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Are natural killer cells superior CAR drivers?
Hans Klingemann
ONCOIMMUNOLOGY (2014)
Utilizing Cytokines to Function-Enable Human NK Cells for the Immunotherapy of Cancer
Rizwan Romee et al.
SCIENTIFICA (2014)
Primitive Neuroectodermal Tumor in an Ovarian Cystic Teratoma: Natural Killer and Neuroblastoma Cell Analysis
Giovanna Tabellini et al.
CASE REPORTS IN ONCOLOGY (2014)
Application of Aptamers for Targeted Therapeutics
Partha Ray et al.
ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS (2013)
Receptor Affinity and Extracellular Domain Modifications Affect Tumor Recognition by ROR1-Specific Chimeric Antigen Receptor T Cells
Michael Hudecek et al.
CLINICAL CANCER RESEARCH (2013)
Targeting Natural Killer Cells to Acute Myeloid Leukemia In Vitro with a CD16 x 33 Bispecific Killer Cell Engager and ADAM17 Inhibition
Andres Wiernik et al.
CLINICAL CANCER RESEARCH (2013)
Treatment of patients with advanced cancer with the natural killer cell line NK-92
Torsten Tonn et al.
CYTOTHERAPY (2013)
Modification of Hematopoietic Stem/Progenitor Cells with CD19-Specific Chimeric Antigen Receptors as a Novel Approach for Cancer Immunotherapy
Satiro Nakamura De Oliveira et al.
HUMAN GENE THERAPY (2013)
Natural killer cell biology: An update and future directions
Kerry S. Campbell et al.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2013)
IL-2-dependent tuning of NK cell sensitivity for target cells is controlled by regulatory T cells
Georg Gasteiger et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2013)
A critical review of the role of Fc gamma receptor polymorphisms in the response to monoclonal antibodies in cancer
James D. Mellor et al.
JOURNAL OF HEMATOLOGY & ONCOLOGY (2013)
Hypoxia Induced Impairment of NK Cell Cytotoxicity against Multiple Myeloma Can Be Overcome by IL-2 Activation of the NK Cells
Subhashis Sarkar et al.
PLOS ONE (2013)
Antigen Presenting Cell-Mediated Expansion of Human Umbilical Cord Blood Yields Log-Scale Expansion of Natural Killer Cells with Anti-Myeloma Activity
Nina Shah et al.
PLOS ONE (2013)
Clinical-Scale Derivation of Natural Killer Cells From Human Pluripotent Stem Cells for Cancer Therapy
David A. Knorr et al.
STEM CELLS TRANSLATIONAL MEDICINE (2013)
Characterization and ex vivo expansion of human placenta-derived natural killer cells for cancer immunotherapy
Lin Kang et al.
FRONTIERS IN IMMUNOLOGY (2013)
Innate lymphoid cells - a proposal for uniform nomenclature
Hergen Spits et al.
NATURE REVIEWS IMMUNOLOGY (2013)
Development of an Fc-Enhanced Anti-B7-H3 Monoclonal Antibody with Potent Antitumor Activity
Deryk Loo et al.
CLINICAL CANCER RESEARCH (2012)
Large-scale ex vivo expansion and characterization of natural killer cells for clinical applications
Natalia Lapteva et al.
CYTOTHERAPY (2012)
Decreased NKp46 and NKG2D and elevated PD-1 are associated with altered NK-cell function in pediatric transplant patients with PTLD
Silke Wiesmayr et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2012)
The unique profile of cord blood natural killer cells balances incomplete maturation and effective killing function upon activation
Martha Luevano et al.
HUMAN IMMUNOLOGY (2012)
Immune Surveillance Properties of Human NK Cell-Derived Exosomes
Luana Lugini et al.
JOURNAL OF IMMUNOLOGY (2012)
Human Cytomegalovirus (CMV)-Induced Memory-like NKG2C+ NK Cells Are Transplantable and Expand In Vivo in Response to Recipient CMV Antigen
Bree Foley et al.
