A Systematic Review of Chest Imaging Findings in Long COVID Patients

Long COVID is the persistence of one or more COVID-19 symptoms after the initial viral infection, and there is evidence supporting its association with lung damage. In this systematic review, we provide an overview of lung imaging and its findings in long COVID patients. A PubMed search was performed on 29 September 2021, for English language studies in which lung imaging was performed in adults suffering from long COVID. Two independent researchers extracted the data. Our search identified 3130 articles, of which 31, representing the imaging findings of 342 long COVID patients, were retained. The most common imaging modality used was computed tomography (CT) (N = 249). A total of 29 different imaging findings were reported, which were broadly categorized into interstitial (fibrotic), pleural, airway, and other parenchymal abnormalities. A direct comparison between cases, in terms of residual lesions, was available for 148 patients, of whom 66 (44.6%) had normal CT findings. Although respiratory symptoms belong to the most common symptoms in long COVID patients, this is not necessarily linked to radiologically detectable lung damage. Therefore, more research is needed on the role of the various types of lung (and other organ) damage which may or may not occur in long COVID.

Automated summary

Long COVID refers to the persistence of COVID-19 symptoms after the initial infection, and it is associated with lung damage. This systematic review focuses on lung imaging and its findings in patients with long COVID. The study identified 31 articles that reported imaging findings of 342 long COVID patients, with computed tomography (CT) being the most common modality used. Various types of lung abnormalities were observed, but a significant proportion of patients had normal CT findings. Further research is needed to understand the role of lung and organ damage in long COVID.