Analysis of a Sabin-Strain Inactivated Poliovirus Vaccine Response to a Circulating Type 2 Vaccine-Derived Poliovirus Event in Sichuan Province, China 2019-2021

Review Immunology

Review of use of inactivated poliovirus vaccine in campaigns to control type 2 circulating vaccine derived poliovirus (cVDPV) outbreaks q

Concepcion F. Estivariz et al.

Summary: Delivering IPV alongside OPV can improve immunity against cVDPV. A booster dose of IPV after at least two doses of OPV is more effective than an additional dose of trivalent OPV. However, IPV alone has minimal advantage over monovalent and bivalent OPV in terms of humoral immunity and cannot provide intestinal immunity. Adding IPV to polio campaigns increases cost and logistic complexity, requiring smaller targeted areas and phased implementation. Delivery challenges through house-to-house visits increase the risk of missing children who would benefit from IPV. SAGE recommends routine immunization with a second dose of IPV and the use of type 2 OPV in high-quality campaigns to reduce paralytic cases and prevent new cVDPV outbreaks.

VACCINE (2023)

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Article Biotechnology & Applied Microbiology

Safety and immunogenicity of 3 formulations of a Sabin inactivated paliovirus vaccine produced on the PER.C6® cell line: A phase 2, double-blind, randomized, controlled study in infants vaccinated at 6, 10 and 14 weeks of age

Anna Lisa Ong-Lim et al.

Summary: An inactivated poliovirus vaccine candidate using Sabin strains grown on the PER.C6 (R) cell line showed acceptable safety profile and immunogenicity in infants. However, lower seroprotection against type 1 warrants optimization of dose level and additional clinical evaluation.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2022)

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Editorial Material Medicine, General & Internal

Detection of poliovirus in London highlights the value of sewage surveillance

Matilda Hill et al.

LANCET (2022)

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Article Medicine, General & Internal

Sustained detection of type 2 poliovirus in London sewage between February and July, 2022, by enhanced environmental surveillance

Dimitra Klapsa et al.

Summary: Environmental surveillance in London identified genetically linked poliovirus isolates related to the Sabin vaccine strain, with an increasing proportion meeting the criteria for vaccine-derived poliovirus. Whole-genome sequencing confirmed transmission of a unique recombinant poliovirus lineage, now detected in Israel and the USA.

LANCET (2022)

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Article Medicine, General & Internal

Safety and immunogenicity of two novel type 2 oral poliovirus vaccine candidates compared with a monovalent type 2 oral poliovirus vaccine in healthy adults: two clinical trials

Ilse De Coster et al.

Summary: Two novel type 2 oral poliovirus vaccine candidates were developed to address ongoing polio outbreaks, and were found to be as safe, well tolerated, and immunogenic as the licensed Sabin monovalent OPV2 in previously vaccinated adults, supporting further evaluation in children and infants.

LANCET (2021)

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Article Immunology

Immunogenicity and safety of sabin-strain based inactivated poliovirus vaccine replacing salk-strain based inactivated poliovirus vaccine: An innovative application of different strain-IPVs replacement

Haiping Chen et al.

Summary: The study indicated that the Salk-Sabin-Sabin IPV immunization schedule is not inferior to the Salk-Salk-Salk IPV schedule in terms of both immunogenicity and safety, demonstrating that it is a safe and effective alternative for vaccine recipients.

VACCINE (2021)

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Article Public, Environmental & Occupational Health