4.7 Article

Usnic Acid extends healthspan and improves the neurodegeneration diseases via mTOR/PHA-4 signaling pathway in Caenorhabditis elegans

Related references

Note: Only part of the references are listed.
Article Chemistry, Medicinal

Usnic acid suppresses cervical cancer cell proliferation by inhibiting PD-L1 expression and enhancing T-lymphocyte tumor-killing activity

Tong Xin Sun et al.

Summary: In this study, usnic acid was found to decrease PD-L1 expression in tumor cells, enhance T cell cytotoxicity, and inhibit PD-L1 protein synthesis by cooperatively reducing STAT3 and RAS pathways. Additionally, usnic acid induced lysosome biogenesis through mTOR signaling pathway suppression, leading to PD-L1 translocation and subsequent proteolysis in lysosomes. Furthermore, usnic acid inhibited tumor growth by downregulating PD-L1 and affecting cell proliferation, angiogenesis, migration, and invasion processes.

PHYTOTHERAPY RESEARCH (2021)

Review Neurosciences

Mammalian/mechanistic target of rapamycin (mTOR) complexes in neurodegeneration

Henry Querfurth et al.

Summary: mTOR is involved in regulating energy metabolism, neuronal growth, insulin signaling, and autophagy, playing both beneficial and pathogenic roles in neurodegenerative diseases. Balanced actions of mTOR complexes may have implications for Alzheimer's disease, Parkinson's disease, Huntington's disease, Frontotemporal dementia, and Amyotrophic Lateral Sclerosis. Beyond rapamycin, rapalogs with improved tolerability and delivery modes hold promise in treating age-related conditions.

MOLECULAR NEURODEGENERATION (2021)

Review Chemistry, Medicinal

Usnic acid and its derivatives for pharmaceutical use: a patent review (2000-2017)

Olga A. Luzina et al.

EXPERT OPINION ON THERAPEUTIC PATENTS (2018)

Article Medicine, General & Internal

Effect of Usnic Acid on Osteoclastogenic Activity

Kwang-Jin Kim et al.

JOURNAL OF CLINICAL MEDICINE (2018)

Article Cell Biology

Sanguinarine inhibits growth and invasion of gastric cancer cells via regulation of the DUSP4/ERK pathway

Rui Zhang et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2017)

Review Cell Biology

TOR-mediated regulation of metabolism in aging

Henri Antikainen et al.

AGING CELL (2017)

Review Medicine, Research & Experimental

Rapalogs and mTOR inhibitors as anti-aging therapeutics

Dudley W. Lamming et al.

JOURNAL OF CLINICAL INVESTIGATION (2013)

Article Multidisciplinary Sciences

The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans

Louis R. Lapierre et al.

NATURE COMMUNICATIONS (2013)

Article Endocrinology & Metabolism

Neuronal ROS signaling rather than AMPK/sirtuin-mediated energy sensing links dietary restriction to lifespan extension

Sebastian Schmeisser et al.

MOLECULAR METABOLISM (2013)

Article Integrative & Complementary Medicine

Chemical Composition, Antioxidant, and Antimicrobial Activities of Lichen Umbilicaria cylindrica (L.) Delise (Umbilicariaceae)

Nedeljko T. Manojlovic et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2012)

Article Multidisciplinary Sciences

RPN-6 determines C. elegans longevity under proteotoxic stress conditions

David Vilchez et al.

NATURE (2012)

Article Biochemical Research Methods

NIH Image to ImageJ: 25 years of image analysis

Caroline A. Schneider et al.

NATURE METHODS (2012)

Article Multidisciplinary Sciences

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

David E. Harrison et al.

NATURE (2009)

Review Biotechnology & Applied Microbiology

The evolving role of natural products in drug discovery

FE Koehn et al.

NATURE REVIEWS DRUG DISCOVERY (2005)

Article Multidisciplinary Sciences

Measurements of age-related changes of physiological processes that predict lifespan of Caenorhabditis elegans

C Huang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Article Biochemical Research Methods

Genorne-wide RNAi screening in Caenorhabditis elegans

RS Kamath et al.

METHODS (2003)

Article Biochemistry & Molecular Biology

Usnic acid

K Ingólfsdóttir

PHYTOCHEMISTRY (2002)

Article Multidisciplinary Sciences

Regulation of life-span by germ-line stem cells in Caenorhabditis elegans

N Arantes-Oliveira et al.

SCIENCE (2002)

Review Cell Biology

Transgenic invertebrate models of age-associated neurodegenerative diseases

CD Link

MECHANISMS OF AGEING AND DEVELOPMENT (2001)