Journal
CELL METABOLISM
Volume 22, Issue 6, Pages 971-982Publisher
CELL PRESS
DOI: 10.1016/j.cmet.2015.10.001
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Funding
- Antidiabetic Food Center - a VINNOVA Centre of Excellence in Research and Innovation at Lund University
- Swedish Research Council
- Torsten foundation
- Ragnar Soderbergs' foundation
- IngaBritt and Arne Lundberg's foundation
- Swedish Foundation for Strategic Research
- Knut and Alice Wallenberg foundation
- Region Vastra Gotaland
- Sahlgrenska University Hospital
- EMBO Long-Term Fellowship ALTF [1305-2014]
- ERC [615362]
- Novo Nordisk Fonden [NNF13OC0008163] Funding Source: researchfish
- European Research Council (ERC) [615362] Funding Source: European Research Council (ERC)
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The gut microbiota plays an important role in human health by interacting with host diet, but there is substantial inter-individual variation in the response to diet. Here we compared the gut microbiota composition of healthy subjects who exhibited improved glucose metabolism following 3-day consumption of barley kernel-based bread (BKB) with those who responded least to this dietary intervention. The Prevotella/Bacteroides ratio was higher in responders than non-responders after BKB. Metagenomic analysis showed that the gut microbiota of responders was enriched in Prevotella copri and had increased potential to ferment complex polysaccharides after BKB. Finally, germ-free mice transplanted with microbiota from responder human donors exhibited improved glucose metabolism and increased abundance of Prevotella and liver glycogen content compared with germ-free mice that received non-responder microbiota. Our findings indicate that Prevotella plays a role in the BKB-induced improvement in glucose metabolism observed in certain individuals, potentially by promoting increased glycogen storage.
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