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Interrelation between Programmed Cell Death and Immunogenic Cell Death: Take Antitumor Nanodrug as an Example

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Biodegradable Upconversion Nanoparticles Induce Pyroptosis for Cancer Immunotherapy

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Self-assembled nano-activator constructed ferroptosis-immunotherapy through hijacking endogenous iron to intracellular positive feedback loop

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Ultrasound-Augmented Mitochondrial Calcium Ion Overload by Calcium Nanomodulator to Induce Immunogenic Cell Death

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Continuous inertial cavitation evokes massive ROS for reinforcing sonodynamic therapy and immunogenic cell death against breast carcinoma

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Engineering a Hydrogen-Sulfide-Based Nanomodulator to Normalize Hyperactive Photothermal Immunogenicity for Combination Cancer Therapy

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Gene augmented nuclear-targeting sonodynamic therapy via Nrf2 pathway-based redox balance adjustment boosts peptide-based anti-PD-L1 therapy on colorectal cancer

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Smart biomimetic metal organic frameworks based on ROS-ferroptosis-glycolysis regulation for enhanced tumor chemo-immunotherapy

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MICROSCOPY AND MICROANALYSIS (2021)

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Review Chemistry, Multidisciplinary

Type I Photosensitizers Revitalizing Photodynamic Oncotherapy

Dapeng Chen et al.

Summary: Photodynamic therapy (PDT) has great potential for tumor treatment, with type I PDT showing superiority over type II PDT in treating hypoxic tumors. Recent research focuses on developing highly effective type I photosensitizers and addressing key challenges in clinical translations of these photosensitizers.

SMALL (2021)

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Article Toxicology

p53-mediated ferroptosis is required for 1-methyl-4-phenylpyridinium-in-duced senescence of PC12 cells

Shanshan Li et al.

Summary: The study found that ferroptosis associated with Parkinson's disease may accelerate the disease progression by promoting cellular senescence, and the use of an ferroptosis inhibitor can eliminate cellular senescence.

TOXICOLOGY IN VITRO (2021)

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Article Chemistry, Multidisciplinary

Multifunctional Nanodrug Mediates Synergistic Photodynamic Therapy and MDSCs-Targeting Immunotherapy of Colon Cancer

Dongbing Ding et al.

Summary: By combining immunogenic photodynamic therapy with MDSC-targeting immunotherapy, the synergistic treatment effectively inhibits tumor growth while promoting immune responses to prevent tumor recurrence and metastasis.

ADVANCED SCIENCE (2021)

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Review Oncology

Pyroptosis in Cancer: Friend or Foe?

Xiuxia Lu et al.

Summary: Pyroptosis, a new form of programmed cell death, has garnered attention in cancer research. Various stimuli can trigger pyroptosis, but its role in cancer remains unclear with conflicting findings. Despite the uncertainties, pyroptosis may hold potential as a promising anti-cancer therapy.

CANCERS (2021)

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Article Medicine, Research & Experimental

An eat me combinatory nano-formulation for systemic immunotherapy of solid tumors

Hend Mohamed Abdel-Bar et al.

Summary: The study developed a stable nucleic acid-lipid particles (SNALPs) formulation for the simultaneous delivery of ICD inducing drug and siRNA targeting CD47 for enhanced ICD. The results demonstrated the potential of this combination as a potent anti-tumor strategy for future clinical studies.

THERANOSTICS (2021)

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Review Biochemistry & Molecular Biology

The STING1 network regulates autophagy and cell death

Ruoxi Zhang et al.

Summary: STING1 plays a crucial role in infection, inflammation, and immunity by activating transcription factors, as well as regulating autophagy and various cell death modalities. Understanding the signaling pathways of STING1 may provide insights into new therapeutic targets.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Review Biochemistry & Molecular Biology

Pyroptosis: mechanisms and diseases

Pian Yu et al.

Summary: Pyroptosis has gained attention for its association with innate immunity and diseases. The discovery of the gasdermin family has expanded the research scope of pyroptosis, revealing its potential effects on tumor development. Pyroptosis serves as a double-edged sword in tumors, with the rational utilization of its dual effect providing insights for new drug development and understanding tumor formation and progression.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Review Oncology

Autophagy in tumour immunity and therapy

Houjun Xia et al.