JOURNAL OF IMMUNOLOGY (2012)
Characterisation of Bovine Leukocyte Ig-like Receptors
Louise Hogan et al.
PLOS ONE (2012)
Ex Vivo Generated Natural Killer Cells Acquire Typical Natural Killer Receptors and Display a Cytotoxic Gene Expression Profile Similar to Peripheral Blood Natural Killer Cells
Dorit Lehmann et al.
STEM CELLS AND DEVELOPMENT (2012)
Natural killer cell lines in tumor immunotherapy
Min Cheng et al.
Frontiers of Medicine (2012)
Heterodimeric bispecific antibody-derivatives against CD19 and CD16 induce effective antibody-dependent cellular cytotoxicity against B-lymphoid tumor cells
Christian Kellner et al.
CANCER LETTERS (2011)
IL-12 Release by Engineered T Cells Expressing Chimeric Antigen Receptors Can Effectively Muster an Antigen-Independent Macrophage Response on Tumor Cells That Have Shut Down Tumor Antigen Expression
Markus Chmielewski et al.
CANCER RESEARCH (2011)
Human Pluripotent Stem Cells Produce Natural Killer Cells That Mediate Anti-HIV-1 Activity by Utilizing Diverse Cellular Mechanisms
Zhenya Ni et al.
JOURNAL OF VIROLOGY (2011)
Clinical-Grade Generation of Active NK Cells from Cord Blood Hematopoietic Progenitor Cells for Immunotherapy Using a Closed-System Culture Process
Jan Spanholtz et al.
PLOS ONE (2011)
Natural Killer Cell Killing of Acute Myelogenous Leukemia and Acute Lymphoblastic Leukemia Blasts by Killer Cell Immunoglobulin-Like Receptor-Negative Natural Killer Cells after NKG2A and LIR-1 Blockade
Robert Godal et al.
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION (2010)
Good manufacturing practice-compliant cell sorting and large-scale expansion of single KIR-positive alloreactive human natural killer cells for multiple infusions to leukemia patients
Uwe Siegler et al.
CYTOTHERAPY (2010)
First-line chemoimmunotherapy in metastatic breast carcinoma: combination of paclitaxel and IMP321 (LAG-3Ig) enhances immune responses and antitumor activity
Chrystelle Brignone et al.
JOURNAL OF TRANSLATIONAL MEDICINE (2010)
Critical role for the chemokine receptor CXCR6 in NK cell-mediated antigen-specific memory of haptens and viruses
Silke Paust et al.
NATURE IMMUNOLOGY (2010)
Specific gene transfer to neurons, endothelial cells and hematopoietic progenitors with lentiviral vectors
Brigitte Anliker et al.
NATURE METHODS (2010)
SEPSIS Calming the cytokine storm
Charlotte Harrison
NATURE REVIEWS DRUG DISCOVERY (2010)
Extracellular adenosine triphosphate and adenosine in cancer
J. Stagg et al.
ONCOGENE (2010)
Replicative potential of human natural killer cells
Hiroyuki Fujisaki et al.
BRITISH JOURNAL OF HAEMATOLOGY (2009)
Therapeutic antibodies: successes, limitations and hopes for the future
Patrick Chames et al.
BRITISH JOURNAL OF PHARMACOLOGY (2009)
Natural killer cell cytotoxicity: how do they pull the trigger?
Nicola J. Topham et al.
IMMUNOLOGY (2009)
IL-12-Dependent Inducible Expression of the CD94/NKG2A Inhibitory Receptor Regulates CD94/NKG2C+ NK Cell Function
Andrea Saez-Borderias et al.
JOURNAL OF IMMUNOLOGY (2009)
Matrix Metalloprotease Inhibitors Restore Impaired NK Cell-Mediated Antibody-Dependent Cellular Cytotoxicity in Human Immunodeficiency Virus Type 1 Infection
Qingquan Liu et al.
