Phaeochromycins I-K, Three Methylene-Bridged Dimeric Polyketides from Streptomyces sp. 166#

Three new dimeric polyketides, i.e., phaeochromy-cins I-K (1-3, respectively) and a known polyketide phaeochro-mycin F (4), were isolated from the culture broth of a saline Qinghai-Tibet Plateau permafrost soil-derived Streptomyces sp. 166#. The structures were determined by analyzing one-dimen-sional and two-dimensional NMR as well as HRESIMS data. Compounds 2 and 3 exhibited a selective antiproliferative activity against H1299 and HUCCT1 cell lines, exhibiting IC50 values ranging from 8.83 to 10.52 mu M.

Automated summary

Three new dimeric polyketides, phaeochromy-cins I-K (1-3) and a known polyketide phaeochro-mycin F (4), were isolated from the culture broth of a Streptomyces sp. 166# derived from the saline Qinghai-Tibet Plateau permafrost soil. The structures were determined using NMR and HRESIMS data. Compounds 2 and 3 showed selective antiproliferative activity against H1299 and HUCCT1 cell lines, with IC50 values ranging from 8.83 to 10.52 μM.