Journal
ISCIENCE
Volume 25, Issue 12, Pages -Publisher
CELL PRESS
DOI: 10.1016/j.isci.2022.105652
Keywords
-
Categories
Funding
- Swedish Research Council [2019- 04663, 2020-03602, 2021-03706]
- Magnus Bergvall Foundation [2019-03436]
- Ake Wiberg Foundation [M19-0559]
- Clas Groschinsky Foundation [M-2049]
- Swedish Medical Association [SLS-934363]
- Heart and Lung Foundation [20180386, 20200194]
- Swedish Research Council [2019-04663, 2020-03602, 2021-03706] Funding Source: Swedish Research Council
- Swedish Heart-Lung Foundation [20180386, 20200194] Funding Source: Swedish Heart-Lung Foundation
Ask authors/readers for more resources
This exploratory study aimed to identify biomarkers associated with active tuberculosis (TB). Through analyzing the plasma levels of inflammation-related proteins, a protein module strongly associated with active TB was identified. A 12-protein plasma signature was derived from the module and was found to be highly enriched in individuals with pulmonary and extrapulmonary TB, and associated with disease severity.
Annually, approximately 10 million people are diagnosed with active tuberculosis (TB), and 1.4 million die of the disease. If left untreated, each person with active TB will infect 10-15 new individuals. The lack of non-sputum-based diagnostic tests leads to delayed diagnoses of active pulmonary TB cases, contributing to continued disease transmission. In this exploratory study, we aimed to identify biomarkers associated with active TB. We assessed the plasma levels of 92 proteins associated with inflammation in individuals with active TB (n = 20), latent TB (n = 14), or healthy controls (n = 10). Using co-expression network analysis, we identified one module of proteins with strong association with active TB. We removed proteins from the module that had low abundance or were associated with non-TB diseases in published transcriptomic datasets, resulting in a 12-protein plasma signature that was highly enriched in individuals with pulmonary and extrapulmonary TB and was further associated with disease severity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available