional (3D) outcome analysis and in comparison to conventional osteosynthesis and computer-aided designed and manufactured (CAD/CAM) splints or wafers. The PRISMA guidelines were followed and six academic databases and Google Scholar were searched. Records reporting 3D accuracy/stability measurements of bony segments fixated with PSI were included. Of 485 initial records, 21 met the eligibility (566 subjects), nine of which also qualified for a meta-analysis (164 subjects). Six studies had a high risk of bias (29%), and the rest were of low or moderate risk. Procedures comprised either single-piece or segmental Le Fort I and/or mandibular osteotomy and/or genioplasty. A stratified meta-analysis including 115 subjects with single-piece Le Fort I PSI showed that the largest absolute mean deviations were 0.5 mm antero-posteriorly and 0.65 degrees in pitch. PSIs were up to 0.85 mm and 2.35 degrees more accurate than conventional osteosynthesis with CAD/CAM splint or wafer (p < 0.0001). However, the clinical relevance of the improved accuracy has not been shown. The literature on PSI for multi-piece Le Fort I, mandibular osteotomies and genioplasty procedure is characterized by high methodological heterogeneity and a lack of randomized controlled trials. The literature is lacking on the 3D stability of bony segments fixated with PSI.

Automated summary

This systematic review examined the accuracy and stability of patient-specific osteosynthesis (PSI) in orthognathic surgery using three-dimensional outcome analysis. It compared PSI to conventional osteosynthesis and computer-aided designed and manufactured splints or wafers. The results showed that PSI was more accurate than conventional osteosynthesis with CAD/CAM splint or wafer. However, the clinical significance of the improved accuracy has not been confirmed. The literature on multi-piece Le Fort I, mandibular osteotomies, and genioplasty procedure using PSI is limited and lacks randomized controlled trials.