4.6 Article

Layer-by-layer synthesis of Au nanorods@metal-organic framework core-shell nanohybrids for magnetic resonance imaging guided photothermal therapy

Journal

MATERIALS TODAY COMMUNICATIONS
Volume 33, Issue -, Pages -

Publisher

ELSEVIER
DOI: 10.1016/j.mtcomm.2022.104560

Keywords

Metal -organic framework; Au nanorods; Magnetic resonance imaging; Photothermal therapy; Cancer

Funding

  1. National Nature Science Foundation of People?s Republic of China
  2. Program for Excellent Talents in University of Ministry of Education of China
  3. Open Fund of State Key Laboratory of Tea Plant Biology and Utilization
  4. [81371678]
  5. [21501003]
  6. [gxyqZD2020008]
  7. [SKLTOF20190116]

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Photothermal therapy (PTT) has emerged as a potential anticancer strategy due to its minimal invasion, targeted destruction and low toxicity. In this study, a novel core-shell Au nanorods (Au NRs)@iron-based metal-organic framework (MOF) was successfully fabricated and showed excellent biocompatibility as well as the potential for magnetic resonance imaging (MRI) guided PTT.
Photothermal therapy (PTT) has emerged as a potential anticancer strategy due to its minimal invasion, targeted destruction and low toxicity. It is imperative to fabricate multifunctional photothermal agents with improved performance for effective PTT. In this study, a novel core-shell Au nanorods (Au NRs)@iron-based metal-organic framework (MOF) was successfully fabricated by a layer-by-layer technique. The inner Au NRs have been widely utilized as photothermal materials because of their strong absorption efficiency in NIR region. Owing to the presence of outer MIL-100, the Au NRs@MIL-100 can serve as a T2-weighted magnetic resonance imaging (MRI) contrast agent. The in vitro and in vivo experiments provided evidences that such core-shell Au NRs@MIL-100 with excellent biocompatibility hold great promise for application in MRI guided PTT. Therefore, this work presents a facile and feasible strategy for the development of multifunctional photothermal agents based on MOFs with high efficiency and low side effects.

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