3D-printed surgical wound dressing for prolonged 5-fluorouracil delivery from pluronic blending composites

A direct drug delivery system of with the inhibition of multidrug resistance was developed in this study by the polymer mixing of Pluronic block copolymer F127, L121, polyethylene glycol (PEG), and polyvinyl alcohol (PVA). The polymer mixing was defined as Pluronic blending composites (PBCs) and optimized through adjusting the ratio of two different water-soluble homopolymers, PEG and PVA. The chemotherapeutic drugs of 5-fluoro-uracil (5-FU) were released from Pluronic blending composites nearly one month without continuous supple-mentary. Also, the effective ingredient of L121 inhibited multidrug resistance in human pancreatic cancer and caused the malfunction of the ATP binding cassette subfamily C (ABCC) transporter as evidenced by the flow cytometer studies. PBC-3 effectively suppresses the function of ABCC transporter up to 25 days. 5-FU are able to accumulate in the cancer cells of AsPC-1 and PANC-1 at a designated effective concentration. Then, a surgical dressing was prepared by 3D bio-printing technology with Pluronic blending composites cross-linked by sodium alginate. Results show that the surgical dressing of 24 layers with 10 mm x 10 mm would continuously release 5 -FU in effective anticancer concentration for six days.

Automated summary

This study developed a direct drug delivery system by mixing different polymers to create Pluronic blending composites, which effectively inhibited multidrug resistance. The system continuously released chemotherapeutic drugs and anti-cancer ingredients, suppressing transporter function and preparing surgical dressings with 3D bio-printing technology for sustained drug release and anti-cancer effects.