Journal
JOURNAL OF PERSONALIZED MEDICINE
Volume 12, Issue 12, Pages -Publisher
MDPI
DOI: 10.3390/jpm12121943
Keywords
genetic testing; genomics; genomic screening; precision health; MyCode; emotional response; psychological impact; patient outcomes
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This study aimed to understand individuals' psychological response to receiving an actionable genetic test result from genomic screening. The results showed that over time, participants' emotional response to receiving the results decreased, with mainly moderate positive emotions. These findings provide support for the clinical utility of population genomic screening programs.
Genomic screening programs have potential to benefit individuals who may not be clinically ascertained, but little is known about the psychological impact of receiving genetic results in this setting. The current study sought to further the understanding of individuals' psychological response to receiving an actionable genetic test result from genomic screening. Telephone surveys were conducted with patient-participants at 6 weeks and 6 months post genetic result disclosure between September 2019 and May 2021 and assessed emotional response to receiving results via the FACToR, PANAS, and decision regret scales. Overall, 354 (29.4%) study participants completed both surveys. Participants reported moderate positive emotions and low levels of negative emotions, uncertainty, privacy concern, and decision regret over time. There were significant decreases in negative emotions (p = 0.0004) and uncertainty (p = 0.0126) between time points on the FACToR scale. Interested was the highest scoring discrete emotion (T1 3.6, T2 3.3, scale 0-5) but was significantly lower at 6 months (<0.0001). Coupled with other benefits of genomic screening, these results of modest psychological impact waning over time adds support to clinical utility of population genomic screening programs. However, questions remain regarding how to elicit an emotional response that motivates behavior change without causing psychological harm.
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