Assessment of COVID-19 as the Underlying Cause of Death Among Children and Young People Aged 0 to 19 Years in the US

Article Environmental Sciences

Room-level ventilation in schools and universities

V. Faye McNeill et al.

Summary: Ventilation is crucial for maintaining healthy indoor air quality and reducing the spread of infectious diseases. However, many universities and schools lack room-level ventilation data for classrooms and other key spaces. This article provides an overview of approaches for measuring ventilation, along with their advantages and disadvantages. It also presents data from case studies across various institutions in the United States, highlighting their similarities and differences, and examples of using this data for decision making.

ATMOSPHERIC ENVIRONMENT-X (2022)

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Article Infectious Diseases

Hospital admission and emergency care attendance risk for SARS-CoV-2 delta (B.1.617.2) compared with alpha (B.1.1.7) variants of concern: a cohort study

Katherine A. Twohig et al.

Summary: A study in England found that patients with COVID-19 infected with the delta variant were more likely to be admitted to hospital or attend emergency care compared to those infected with the alpha variant. This suggests that outbreaks of the delta variant in unvaccinated populations may pose a greater burden on healthcare services.

LANCET INFECTIOUS DISEASES (2022)

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Article Medicine, General & Internal

Comparative analysis of the risks of hospitalisation and death associated with SARS-CoV-2 omicron (B.1.1.529) and delta (B.1.617.2) variants in England: a cohort study

Tommy Nyberg et al.

Summary: The Omicron variant shows lower severity compared to Delta, especially in terms of hospital admission and death, with significant variations by age. Unvaccinated cases experience a larger reduction in intrinsic severity, while vaccinated cases experience reduced vaccine effectiveness. Booster vaccination with mRNA vaccines provides over 70% protection against hospitalization and death in breakthrough Omicron infections.

LANCET (2022)

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Letter Medicine, General & Internal

SARS-CoV-2 co-infection with influenza viruses, respiratory syncytial virus, or adenoviruses

Maaike C. Swets et al.

LANCET (2022)

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Editorial Material Microbiology

Antigenic evolution will lead to new SARS-CoV-2 variants with unpredictable severity

Peter Markov et al.

Summary: The milder infections with Omicron variant and higher levels of population immunity have led to hopes for a weakening pandemic. However, the authors argue that the lower severity of Omicron is coincidental and ongoing rapid antigenic evolution may generate new variants that can evade immunity and be more severe.

NATURE REVIEWS MICROBIOLOGY (2022)

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Article Medicine, General & Internal

BNT162b2 Protection against the Omicron Variant in Children and Adolescents

A. M. Price et al.

Summary: In this study evaluating BNT162b2, vaccine effectiveness against hospitalization for Covid-19 in the delta-predominant period among adolescents 12 to 18 years of age was more than 90%; during the omicron period, vaccine effectiveness was 40% against hospitalization and 79% against critical illness. Vaccine effectiveness against hospitalization was 68% among children 5 to 11 years of age.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

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Letter Pediatrics

Incidence Rates and Clinical Outcomes of SARS-CoV-2 Infection With the Omicron and Delta Variants in Children Younger Than 5 Years in the US

Lindsey Wang et al.

Summary: This cohort study evaluates the incidence rates and clinical outcomes of SARS-CoV-2 infection caused by the Omicron and Delta variants in children younger than 5 years in the United States.

JAMA PEDIATRICS (2022)

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Article Public, Environmental & Occupational Health

Post–COVID-19 Symptoms and Conditions Among Children and Adolescents — United States, March 1, 2020–January 31, 2022

Lyudmyla Kompaniyets et al.

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT (2022)

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Article Immunology

Warp Speed for Coronavirus Disease 2019 (COVID-19) Vaccines: Why Are Children Stuck in Neutral?

Evan J. Anderson et al.

Summary: While clinical trials for COVID-19 vaccines in adults have progressed quickly, trials in children have not yet started. The direct impact of COVID-19 on children is significant, highlighting the importance of pediatric vaccination. Therefore, initiating phase 2 clinical trials for children should be a priority to address safety concerns and help in the recovery from COVID-19.

CLINICAL INFECTIOUS DISEASES (2021)

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Editorial Material Medicine, General & Internal