4.7 Article

Feasibility analysis and study of an intrahepatic portal vein infection hepatic alveolar echinococcosis C57 mouse model

Journal

FRONTIERS IN VETERINARY SCIENCE
Volume 9, Issue -, Pages -

Publisher

FRONTIERS MEDIA SA
DOI: 10.3389/fvets.2022.994652

Keywords

liver; alveolar echinococcosis model; comparison of tissue appearance; histopathology; hepatic alveolar spines ball larva disease

Funding

  1. National Natural Science Foundation of China [8177070684]

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The study successfully established an intrahepatic portal vein infection HAE mouse model and characterized the liver lesions in different groups of mice using imaging and pathological techniques. This provides a theoretical basis for clinical research on HAE.
ObjectiveThe aim of the study was to establish and study an intrahepatic portal vein infection hepatic alveolar echinococcosis (HAE) C57 mouse model and provide a theoretical basis for clinical research on HAE. MethodsC57 mice were used to establish the HAE mouse model. The location, size, morphology, appearance, and pathological changes in liver lesions in different groups of mice were characterized using ultrasound, magnetic resonance imaging (MRI), and haematoxylin and eosin staining. ResultsThe mortality rate of the C57 mice was 20%, and the success rate of infection was 75%. The abdominal ultrasound images and MRIs clearly indicated the location, size, shape, and appearance of the liver lesions and the relationship between the lesions and the adjacent organs. The size, morphology, and signal of the livers in the control group were normal. The pathological results of the experimental group indicated a hepatic vesicular acinar cyst, while those of the control group exhibited normal livers. ConclusionThe intrahepatic portal vein infection HAE mouse model was successfully established.

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