JOURNAL OF VIROLOGY (2009)
Early lymphocyte recovery predicts superior survival after autologous stem cell transplantation in non-Hodgkin lymphoma: A prospective study
Luis F. Porrata et al.
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION (2008)
Regulation of NK cell responsiveness to achieve self-tolerance and maximal responses to diseased target cells
Nathalie T. Joncker et al.
IMMUNOLOGICAL REVIEWS (2008)
Antigen sensitivity of CD22-specific chimeric TCR is modulated by target epitope distance from the cell membrane
Scott T. James et al.
JOURNAL OF IMMUNOLOGY (2008)
Cutting Edge: Programmed Death-1/Programmed Death Ligand 1 Interaction Regulates the Induction and Maintenance of Invariant NKT Cell Anergy
Woo-Sung Chang et al.
JOURNAL OF IMMUNOLOGY (2008)
Cutting edge:: Priming of NK cells by IL-18
Julie Chaix et al.
JOURNAL OF IMMUNOLOGY (2008)
Natural killer cell recognition of missing self
Klas Karre
NATURE IMMUNOLOGY (2008)
Generation of a Novel Regulatory NK Cell Subset from Peripheral Blood CD34+ Progenitors Promoted by Membrane-Bound IL-15
Massimo Giuliani et al.
PLOS ONE (2008)
The contrasting role of B7-H3
Kimberly A. Hofmeyer et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Association of CD47 with natural killer cell-mediated cytotoxicity of head-and-neck squamous cell carcinoma lines
Min Jung Kim et al.
TUMOR BIOLOGY (2008)
Induction of pluripotent stem cells from adult human fibroblasts by defined factors
Kazutoshi Takahashi et al.
CELL (2007)
Identification, activation, and selective in vivo ablation of mouse NK cells via NKp46
Thierry Walzer et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
CD56dimCD16+ NK cells downregulate CD16 following target cell induced activation of matrix metalloproteinases
B. Grzywacz et al.
LEUKEMIA (2007)
In vivo kinetics of human natural killer cells: the effects of ageing and acute and chronic viral infection
Yan Zhang et al.
IMMUNOLOGY (2007)
Natural killer cells: from CD3(-)NKp46(+) to post-genomics meta-analyses
Thierry Walzer et al.
CURRENT OPINION IN IMMUNOLOGY (2007)
CD28-stimulated ERK2 phosphorylation is required for polarization of the microtubule organizing center and granules in YTS NK cells
Xi Chen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
T cell- and B cell-independent adaptive immunity mediated by natural killer cells
JG O'Leary et al.
NATURE IMMUNOLOGY (2006)
Human natural killer cell development and biology
Sherif S. Farag et al.
BLOOD REVIEWS (2006)
High concentrations of therapeutic IgG1 antibodies are needed to compensate for inhibition of antibody-dependent cellular cytotoxicity by excess endogenous immunoglobulin G
S Preithner et al.
MOLECULAR IMMUNOLOGY (2006)
Natural killer cells produce T cell-recruiting chemokines in response to antibody-coated tumor cells
JM Roda et al.
CANCER RESEARCH (2006)
Synergy among receptors on resting NK cells for the activation of natural cytotoxicity and cytokine secretion
YT Bryceson et al.
BLOOD (2006)
Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin
AM Intlekofer et al.
NATURE IMMUNOLOGY (2005)
CD4+ CD25+ regulatory T cells inhibit natural killer cell functions in a transforming growth factor-β-dependent manner
F Ghiringhelli et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2005)
Human embryonic stem cell-derived NK cells acquire functional receptors and cytolytic activity
PS Woll et al.
JOURNAL OF IMMUNOLOGY (2005)
Forced aggregation of defined numbers of human embryonic stem cells into embryoid bodies fosters robust, reproducible hematopoietic differentiation
ES Ng et al.
