4.7 Review

Opportunities and Challenges of Human IPSC Technology in Kidney Disease Research

Related references

Note: Only part of the references are listed.
Article Cell & Tissue Engineering

SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids

Jitske Jansen et al.

Summary: The study found that SARS-CoV-2 can directly infect kidney cells, leading to cell injury and fibrosis, causing kidney failure. Inhibitors can alleviate the infection.

CELL STEM CELL (2022)

Article Cell Biology

Population-based high-throughput toxicity screen of human iPSC-derived cardiomyocytes and neurons

Ching Ying Huang et al.

Summary: In this study, a population-based hiPSC drug screening platform is established to assess toxicity. Thirteen HLA-homozygous super donors are identified after recruiting 1,000 healthy donors and screening for high-frequency HLA haplotypes, representing at least 477,611,135 of the global population. The differentiated hiPSCs into cardiomyocytes and neurons demonstrate their utility in a high-throughput toxicity screen. Dose-dependent toxicity and functional modulation of hit compounds are validated, and reproducible in vivo drug toxicity results using mouse models are shown. This study shows the feasibility of using a population-based hiPSC drug screening platform to study inter population differences in drug toxicity and adverse drug reactions.

CELL REPORTS (2022)

Article Health Care Sciences & Services

Establishment and Characterization of MUi027-A: A Novel Patient-Derived Cell Line of Polycystic Kidney Disease with PKD1 Mutation

Aung Khine Linn et al.

Summary: In this study, researchers developed and characterized a novel human induced pluripotent stem cell line with a specific PKD mutation, demonstrating its potential as a disease model for studying the pathophysiology of genetic determinants in the development of autosomal dominant polycystic kidney disease (ADPKD).

JOURNAL OF PERSONALIZED MEDICINE (2022)

Article Cardiac & Cardiovascular Systems

Case report: Transplantation of human induced pluripotent stem cell-derived cardiomyocyte patches for ischemic cardiomyopathy

Shigeru Miyagawa et al.

Summary: Despite being a life-threatening disease, heart failure can potentially be treated using allogenic human induced pluripotent stem cell-derived cardiomyocyte (hiPSC-CM) patches. The successful implantation of these patches in a patient with severe ischemic cardiomyopathy showed potential efficacy, safety, and tolerability, improving clinical symptoms and recovering wall motion at the transplanted site.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2022)

Review Biotechnology & Applied Microbiology

Organs-on-chips: into the next decade

Lucie A. Low et al.

Summary: OoCs, also known as microphysiological systems or 'tissue chips', have the potential to be informative at multiple stages of drug discovery and development, providing insights into normal human organ function and disease pathophysiology, as well as predicting the safety and efficacy of investigational drugs in humans. The field of OoCs has seen significant advances in recent years, but there are still challenges and opportunities that need to be addressed to fully realize their potential for translational research.

NATURE REVIEWS DRUG DISCOVERY (2021)

Review Physiology

Human-induced pluripotent stem cells as models for rare cardiovascular diseases: from evidence-based medicine to precision medicine

Ziwei Pan et al.

Summary: Rare cardiovascular diseases (RCDs) present challenges for diagnosis due to the vast variety of underlying genetic mutations and relatively low patient populations, but precision medicine may provide patient-specific therapies. Induced pluripotent stem cell technology has made contributions to studying RCDs through patient-specific cardiomyocytes, offering personalized disease models.

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2021)

Review Urology & Nephrology

iPSC technology-based regenerative medicine for kidney diseases

Kenji Osafune

Summary: In recent years, significant progress has been made in kidney regeneration using human-induced pluripotent stem cells (hiPSCs), including successful differentiation into nephron progenitor cells and ureteric bud, generating kidney tissues for transplantation and treating acute kidney injury. Additionally, disease modeling and drug discovery research using hiPSCs are actively pursued for intractable kidney disorders.

CLINICAL AND EXPERIMENTAL NEPHROLOGY (2021)

Review Chemistry, Analytical

Potential of Drug Efficacy Evaluation in Lung and Kidney Cancer Models Using Organ-on-a-Chip Technology

Seong-Hye Hwang et al.

Summary: Organ-on-a-chip (OoC) is a promising technology that has the potential to revolutionize disease research, toxicology, and drug discovery. Further validation is needed to assess the relevance of OoC models in predicting clinical outcomes and understanding disease mechanisms. Exciting avenues for drug development and discovery could emerge from advancements in this field.

MICROMACHINES (2021)

Article Cell & Tissue Engineering

Generation of induced pluripotent stem cells from a Bardet-Biedl syndrome patient carrying a homologous BBS2 c.534+1G > T mutation

Chien-Yu Ting et al.

