Journal
MATERIALS TODAY COMMUNICATIONS
Volume 33, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.mtcomm.2022.104560
Keywords
Metal -organic framework; Au nanorods; Magnetic resonance imaging; Photothermal therapy; Cancer
Categories
Funding
- National Nature Science Foundation of People?s Republic of China
- Program for Excellent Talents in University of Ministry of Education of China
- Open Fund of State Key Laboratory of Tea Plant Biology and Utilization
- [81371678]
- [21501003]
- [gxyqZD2020008]
- [SKLTOF20190116]
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Photothermal therapy (PTT) has emerged as a potential anticancer strategy due to its minimal invasion, targeted destruction and low toxicity. In this study, a novel core-shell Au nanorods (Au NRs)@iron-based metal-organic framework (MOF) was successfully fabricated and showed excellent biocompatibility as well as the potential for magnetic resonance imaging (MRI) guided PTT.
Photothermal therapy (PTT) has emerged as a potential anticancer strategy due to its minimal invasion, targeted destruction and low toxicity. It is imperative to fabricate multifunctional photothermal agents with improved performance for effective PTT. In this study, a novel core-shell Au nanorods (Au NRs)@iron-based metal-organic framework (MOF) was successfully fabricated by a layer-by-layer technique. The inner Au NRs have been widely utilized as photothermal materials because of their strong absorption efficiency in NIR region. Owing to the presence of outer MIL-100, the Au NRs@MIL-100 can serve as a T2-weighted magnetic resonance imaging (MRI) contrast agent. The in vitro and in vivo experiments provided evidences that such core-shell Au NRs@MIL-100 with excellent biocompatibility hold great promise for application in MRI guided PTT. Therefore, this work presents a facile and feasible strategy for the development of multifunctional photothermal agents based on MOFs with high efficiency and low side effects.
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