The Development of Systemic Inflammatory Diseases in Hidradenitis Suppurativa

It is understood that the skin is a peripheral lymphoid tissue that defends against external environmental stimuli. Continuous activation from these factors, on the other hand, promotes persistent inflammation at the local location and, occasionally, tissue damage. Hidradenitis suppurativa (HS) is a typical inflammatory skin disease and becomes a source of numerous inflammatory cytokines due to the chronic intractable repeated inflamed tissues. Because inflammatory cells and cytokines circulate throughout the body from the inflamed organ, it has been hypothesized that HS-mediated skin inflammation impacts the systemic functioning of numerous organs. Recent updates to clinical and experimental investigations revealed that HS has a significant connection with systemic inflammatory disorders. We provide the details and comprehensive molecular mechanisms associated with systemic inflammatory illnesses due to HS.

Automated summary

It is known that persistent skin inflammation caused by hidradenitis suppurativa (HS) can impact the functioning of multiple organs due to the circulation of inflammatory cells and cytokines throughout the body. Recent research has revealed a significant connection between HS and systemic inflammatory disorders. This article provides comprehensive molecular mechanisms and details associated with systemic inflammatory illnesses caused by HS.