Hypoxia-Induced Downregulation of miR-29 in Renal Tumor Cells Affects Collagen IV Subunit Expression through Multiple Sites

Review Cell Biology

The hallmarks of cancer metabolism: Still emerging

Natalya N. Pavlova et al.

Summary: The metabolism of cancer cells is highly adaptable, allowing them to sustain growth and proliferation. This adaptation can also influence the behavior of non-transformed cells in the tumor vicinity.

CELL METABOLISM (2022)

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Article Biochemistry & Molecular Biology

miRNA Pattern in Hypoxic Microenvironment of Kidney Cancer-Role of PTEN

Aleksandra Majewska et al.

Summary: MicroRNAs are important regulators of gene expression and play a role in various pathological states, including cancer. This study focuses on the miRNA pattern in renal cancer and its association with hypoxia and PTEN dysregulation. The findings show that hypoxia induces changes in miRNA expression, and the loss of PTEN affects the response to hypoxia. It is important to consider the specificity of the tumor microenvironment and key suppressor mutations when identifying miRNA patterns in cancer.

BIOMOLECULES (2022)

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Review Genetics & Heredity

Crosstalk between Hypoxia and Extracellular Matrix in the Tumor Microenvironment in Breast Cancer

Yasmin Dekker et al.

Summary: This review studies the crosstalk between hypoxia and the extracellular matrix (ECM) in breast cancer. The findings suggest that hypoxia directly contributes to ECM remodeling, alters cell metabolism, and is regulated by the YAP/TAZ mechanotransduction pathway. The review highlights the importance of understanding these interactions for breast cancer progression.

GENES (2022)

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Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Review Biochemistry & Molecular Biology

The role of miR-29 family in disease

Masahiro Horita et al.

Summary: This review summarizes the differential expression patterns and functional roles of the miR-29 family in diseases such as osteoarthritis, osteoporosis, cardiorenal, and immune disease, highlighting their therapeutic potential. Further research is needed to identify the precise mechanisms of the miR-29 family in these diseases and their potential in therapeutics.

JOURNAL OF CELLULAR BIOCHEMISTRY (2021)

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Article Oncology