Multicentric Carpo-Tarsal Osteolysis

MCTO is a rare autosomal-dominant inherited disorder that causes bone destruction and deformity of the appendicular bones in children, with the carpal and tarsal bones severely affected. Imaging can narrow the differential diagnosis between MTCO and other diseases that cause osteolysis of the joints in children. The MCTO diagnosis is confirmed by a mutation of the MAFB gene. Teaching Point: Multicentric carpo-tarsal osteolysis (MTCO) in childhood must be considered in the differential diagnosis of severe osteolysis on radiographs

Automated summary

MCTO is a rare autosomal-dominant inherited disorder that causes bone destruction and appendicular bone deformity in children, especially affecting the carpal and tarsal bones. Imaging is helpful in distinguishing MCTO from other diseases that cause joint osteolysis in children. The diagnosis of MCTO is confirmed by a mutation in the MAFB gene.