Summary: Autophagy plays a crucial role in cancer by influencing tumor progression, immune responses, and therapy outcomes. Modulating the autophagy pathway can enhance antitumor immune responses and improve treatment efficacy.

NATURE REVIEWS CANCER (2021)

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Review Chemistry, Multidisciplinary

Photodynamic therapy: photosensitizers and nanostructures

Alberto Escudero et al.

Summary: This article discusses the application of photodynamic therapy in treating skin, eye diseases, and cancer, focusing on different photosensitizers, their chemical properties, their applications in nanostructures, and targeting strategies.

MATERIALS CHEMISTRY FRONTIERS (2021)

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Editorial Material Cell Biology

Iron expulsion by exosomes drives ferroptosis resistance

Paulina Strzyz

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

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Review Chemistry, Multidisciplinary

Manganese Oxide Nanomaterials: Synthesis, Properties, and Theranostic Applications

Binbin Ding et al.

ADVANCED MATERIALS (2020)

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Article Chemistry, Multidisciplinary

Necroptosis-Inducible Polymeric Nanobubbles for Enhanced Cancer Sonoimmunotherapy

Wooram Um et al.

ADVANCED MATERIALS (2020)

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Article Engineering, Biomedical

Integration of immunogenic activation and immunosuppressive reversion using mitochondrial-respiration-inhibited platelet-mimicking nanoparticles

Xiaoli Mai et al.

BIOMATERIALS (2020)

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Review Pharmacology & Pharmacy

Curcumin Sensitizes Cancers Towards TRAIL-induced Apoptosis via Extrinsic and Intrinsic Apoptotic Pathways

Siew Ching Ngai

CURRENT DRUG TARGETS (2020)

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Article Environmental Sciences

Copper sulfate-induced endoplasmic reticulum stress promotes hepatic apoptosis by activating CHOP, JNK and caspase-12 signaling pathways

Hongbin Wu et al.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2020)

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Article Engineering, Biomedical

Designing immunogenic nanotherapeutics for photothermal-triggered immunotherapy involving reprogramming immunosuppression and activating systemic antitumor responses

Jing Wang et al.

BIOMATERIALS (2020)

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Review Medicine, Research & Experimental

Cancer immunotherapy: Pros, cons and beyond

Shuzhen Tan et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

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Mitochondrial DNA in inflammation and immunity

Joel S. Riley et al.

EMBO REPORTS (2020)

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Article Chemistry, Multidisciplinary

Platelet Membrane-Camouflaged Magnetic Nanoparticles for Ferroptosis-Enhanced Cancer Immunotherapy

Qin Jiang et al.

SMALL (2020)

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Review Oncology

Consensus guidelines for the definition, detection and interpretation of immunogenic cell death

Lorenzo Galluzzi et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2020)

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Article Chemistry, Multidisciplinary

On-Demand Autophagy Cascade Amplification Nanoparticles Precisely Enhanced Oxaliplatin-Induced Cancer Immunotherapy

Xuhui Wang et al.

ADVANCED MATERIALS (2020)

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Article Chemistry, Multidisciplinary

MnOxNanospikes as Nanoadjuvants and Immunogenic Cell Death Drugs with Enhanced Antitumor Immunity and Antimetastatic Effect

Binbin Ding et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

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Article Immunology

Blocking drug-induced autophagy with chloroquine in HCT-116 colon cancer cells enhances DC maturation and T cell responses induced by tumor cell lysate

Jofer Andree Zamame Ramirez et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2020)

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Review Oncology

Ferroptosis, necroptosis, and pyroptosis in anticancer immunity

Rong Tang et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2020)

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Article Engineering, Biomedical

Programming cell pyroptosis with biomimetic nanoparticles for solid tumor immunotherapy

Pengfei Zhao et al.

BIOMATERIALS (2020)

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Review Oncology

Beyond Traditional Morphological Characterization of Lung Neuroendocrine Neoplasms: In Silico Study of Next-Generation Sequencing Mutations Analysis across the Four World Health Organization Defined Groups

Giovanni Centonze et al.

CANCERS (2020)

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Article Chemistry, Multidisciplinary

Na2S2O8 Nanoparticles Trigger Antitumor Immunotherapy through Reactive Oxygen Species Storm and Surge of Tumor Osmolarity

Yang Liu et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

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Review Oncology

Targeting immunogenic cell death in cancer

Asma Ahmed et al.