Summary: Bardet-Biedl syndrome is a hereditary disorder characterized by various symptoms. We generated and characterized an iPS cell line from a patient carrying a specific mutation associated with the syndrome, which retained the mutation and showed pluripotency and differentiation ability.

STEM CELL RESEARCH (2021)

Article Multidisciplinary Sciences

Efficient derivation of human trophoblast stem cells from primed pluripotent stem cells

Yanxing Wei et al.

Summary: This passage discusses the successful generation of trophoblast stem cells from primed human pluripotent stem cells, with BMP4 playing a significant role in the process. The derived TSCs are similar to blastocyst-derived hTSCs in various characteristics, and the chromatin accessibility dynamics and histone modifications involved in specifying hPSC-derived TSCs are defined. Additionally, knockout of H3K27 methyltransferases (EZH1/2) is shown to increase the efficiency of hTSC derivation from primed hPSCs.

SCIENCE ADVANCES (2021)

Review Biochemistry & Molecular Biology

Human iPSC modeling of heart disease for drug development

Anna P. Hnatiuk et al.

Summary: Human induced pluripotent stem cells (hiPSCs) show promise in pharmacogenomics and drug development, particularly in cardiology. However, the translation hurdles need to be overcome for widespread adoption in pharmaceutical development for heart disease treatments.

CELL CHEMICAL BIOLOGY (2021)

Editorial Material Medicine, Research & Experimental

Tissue Chips in Space-Challenges and Opportunities

Catherine K. Yeung et al.

CTS-CLINICAL AND TRANSLATIONAL SCIENCE (2020)

Article Medicine, General & Internal

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

Chaolin Huang et al.

LANCET (2020)

Review Cell & Tissue Engineering

Multi-lineage Human iPSC-Derived Platforms for Disease Modeling and Drug Discovery

Arun Sharma et al.

CELL STEM CELL (2020)

Article Biochemistry & Molecular Biology

Infection of bat and human intestinal organoids by SARS-CoV-2

Zhou Jie et al.

NATURE MEDICINE (2020)

Article Medicine, General & Internal

Multiorgan and Renal Tropism of SARS-CoV-2

Victor G. Puelles et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Review Biochemistry & Molecular Biology

An Overview of In Vivo and In Vitro Models for Autosomal Dominant Polycystic Kidney Disease: A Journey from 3D-Cysts to Mini-Pigs

Svenja Koslowski et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Urology & Nephrology

PKD1-Dependent Renal Cystogenesis in Human Induced Pluripotent Stem Cell-Derived Ureteric Bud/Collecting Duct Organoids

Shohei Kuraoka et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2020)

Article Biochemistry & Molecular Biology

A novel ADPKD model using kidney organoids derived from disease-specific human iPSCs

Tatsuya Shimizu et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

Review Biochemistry & Molecular Biology

Effects of COVID-19 on the Nervous System

Costantino Iadecola et al.

Review Cell & Tissue Engineering

Pluripotent Stem Cell-Based Cell Therapy- Promise and Challenges

Shinya Yamanaka

CELL STEM CELL (2020)

Article Biochemistry & Molecular Biology

SARS-CoV-2 targets neurons of 3D human brain organoids

Anand Ramani et al.

EMBO JOURNAL (2020)

Letter Medicine, General & Internal

SARS-CoV-2 renal tropism associates with acute kidney injury

Fabian Braun et al.

LANCET (2020)

Article Engineering, Biomedical

iPS cell-based therapy for Parkinson's disease: A Kyoto trial

Jun Takahashi

Regenerative Therapy (2020)

Article Cell Biology

Human iPSC-Derived Cardiomyocytes Are Susceptible to SARS-CoV-2 Infection

Arun Sharma et al.

CELL REPORTS MEDICINE (2020)

Article Cell & Tissue Engineering

Scaffolding kidney organoids on silk

Ashwani Kumar Gupta et al.

JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2019)

Article Biochemical Research Methods

Flow-enhanced vascularization and maturation of kidney organoids in vitro

Kimberly A. Homan et al.

NATURE METHODS (2019)

Review Cell Biology

Kidney organoids: accurate models or fortunate accidents

Melissa H. Little et al.

GENES & DEVELOPMENT (2019)

Review Physiology

INDUCED PLURIPOTENT STEM CELLS AND THEIR USE IN HUMAN MODELS OF DISEASE AND DEVELOPMENT

Peter Karagiannis et al.

PHYSIOLOGICAL REVIEWS (2019)

Article Medicine, Research & Experimental

iPSC-derived functional human neuromuscular junctions model the pathophysiology of neuromuscular diseases

Chuang-Yu Lin et al.

