Journal
BIOMEDICINES
Volume 11, Issue 1, Pages -Publisher
MDPI
DOI: 10.3390/biomedicines11010038
Keywords
prostatic neoplasms; recurrence; lymph nodes; PSMA PET; CT; gallium 68 PSMA-11; prostate cancer; radiation therapy; radiotherapy; pelvic LN
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The main prostate cancer treatments do not eliminate the risk of lymph node metastases. Traditional imaging methods are not sensitive enough for diagnosing lymph node metastases, while the novel PSMA PET/CT scanning provides valuable information for recurrent prostate cancer patients. Its high sensitivity enables accurate N staging in prostate cancer patients.
The main prostate cancer (PCa) treatments include surgery or radiotherapy (with or without ADT). However, none of the suggested treatments eliminates the risk of lymph node metastases. Conventional imaging methods, including MRI and CT scanning, are not sensitive enough for the diagnosis of lymph node metastases; however, the novel imaging method, PSMA PET/CT scanning, has provided valuable information about the pelvic LN involvement in patients with recurrent PCa (RPCa) after radical prostatectomy. The high sensitivity and negative predictive value enable accurate N staging in PCa patients. In this narrative review, we summarize the evidence on the treatment and extent of radiation in prostate-only or whole-pelvis radiation in patients with positive and negative LN involvement on PSMA PET/CT scans.
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