MOLECULAR ONCOLOGY (2020)

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Article Chemistry, Multidisciplinary

Carrier-free nanoassembly of doxorubicin prodrug and siRNA for combinationally inducing immunogenic cell death and reversing immunosuppression

Senbiao Chen et al.

NANO TODAY (2020)

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Article Pharmacology & Pharmacy

Doxorubicin-Loaded PLGA Nanoparticles for Cancer Therapy: Molecular Weight Effect of PLGA in Doxorubicin Release for Controlling Immunogenic Cell Death

Yongwhan Choi et al.

PHARMACEUTICS (2020)

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Article Materials Science, Multidisciplinary

Induction of Immunogenic Cell Death in Breast Cancer by Conductive Polymer Nanoparticle-Mediated Photothermal Therapy

Madeline Elaine Huff et al.

ACS APPLIED POLYMER MATERIALS (2020)

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Review Cell Biology

The caspase-3/GSDME signal pathway as a switch between apoptosis and pyroptosis in cancer

Mingxia Jiang et al.

CELL DEATH DISCOVERY (2020)

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Review Chemistry, Multidisciplinary

The role of reactive oxygen species in tumor treatment

Pengpeng Jia et al.

RSC ADVANCES (2020)

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Article Biochemistry & Molecular Biology

The release and activity of HMGB1 in ferroptosis

Qirong Wen et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)

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Article Oncology

Glucose starvation induces resistance to metformin through the elevation of mitochondrial multidrug resistance protein 1

Sung-Hyun Hwang et al.

CANCER SCIENCE (2019)

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Article Biochemistry & Molecular Biology

Apoptotic Caspases Suppress Type I Interferon Production via the Cleavage of cGAS, MAVS, and IRF3

Xiaohan Ning et al.

MOLECULAR CELL (2019)

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Article Multidisciplinary Sciences

Chaperone-mediated autophagy is involved in the execution of ferroptosis

Zheming Wu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

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Article Cell Biology

Cleavage of GSDME by caspase-3 determines lobaplatin-induced pyroptosis in colon cancer cells

Junhui Yu et al.

CELL DEATH & DISEASE (2019)

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Article Chemistry, Multidisciplinary

Engineering Magnetosomes for Ferroptosis/Immunomodulation Synergism in Cancer

Fan Zhang et al.

ACS NANO (2019)

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Editorial Material Biochemistry & Molecular Biology

Autophagy

Thomas Wollert

CURRENT BIOLOGY (2019)

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Review Chemistry, Multidisciplinary

Gas-Mediated Cancer Bioimaging and Therapy

Lichan Chen et al.

ACS NANO (2019)

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Article Chemistry, Multidisciplinary

Near-Infrared II Phototherapy Induces Deep Tissue Immunogenic Cell Death and Potentiates Cancer Immunotherapy

Yinchu Ma et al.

ACS NANO (2019)

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Article Chemistry, Multidisciplinary

Co-delivery of Bee Venom Melittin and a Photosensitizer with an Organic-Inorganic Hybrid Nanocarrier for Photodynamic Therapy and Immunotherapy

Haojie Liu et al.

ACS NANO (2019)

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Article Biochemistry & Molecular Biology

Caspase-8 Regulates Endoplasmic Reticulum Stress-Induced Necroptosis Independent of the Apoptosis Pathway in Auditory Cells

Akihiro Kishino et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Review Oncology

Tumor-intrinsic signaling pathways: key roles in the regulation of the immunosuppressive tumor microenvironment

Li Yang et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2019)

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Article Multidisciplinary Sciences

Supramolecular trap for catching polyamines in cells as an anti-tumor strategy

Junyi Chen et al.

NATURE COMMUNICATIONS (2019)

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Doxorubicin-polyglycerol-nanodiamond composites stimulate glioblastoma cell immunogenicity through activation of autophagy

Tong-Fei Li et al.

ACTA BIOMATERIALIA (2019)

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Article Biochemistry & Molecular Biology

Lipid storage and lipophagy regulates ferroptosis

Yuansong Bai et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)

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Review Biochemistry & Molecular Biology

Programmed Necrosis and Disease: We interrupt your regular programming to bring you necroinflammation

Eui Ho Kim et al.

CELL DEATH AND DIFFERENTIATION (2019)

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Article Chemistry, Multidisciplinary

Bioinspired Hybrid Protein Oxygen Nanocarrier Amplified Photodynamic Therapy for Eliciting Anti-tumor Immunity and Abscopal Effect

Zhikuan Chen et al.