JCI INSIGHT (2019)

Review Immunology

Overview: an iPS cell stock at CiRA

Masafumi Umekage et al.

INFLAMMATION AND REGENERATION (2019)

Review Cell Biology

Human iPSC banking: barriers and opportunities

Ching-Ying Huang et al.

JOURNAL OF BIOMEDICAL SCIENCE (2019)

Article Biochemistry & Molecular Biology

Generation of branching ureteric bud tissues from human pluripotent stem cells

Shin-Ichi Mae et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

Review Cell & Tissue Engineering

Organs-on-a-Chip: A Fast Track for Engineered Human Tissues in Drug Development

Kacey Ronaldson-Bouchard et al.

CELL STEM CELL (2018)

Article Biotechnology & Applied Microbiology

Human embryonic stem cell-derived cardiomyocytes restore function in infarcted hearts of non-human primates

Yen-Wen Liu et al.

NATURE BIOTECHNOLOGY (2018)

Article Biochemical Research Methods

Generation of nephron progenitor cells and kidney organoids from human pluripotent stem cells

Ryuji Morizane et al.

NATURE PROTOCOLS (2017)

Article Cell & Tissue Engineering

Higher-Order Kidney Organogenesis from Pluripotent Stem Cells

Atsuhiro Taguchi et al.

CELL STEM CELL (2017)

Article Medicine, General & Internal

Autosomal dominant polycystic kidney disease: the changing face of clinical management

Albert C. M. Ong et al.

LANCET (2015)

Article Biotechnology & Applied Microbiology

Nephron organoids derived from human pluripotent stem cells model kidney development and injury

Ryuji Morizane et al.

NATURE BIOTECHNOLOGY (2015)

Article Multidisciplinary Sciences

Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids

Benjamin S. Freedman et al.

NATURE COMMUNICATIONS (2015)

Article Biotechnology & Applied Microbiology

A comparison of non-integrating reprogramming methods

Thorsten M. Schlaeger et al.

NATURE BIOTECHNOLOGY (2015)

Article Multidisciplinary Sciences

Human embryonic-stem-cell-derived cardiomyocytesregenerate non-humanprimate hearts

James J. H. Chong et al.

NATURE (2014)

Article Urology & Nephrology

Reduced Ciliary Polycystin-2 in Induced Pluripotent Stem Cells from Polycystic Kidney Disease Patients with PKD1 Mutations

Benjamin S. Freedman et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2013)

Article Multidisciplinary Sciences

Monitoring and robust induction of nephrogenic intermediate mesoderm from human pluripotent stem cells

Shin-Ichi Mae et al.

NATURE COMMUNICATIONS (2013)

Review Cardiac & Cardiovascular Systems

Induced Pluripotent Stem Cells as a Disease Modeling and Drug Screening Platform

Antje D. Ebert et al.

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY (2012)

Article Biochemistry & Molecular Biology

Development of Defective and Persistent Sendai Virus Vector A UNIQUE GENE DELIVERY/EXPRESSION SYSTEM IDEAL FOR CELL REPROGRAMMING

Ken Nishimura et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Multidisciplinary Sciences

Direct reprogramming of somatic cells is promoted by maternal transcription factor Glis1

Momoko Maekawa et al.

NATURE (2011)

Review Anatomy & Morphology

Induced pluripotent stem cells and personalized medicine: current progress and future perspectives

Yong Soon Chun et al.

ANATOMY & CELL BIOLOGY (2011)

Article Cell & Tissue Engineering

The Nuclear Receptor Nr5a2 Can Replace Oct4 in the Reprogramming of Murine Somatic Cells to Pluripotent Cells

Jian-Chien Dominic Heng et al.

CELL STEM CELL (2010)

Article Cell Biology

The International Stem Cell Banking Initiative (ISCBI): raising standards to bank on

Jeremy Micah Crook et al.

IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL (2010)

Review Cell Biology

The cell biology of polycystic kidney disease

Hannah C. Chapin et al.

JOURNAL OF CELL BIOLOGY (2010)

Article Multidisciplinary Sciences

Efficient induction of transgene-free human pluripotent stem cells using a vector based on Sendai virus, an RNA virus that does not integrate into the host genome

Noemi Fusaki et al.

PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES (2009)

Article Biochemistry & Molecular Biology

Induction of pluripotent stem cells from adult human fibroblasts by defined factors

Kazutoshi Takahashi et al.

Review Medicine, General & Internal

Autosomal dominant polycystic kidney disease

Vicente E. Torres et al.

LANCET (2007)