Journal
CELL METABOLISM
Volume 22, Issue 2, Pages 204-206Publisher
CELL PRESS
DOI: 10.1016/j.cmet.2015.05.013
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Funding
- NCI NIH HHS [R01CA123067] Funding Source: Medline
- NHLBI NIH HHS [5P01HL071643, R01HL12206201] Funding Source: Medline
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Mitochondria have primarily been viewed as bioenergetic and biosynthetic organelles that autonomously co-exist within the cell. However, the past two decades have provided evidence that mitochondria function as signaling organelles, constantly communicating with the cytosol to initiate biological events under homeo-static and stress conditions. Thus, the signaling function of the mitochondria may have been selected by nature from the inception of the early eukaryote, as discussed in this essay.
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