BLOOD (2005)
Expression of lymphocyte activation gene 3 (LAG-3) on B cells is induced by T cells
M Kisielow et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2005)
Genetic modification of primary natural killer cells overcomes inhibitory signals and induces specific killing of leukemic cells
C Imai et al.
BLOOD (2005)
The role of extracellular spacer regions in the optimal design of chimeric immune receptors - Evaluation of four different scFvs and antigens
RD Guest et al.
JOURNAL OF IMMUNOTHERAPY (2005)
Characterization of cord blood natural killer cells:: Implications for transplantation and neonatal infections
JH Dalle et al.
PEDIATRIC RESEARCH (2005)
Successful adoptive transfer and in vivo expansion of human haploidentical NK cells in patients with cancer
JS Miller et al.
BLOOD (2005)
Engineered antibody fragments and the rise of single domains
P Holliger et al.
NATURE BIOTECHNOLOGY (2005)
CD28-mediated co-stimulation: A quantitative support for TCR signalling
O Acuto et al.
NATURE REVIEWS IMMUNOLOGY (2003)
IL-2-based immunotherapy after autologous transplantation for lymphoma and breast cancer induces immune activation and cytokine release: a phase I/II trial
LJ Burns et al.
BONE MARROW TRANSPLANTATION (2003)
Analysis of natural killer (NK) cell activity and adhesion molecules on NK cells from umbilical cord blood
H Tanaka et al.
EUROPEAN JOURNAL OF HAEMATOLOGY (2003)
Human NK cell development in NOD/SCID mice receiving grafts of cord blood CD34+ cells
CP Kalberer et al.
BLOOD (2003)
A novel myeloid-like NK cell progenitor in human umbilical cord blood
SA Perez et al.
BLOOD (2003)
New aspects of natural-killer-cell surveillance and therapy of cancer
MJ Smyth et al.
NATURE REVIEWS CANCER (2002)
Multicolor-FISH analysis of a natural killer cell line (NK-92)
RAF MacLeod et al.
LEUKEMIA RESEARCH (2002)
KIR2DL4 (CD158d), an NK cell-activating receptor with inhibitory potential
M Faure et al.
JOURNAL OF IMMUNOLOGY (2002)
Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants
L Ruggeri et al.
SCIENCE (2002)
Structure and function of major histocompatibility complex (MHC) class I specific receptors expressed on human natural killer (NK) cells
F Borrego et al.
MOLECULAR IMMUNOLOGY (2002)
Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease
L Monney et al.
NATURE (2002)
Human T-lymphocyte cytotoxicity and proliferation directed by a single chimeric TCR zeta/CD28 receptor
J Maher et al.
NATURE BIOTECHNOLOGY (2002)
Tumor-specific T cell activation by recombinant immunoreceptors:: CD3ζ signaling and CD28 costimulation are simultaneously required for efficient IL-2 secretion and can ge integrated into one combined CD28/CD3ζ signaling receptor molecule
A Hombach et al.
JOURNAL OF IMMUNOLOGY (2001)
Factors regulating the cytotoxic activity of the human natural killer cell line, NK-92
G Maki et al.
JOURNAL OF HEMATOTHERAPY & STEM CELL RESEARCH (2001)
Enhancement of human cord blood CD34+ cell-derived NK cell cytotoxicity by dendritic cells
Y Yu et al.
JOURNAL OF IMMUNOLOGY (2001)
Cloning of a type I cytokine receptor most related to the IL-2 receptor β chain
K Ozaki et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
T cell activation by recombinant FcεRI γ-chain immune receptors:: an extracellular spacer domain impairs antigen-dependent T cell activation but not antigen recognition
A Hombach et al.
GENE THERAPY (2000)
Presence of primitive lymphoid progenitors with NK or B potential in ex vivo expanded bone marrow cell cultures
MC Giarratana et al.
EXPERIMENTAL HEMATOLOGY (2000)