Diagnostic Accuracy of Methods for Detection of Antibodies against Type I Interferons in Patients with Endocrine Disorders

Letter Immunology

Diagnosis of APS-1 in Two Siblings Following Life-Threatening COVID-19 Pneumonia

Laire Schidlowski et al.

JOURNAL OF CLINICAL IMMUNOLOGY (2022)

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Letter Immunology

Low Lymphocytes and IFN-Neutralizing Autoantibodies as Biomarkers of COVID-19 Mortality

Jesus Troya et al.

JOURNAL OF CLINICAL IMMUNOLOGY (2022)

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Review Immunology

Human autoantibodies underlying infectious diseases

Anne Puel et al.

Summary: The vast clinical variability in microbial infections can be explained by human genetic and immunological factors, with autoantibodies playing a role in specific infectious diseases.

JOURNAL OF EXPERIMENTAL MEDICINE (2022)

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Article Immunology

Screening patients with autoimmune endocrine disorders for cytokine autoantibodies reveals monogenic immune deficiencies

Thea Sjogren et al.

Summary: Screening for cytokine autoantibodies can efficiently identify patients with previously unknown monogenic and possible oligogenic causes of autoimmune and immune deficiency diseases, providing crucial information for personalized treatment and follow-up.

JOURNAL OF AUTOIMMUNITY (2022)

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Article Immunology

Auto-antibodies to type I IFNs can underlie adverse reactions to yellow fever live attenuated vaccine

Paul Bastard et al.

Summary: In rare cases, yellow fever virus (YFV) live attenuated vaccine can cause life-threatening disease, particularly in patients with no history of severe viral illness. Some patients with auto-Abs against multiple type I interferons and autosomal recessive IFNAR1 or IFNAR2 deficiency were found to be at risk of developing severe complications after YFV vaccination. Testing for these predispositions could be considered for healthy individuals before YFV vaccination.

JOURNAL OF EXPERIMENTAL MEDICINE (2021)

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Article Biochemistry & Molecular Biology

Multiplex Autoantibody Detection in Patients with Autoimmune Polyglandular Syndromes

Elena N. Savvateeva et al.

Summary: The diagnosis of autoimmune polyglandular syndrome (APS) 1/2 is challenging due to their rarity and non-specific clinical manifestations. A new microarray-based multiplex assay was proposed for simultaneous detection of organ-specific and APS-1-specific autoantibodies. APS-1 patients were characterized by the presence of at least two specific autoantibodies. The accuracy of the multiplex assay compared to ELISA for organ-specific autoantibodies was high.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Immunology

Autoantibodies neutralizing type I IFNs are present in ∼4% of uninfected individuals over 70 years old and account for ∼20% of COVID-19 deaths

Paul Bastard et al.

Summary: Autoantibodies neutralizing interferons are present in a significant percentage of critical COVID-19 patients, especially in older individuals, and their prevalence increases with age.

SCIENCE IMMUNOLOGY (2021)

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Article Multidisciplinary Sciences