Journal
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
Volume 15, Issue 4, Pages 931-947Publisher
ELSEVIER INC
DOI: 10.1016/j.jcmgh.2022.12.012
Keywords
Intestinal Stem Cells; Glycolysis; HK2; Metabolism
Categories
Ask authors/readers for more resources
Our findings indicate that glycolytic activity is essential for maintaining the self-renewal of intestinal stem cells (ISCs), and inhibiting glycolysis contributes to the differentiation of secretory lineages from ISCs. The dysregulation of glycolysis in ISCs disrupts the balance between self-renewal and differentiation.
Our findings demonstrate that glycolytic activity is neces-sary to maintain intestinal stem cell (ISC) self-renewal and that limiting glycolysis contributes to the generation of secretory lineages from ISCs. The inability to fine-tune glycolysis in ISCs subsequently disturbs the balance be-tween self-renewal and differentiation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available