Journal
CURRENT OPINION IN GREEN AND SUSTAINABLE CHEMISTRY
Volume 40, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.cogsc.2023.100774
Keywords
Polar aprotic solvents Water Aqueous solvent Replacement of organic; synthesis
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Contrary to the risks associated with traditional polar aprotic solvents, water has been considered an ideal alternative in organic synthesis due to its abundant supply and environmental compatibility. However, challenges such as low solubility of organic compounds and instability of water-incompatible catalysts hinder its practical use as a reaction medium. This review summarizes strategies to address these issues, including the use of task-specific surfactant-based catalysts and water-containing cosolvents, which offer a promising future for replacing hazardous polar aprotic solvents with water. Additionally, innovative technologies like biomimetic catalysis and continuous-flow reactions may pave the way for large-scale adoption of water as a solvent.
In contrast to the risks of traditional polar aprotic solvents to health, safety, and environment, water with many advantages, such as abundance, environmental compatibility, has been regarded as ideal alternative to polar aprotic solvents in organic synthesis. However, inferior reaction rate caused by depressed solubility of organic compounds and instability of water-incompatible catalysts in water hinders practical and wide utilization of water as reaction medium. Strategies employed to solve the abovementioned issues in synthetic reactions have been summarized in this review, including the use of task-specific surfactant-based catalysts in pure water and the use of water-containing cosolvents. The two comple-mentary strategies are desired to give a brighter future for replacing hazardous polar aprotic solvents with water. In addition, with the aid of pluralistic and innovative technologies, for example, biomimetic catalysis and continuous-flow reac-tion, the replacement of polar aprotic solvents with water in a large scale could be around the corner.
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