ACS NANO (2018)

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Review Medical Laboratory Technology

Pyroptosis and its relationship to atherosclerosis

Yuan-Jun Xu et al.

CLINICA CHIMICA ACTA (2018)

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Meeting Abstract Biochemistry & Molecular Biology

Ferroptosis: Death by lipid peroxidation

Brent R. Stockwell

FREE RADICAL BIOLOGY AND MEDICINE (2018)

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Review Biochemistry & Molecular Biology

Nitric Oxide Signaling in T Cell-Mediated Immunity

Almudena Garcia-Ortiz et al.

TRENDS IN MOLECULAR MEDICINE (2018)

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Article Multidisciplinary Sciences

Autophagy promotes the survival of dormant breast cancer cells and metastatic tumour recurrence

Laura Vera-Ramirez et al.

NATURE COMMUNICATIONS (2018)

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Article Oncology

eIF2α phosphorylation: A hallmark of immunogenic cell death

Lucillia Bezu et al.

ONCOIMMUNOLOGY (2018)

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Article Oncology

Induction of enhanced immunogenic cell death through ultrasound-controlled release of doxorubicin by liposome-microbubble complexes

Feng-Ying Huang et al.

ONCOIMMUNOLOGY (2018)

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Review Immunology

Immunotherapy as an Option for Cancer Treatment

Tillmann Rusch et al.

ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS (2018)

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Article Biochemistry & Molecular Biology

Reduced risk of apoptosis: mechanisms of stress responses

Irina Milisav et al.

APOPTOSIS (2017)

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Review Cell Biology

Dual role for the unfolded protein response in the ovary: adaption and apoptosis

Ning Huang et al.

PROTEIN & CELL (2017)

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High drug-loading nanomedicines: progress, current status, and prospects

Shihong Shen et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2017)

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Article Multidisciplinary Sciences

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

Yupeng Wang et al.

NATURE (2017)

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Lysosomes as Oxidative Targets for Cancer Therapy

Rebecca F. Dielschneider et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2017)

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Sonodynamic therapy, a treatment developing from photodynamic therapy

Liu Rengeng et al.

PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY (2017)

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Programmed Cell Death and Inflammation: Winter Is Coming

Joseph P. Kolb et al.

TRENDS IN IMMUNOLOGY (2017)

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Article Nanoscience & Nanotechnology

A Novel Type of Aqueous Dispersible Ultrathin-Layered Double Hydroxide Nanosheets for in Vivo Bioimaging and Drug Delivery

Li Yan et al.

ACS APPLIED MATERIALS & INTERFACES (2017)

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Review Immunology

Immunogenic cell death in cancer and infectious disease

Lorenzo Galluzzi et al.

NATURE REVIEWS IMMUNOLOGY (2017)

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Article Cell Biology

Autophagy promotes ferroptosis by degradation of ferritin

Wen Hou et al.

AUTOPHAGY (2016)

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Article Cell Biology

Pyroptosis is driven by non-selective gasdermin-D pore and its morphology is different from MLKL channel-mediated necroptosis

Xin Chen et al.

CELL RESEARCH (2016)

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Review Biochemistry & Molecular Biology

Endoplasmic Reticulum Stress and Associated ROS

Hafiz Maher Ali Zeeshan et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)

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Article Biochemical Research Methods

Comprehensive analysis of mitochondrial permeability transition pore activity in living cells using fluorescence-imaging-based techniques

Massimo Bonora et al.

NATURE PROTOCOLS (2016)

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The future of cancer treatment: immunomodulation, CARs and combination immunotherapy

Danny N. Khalil et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2016)

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Article Biochemistry & Molecular Biology

Hypoxia-induced oxidative stress promotes MUC4 degradation via autophagy to enhance pancreatic cancer cells survival

S. Joshi et al.

ONCOGENE (2016)

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Article Cell Biology

Vaccination with Necroptotic Cancer Cells Induces Efficient Anti-tumor Immunity

Tania Love Aaes et al.

CELL REPORTS (2016)

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Article Biochemistry & Molecular Biology

Mitochondrial dysfunction activates the AMPK signaling and autophagy to promote cell survival

Baozhong Zhao et al.

GENES & DISEASES (2016)

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Anthracyclines potentiate anti-tumor immunity: A new opportunity for chemoimmunotherapy

Zhigang Zhang et al.

CANCER LETTERS (2015)

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Chemotherapy Induces Programmed Cell Death-Ligand 1 Overexpression via the Nuclear Factor-κB to Foster an Immunosuppressive Tumor Microenvironment in Ovarian Cancer

Jin Peng et al.

CANCER RESEARCH (2015)

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Article Oncology

Treating cancer with sonodynamic therapy: A review

David Costley et al.

INTERNATIONAL JOURNAL OF HYPERTHERMIA (2015)

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Apoptotic Caspases Prevent the Induction of Type I Interferons by Mitochondrial DNA

Anthony Rongvaux et al.

CELL (2014)

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Article Biochemistry & Molecular Biology

Regulation of Ferroptotic Cancer Cell Death by GPX4

Wan Seok Yang et al.

CELL (2014)

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Autophagic Cell Death and Cancer

Shigeomi Shimizu et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2014)

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Applications of Nanomedicine in Breast Cancer Detection, Imaging, and Therapy

Yamaan Saadeh et al.

JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY (2014)

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Article Multidisciplinary Sciences

Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis

Min Lu et al.

SCIENCE (2014)

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Mitochondria-mediated apoptosis in mammals

Shunbin Xiong et al.

PROTEIN & CELL (2014)

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Cell-Mediated Autophagy Promotes Cancer Cell Survival

William J. Buchser et al.

CANCER RESEARCH (2012)

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Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

Scott J. Dixon et al.

CELL (2012)

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Immunogenic cell death and DAMPs in cancer therapy

Dmitri V. Krysko et al.

NATURE REVIEWS CANCER (2012)

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Editorial Material Multidisciplinary Sciences

PROGRAMMED CELL DEATH Apoptosis meets necrosis

Marcus E. Peter

NATURE (2011)

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Methods in Mammalian Autophagy Research

Noboru Mizushima et al.

CELL (2010)

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Mechanisms of Tumor Cell Necrosis

Sergey Y. Proskuryakov et al.

CURRENT PHARMACEUTICAL DESIGN (2010)

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Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation

YoungSik Cho et al.

CELL (2009)

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Ultrasound, cavitation bubbles and their interaction with cells

Junru Wu et al.

ADVANCED DRUG DELIVERY REVIEWS (2008)

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Bid: a Bax-like BH3 protein

L. P. Billen et al.

ONCOGENE (2008)

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Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy

Lionel Apetoh et al.

NATURE MEDICINE (2007)

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Article Biochemistry & Molecular Biology

Calreticulin exposure dictates the immunogenicity of cancer cell death

Michel Obeid et al.

NATURE MEDICINE (2007)

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Article Biochemistry & Molecular Biology

Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury

A Degterev et al.

NATURE CHEMICAL BIOLOGY (2005)

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Article Multidisciplinary Sciences

Structure of the apoptotic protease-activating factor 1 bound to ADP

SJ Riedl et al.

NATURE (2005)

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Article Multidisciplinary Sciences

Quality control in the endoplasmic reticulum protein factory

R Sitia et al.

NATURE (2003)

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Review Oncology

Necrosis: a specific form of programmed cell death?

SY Proskuryakov et al.

EXPERIMENTAL CELL RESEARCH (2003)

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Article Anatomy & Morphology

Morphological and biochemical aspects of apoptosis, oncosis and necrosis

S Van Cruchten et al.

ANATOMIA HISTOLOGIA EMBRYOLOGIA (2002)

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Apoptosis: the quiet death silences the immune system

EW Sun et al.

PHARMACOLOGY & THERAPEUTICS (2001)

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Article Biochemistry & Molecular Biology

Analysis of FasL and TRAIL induced apoptosis pathways in glioma cells

MJ Knight et al.

ONCOGENE (2001)

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Letter Biochemistry & Molecular Biology

Pro-inflammatory programmed cell death

BT Cookson et al.

TRENDS IN MICROBIOLOGY (2001)

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Article Cell Biology

Changes in endoplasmic reticulum luminal environment affect cell sensitivity to apoptosis

K Nakamura et al.

JOURNAL OF CELL BIOLOGY (2000)

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Review Cell Biology

The morphology of apoptosis

G Häcker

CELL AND TISSUE RESEARCH (2000)

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